What is the NOAEL for Methyl butyrate?
Methyl butyrate has 8 NOAEL studies in the database. The lowest reported value is CGX598508O UNII. Source: openFDA substances.
NOAEL Data
Cosmetic Ingredient
Methyl butyrate
Also known as: 4-02-00-00786, BRN 1740743, EINECS 210-792-1, FEMA No. 2693, Methyl n-butanoate (+5 more)
CAS 623-42-7
Methyl butyrate (CAS 623-42-7) is a chemical substance. Key regulatory status: 5 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS.
Cross-Vertical Regulatory Divergence
Methyl butyrate is prohibited in EU cosmetics but has active industrial GHS classifications (H225).
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
8
SOURCE
chemical inventory jurisdictions
Regulatory lists
5
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
16 fields
Name
Methyl butyrate
CAS Number
623-42-7
DTXSID
DTXSID5047083
Molecular Formula
C5H10O2
InChI Key
UUIQMZJEGPQKFD-UHFFFAOYSA-N
Monoisotopic Mass
102.06808
Synonyms
4-02-00-00786BRN 1740743EINECS 210-792-1FEMA No. 2693Methyl n-butanoate2-Methyl butyric acidMethyl-n-butyrateUNII-CGX598508OMethyl ester of butanoic acidN-Butyric acid methyl ester
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
6 records
FragranceFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
5 records
| List | Keyword | Source |
|---|---|---|
| air; Cleaning products and household care - air freshener; detected; emissions | Elsevier | CPCat |
| IFRA Transparency | IFRA | IFRA |
| Europe | European Commission | Fl@vis |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| consumer_product | P&G | Proctor & Gamble |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 8 of 8 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| CGX598508O | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| CGX598508O | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| CGX598508O | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| CGX598508O | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 5400 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| >5000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
Showing 8 of 8 studies
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
prohibited
Max
-
Category
Fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL15859
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
ADI: No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Methyl butyrate?
Methyl butyrate appears on 5 regulatory/inventory lists including air; Cleaning products and household care - air freshener; detected; emissions, IFRA Transparency, Europe, and 2 more. Source: EPA CPDat.
Is Methyl butyrate used in cosmetics?
Yes, Methyl butyrate is also indexed as a cosmetic ingredient under the name Methyl Butyrate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Methyl butyrate come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Does Methyl butyrate have different safety status in cosmetics vs industrial chemicals?
Methyl butyrate is prohibited in EU cosmetics but has active industrial GHS classifications (H225).
Is Methyl butyrate used outside industrial chemicals?
Methyl butyrate also appears in cosmetics, pharmaceutical, food safety, cannabis databases.