What is the NOAEL for 2-Ethylhexyl-2-cyano-3,3-diphenylacrylate?
2-Ethylhexyl-2-cyano-3,3-diphenylacrylate has 100 NOAEL studies in the database. The lowest reported value is 1 mg/kg bw/day via oral. Source: Regulatory source.
NOAEL Data
REACH Registered
Cosmetic Ingredient
2-Ethylhexyl-2-cyano-3,3-diphenylacrylate
Also known as: 2-Ethylhexyl 2-cyano-3,3-diphenylacrylate, Octocrylene, EINECS 228-250-8, 2-Ethylhexyl 2-cyano-3,3-diphenyl-2-acrylate, Octocrilenum (+1 more)
CAS 6197-30-4
2-Ethylhexyl-2-cyano-3,3-diphenylacrylate (CAS 6197-30-4) is a chemical substance. Key regulatory status: REACH registered, 8 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, SCCS, ECHA REACH.
SOURCE
NOAEL studies
NOAEL studies
100
SOURCE
Chemical inventory jurisdictions
Regulatory lists
8
SOURCE
EU CLP Annex VI
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
12 fields
Name
2-Ethylhexyl-2-cyano-3,3-diphenylacrylate
CAS Number
6197-30-4
DTXSID
DTXSID9025299
Molecular Formula
C24H27NO2
InChI Key
FMJSMJQBSVNSBF-UHFFFAOYSA-N
Monoisotopic Mass
361.204179
Synonyms
2-Ethylhexyl 2-cyano-3,3-diphenylacrylateOctocryleneEINECS 228-250-82-Ethylhexyl 2-cyano-3,3-diphenyl-2-acrylateOctocrilenumUNII-5A68WGF6WM
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
19 records
UV stabilizerFragrance
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
8 records
| List | Keyword | Source |
|---|---|---|
| CEDI | FDA | United States Food and Drug Administration (FDA) |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| IFRA Transparency | IFRA | IFRA |
| Canada; consumer_product; Substances in Products - Canada (4/2014) | Government of Canada | CPCat |
| pharmaceutical | US International Trade Commission | CPCat |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Europe; Personal care | European Commission | CosIng |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 50 of 100 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 1 | - | - | oral | - | Regulatory source |
| 9 | % | - | oral | - | Regulatory source |
| 10 | % | - | oral | - | Regulatory source |
| 12 | - | - | - | - | Regulatory source |
| 13 | - | - | - | - | Regulatory source |
| 14 | - | - | - | - | Regulatory source |
| 38 | - | - | - | - | Regulatory source |
| 39 | - | - | - | - | Regulatory source |
| 76.5 | - | - | - | - | Regulatory source |
| 76.5 | - | - | - | - | Regulatory source |
| 76.5 | - | - | - | - | Regulatory source |
| 76.5 | - | - | - | - | Regulatory source |
| 76.5 | - | - | - | - | Regulatory source |
| 130 | mg/kg/day | - | - | rabbit | Regulatory source |
| 130 | mg/kg/day | - | - | rabbit | Regulatory source |
| 153 | mg/kg bw/day | - | - | rat | Regulatory source |
| 153 | mg/kg bw/day | - | - | human | Regulatory source |
| 153 | mg/kg bw/day | - | - | human | Regulatory source |
| 153 | - | - | oral | - | Regulatory source |
| 1000 | mg/kg bw/day | - | oral | - | Regulatory source |
| 3000 | ppm | - | - | - | Regulatory source |
| =5.4 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB GESTIS DNEL |
| 5A68WGF6WM | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 5A68WGF6WM | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 5A68WGF6WM | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 5A68WGF6WM | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| >5000 | mg/kg bw | LD50 | oral | Rat | NTP ICE acute oral |
| =2100 | ppm | LEL | oral | Rat | ToxValDB EPA TSCA 8e |
| =7000 | ppm | LEL | oral | Rat | ToxValDB EPA TSCA 8e |
| =73923.7 | mg/m3 | LEL | inhalation | Rat | ToxValDB EPA TSCA 8e |
| =221771 | mg/m3 | LEL | inhalation | Rat | ToxValDB EPA TSCA 8e |
| 4500 | ppm | LOAEL | oral | rat | COSMOS DB |
| =1 | - | NOAEL | oral | - | SCCS Opinion |
| =1 | - | NOAEL | oral | - | SCCS Opinion |
| =1 | - | NOAEL | oral | - | SCCS Opinion |
| =1 | - | NOAEL | oral | - | SCCS Opinion |
| =9 | % | NOAEL | oral | - | SCCS Opinion |
| =9 | % | NOAEL | oral | - | SCCS Opinion |
| =9 | % | NOAEL | oral | - | SCCS Opinion |
| =9 | % | NOAEL | oral | - | SCCS Opinion |
| =10 | % | NOAEL | oral | - | SCCS Opinion |
| =10 | % | NOAEL | oral | - | SCCS Opinion |
| =10 | % | NOAEL | oral | - | SCCS Opinion |
| =10 | % | NOAEL | oral | - | SCCS Opinion |
| =12 | - | NOAEL | - | - | SCCS Opinion |
| =12 | - | NOAEL | - | - | SCCS Opinion |
| =12 | - | NOAEL | - | - | SCCS Opinion |
| =12 | - | NOAEL | - | - | SCCS Opinion |
| =13 | - | NOAEL | - | - | SCCS Opinion |
| =13 | - | NOAEL | - | - | SCCS Opinion |
Showing 50 of 100 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Octocrilene | 228-250-8 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
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AICIS inventory
1 records
Inventory Status
listed
SCCS Opinions
EU Scientific Committee opinions tied to the matched substance.
SOURCE
SCCS Opinion
1 opinions
| Opinion | Date | Conclusion | Max Conc. | Concerns |
|---|---|---|---|---|
| SCCS/1627/21 | 30-31 March 2021 | safe with restrictions | up to 10% (individual use); propellant spray max 9% in combined use scenarios | Potential endocrine disrupting properties (indications only; not conclusive); photo-instability/potential to form benzophenone; persistent bioaccumulative and toxic in aquatic environment |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
10%
Category
active
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
ChEMBL / DailyMed
OCTOCRYLENE
ChEMBL Phase
4
Adverse Events
95
Bioactivity
3
Frequently Asked Questions
What regulatory lists include 2-Ethylhexyl-2-cyano-3,3-diphenylacrylate?
2-Ethylhexyl-2-cyano-3,3-diphenylacrylate appears on 7 regulatory/inventory lists including CEDI, inert_ingredient; non_food_use; Pesticides, IFRA Transparency, and 4 more. Source: EPA CPDat.
Is 2-Ethylhexyl-2-cyano-3,3-diphenylacrylate used in cosmetics?
Yes, 2-Ethylhexyl-2-cyano-3,3-diphenylacrylate is also indexed as a cosmetic ingredient under the name Octocrylene. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 2-Ethylhexyl-2-cyano-3,3-diphenylacrylate come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Is 2-Ethylhexyl-2-cyano-3,3-diphenylacrylate used outside industrial chemicals?
2-Ethylhexyl-2-cyano-3,3-diphenylacrylate also appears in cosmetics, pharmaceutical databases.