What is the NOAEL for 2-Furancarboxylic acid, methyl ester?
2-Furancarboxylic acid, methyl ester has 14 NOAEL studies in the database. The lowest reported value is O9A8D29YDE UNII. Source: openFDA substances.
NOAEL Data
Cosmetic Ingredient
2-Furancarboxylic acid, methyl ester
Also known as: 5-18-06-00103, BRN 0111110, EINECS 210-254-6, FEMA No. 2703, 2-(Methoxycarbonyl)furan (+6 more)
CAS 611-13-2
2-Furancarboxylic acid, methyl ester (CAS 611-13-2) is a chemical substance. Key regulatory status: 4 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS.
Cross-Vertical Regulatory Divergence
2-Furancarboxylic acid, methyl ester is classified GHS Danger (H301) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
NOAEL studies
NOAEL studies
14
SOURCE
Chemical inventory jurisdictions
Regulatory lists
4
SOURCE
EU CLP Annex VI
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
17 fields
Name
2-Furancarboxylic acid, methyl ester
CAS Number
611-13-2
DTXSID
DTXSID7060598
Molecular Formula
C6H6O3
InChI Key
HDJLSECJEQSPKW-UHFFFAOYSA-N
Monoisotopic Mass
126.031694
Synonyms
5-18-06-00103BRN 0111110EINECS 210-254-6FEMA No. 27032-(Methoxycarbonyl)furanMethyl 2-furancarboxylateMethyl 2-furylcarboxylateMethyl pyromucateNSC 35551Pyromucic acid methyl esterUNII-O9A8D29YDE
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
6 records
FragranceFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
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EPA CPDat
4 records
| List | Keyword | Source |
|---|---|---|
| IFRA Transparency | IFRA | IFRA |
| Europe | European Commission | Fl@vis |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| consumer_product | P&G | Proctor & Gamble |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 14 of 14 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| O9A8D29YDE | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| O9A8D29YDE | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| O9A8D29YDE | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| O9A8D29YDE | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | % | Incidence of positive responses | Dermal | Human | NTP ICE skin sensitization |
| 6750 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP ICE skin sensitization |
| =300 | mg/kg bw | LD50 | oral | Rat | NTP ICE acute oral |
| =54 | mg/kg bw/day | NOAEL | oral | Rat | EFSA |
| =54 | mg/kg bw/day | NOAEL | oral: feed | Rat | EFSA |
| =54 | mg/kg bw/day | NOAEL | oral: feed | Rat | EFSA |
| =53 | mg/kg bw/day | NOEL | oral | Rat | EFSA |
| =53 | mg/kg bw/day | NOEL | oral: feed | Rat | EFSA |
| =53 | mg/kg bw/day | NOEL | oral: feed | Rat | EFSA |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP ICE skin sensitization |
Showing 14 of 14 studies
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
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AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include 2-Furancarboxylic acid, methyl ester?
2-Furancarboxylic acid, methyl ester appears on 4 regulatory/inventory lists including IFRA Transparency, Europe, food_additive; Substances Added to Food (formerly EAFUS) (2/2019), and 1 more. Source: EPA CPDat.
Is 2-Furancarboxylic acid, methyl ester used in cosmetics?
Yes, 2-Furancarboxylic acid, methyl ester is also indexed as a cosmetic ingredient under the name Methyl Furoate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 2-Furancarboxylic acid, methyl ester come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, CosIng / Ingredients DB, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Does 2-Furancarboxylic acid, methyl ester have different safety status in cosmetics vs industrial chemicals?
2-Furancarboxylic acid, methyl ester is classified GHS Danger (H301) in the chemicals database but is allowed in EU cosmetics.
Is 2-Furancarboxylic acid, methyl ester used outside industrial chemicals?
2-Furancarboxylic acid, methyl ester also appears in cosmetics, cannabis databases.