What is the NOAEL for Cyclohexyl acetate?
Cyclohexyl acetate has 11 NOAEL studies in the database. The lowest reported value is UL0RS4H1UE UNII. Source: openFDA substances.
NOAEL Data
Cosmetic Ingredient
Cyclohexyl acetate
Also known as: Acetic acid, cyclohexyl ester, 4-06-00-00036, Adronal acetate, BRN 1906543, Cyclohexane acetate (+9 more)
CAS 622-45-7
Cyclohexyl acetate (CAS 622-45-7) is a chemical substance. Key regulatory status: 4 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ILO ICSC.
SOURCE
noael studies public
NOAEL studies
11
SOURCE
chemical inventory jurisdictions
Regulatory lists
4
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
20 fields
Name
Cyclohexyl acetate
CAS Number
622-45-7
DTXSID
DTXSID6052299
Molecular Formula
C8H14O2
InChI Key
YYLLIJHXUHJATK-UHFFFAOYSA-N
Monoisotopic Mass
142.09938
Synonyms
Acetic acid, cyclohexyl ester4-06-00-00036Adronal acetateBRN 1906543Cyclohexane acetateCyclohexanol, acetateCyclohexanyl acetateEINECS 210-736-6FEMA No. 2349Hexalin acetateNSC 8772Cyclohexanolazetat
ICSC Chemical Safety
International Chemical Safety Card hazard and exposure summary.
SOURCE
ILO/WHO International Chemical Safety Cards
1 records
| Field | Value |
|---|---|
| GHS Signal Word | WARNING |
| GHS Hazard Statements | Flammable liquid and vapour Causes mild skin irritation Causes eye irritation |
| Short-term Effects | The substance is mildly irritating to the eyes, skin and respiratory tract. The substance may cause effects on the central nervous system. Ingestion of large amounts could cause lowering of consciousness. |
| Long-term Effects | The substance defats the skin, which may cause dryness or cracking. |
| Routes of Exposure | Exposure mainly occurs via inhalation. |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
5 records
FragranceFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
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EPA CPDat
4 records
| List | Keyword | Source |
|---|---|---|
| IFRA Transparency | IFRA | IFRA |
| Europe | European Commission | Fl@vis |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| consumer_product | P&G | Proctor & Gamble |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 11 of 11 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| UL0RS4H1UE | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| UL0RS4H1UE | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| UL0RS4H1UE | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| UL0RS4H1UE | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 2592 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| 2700 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| =6730 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =50 | mg/kg bw/day | NOEL | - | - | INCHEM_WHO_jecfa_jecmono_v50je14 |
| =50 | mg/kg bw/day | NOEL | - | - | INCHEM_WHO_jecfa_jecmono_v50je14 |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
Showing 11 of 11 studies
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Cyclohexyl acetate?
Cyclohexyl acetate appears on 4 regulatory/inventory lists including IFRA Transparency, Europe, food_additive; Substances Added to Food (formerly EAFUS) (2/2019), and 1 more. Source: EPA CPDat.
Is Cyclohexyl acetate used in cosmetics?
Yes, Cyclohexyl acetate is also indexed as a cosmetic ingredient under the name Cyclohexyl Acetate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Cyclohexyl acetate come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ILO/WHO ICSC, CosIng / Ingredients DB, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is Cyclohexyl acetate used outside industrial chemicals?
Cyclohexyl acetate also appears in cosmetics, cannabis databases.