NOAEL Data REACH Registered Cosmetic Ingredient

4-Amino-3-nitrophenol

Also known as: 3-Nitro-4-aminophenol, Phenol, 4-amino-3-nitro-, EINECS 210-236-8, NSC 400380, UNII-R5WY41Q95Z

CAS 610-81-1

4-Amino-3-nitrophenol (CAS 610-81-1) is a chemical substance. Key regulatory status: REACH registered, 16 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, SCCS, ECHA REACH.

View cosmetic safety profile for 4-Amino-3-Nitrophenol →

SOURCE noael studies public

NOAEL studies

SOURCE chemical inventory jurisdictions

Regulatory lists

SOURCE eu clp annex vi

GHS signal

Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 11 fields

Name

4-Amino-3-nitrophenol

CAS Number

610-81-1

DTXSID

DTXSID50209864

Molecular Formula

C6H6N2O3

InChI Key

IQXUIDYRTHQTET-UHFFFAOYSA-N

Monoisotopic Mass

154.037842

Synonyms

3-Nitro-4-aminophenolPhenol, 4-amino-3-nitro-EINECS 210-236-8NSC 400380UNII-R5WY41Q95Z

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 4 records

Dye

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 16 records

List	Keyword	Source
Europe; Personal care; restricted	European Commission	CosIng
Europe; Personal care - hair coloring	Danish Environmental Protection Agency	Danish EPA
children; Europe; Personal care	Danish Environmental Protection Agency	Danish EPA
children; Europe; Personal care	Danish Environmental Protection Agency	Danish EPA
children; Europe; Personal care	Danish Environmental Protection Agency	Danish EPA
Europe; Personal care - hair coloring	Danish Environmental Protection Agency	Danish EPA
Europe; Personal care - hair coloring	Danish Environmental Protection Agency	Danish EPA
detected; Europe; Personal care - hair coloring - hair color - professional	Danish Environmental Protection Agency	Danish EPA
detected; Europe; Personal care - hair coloring	Danish Environmental Protection Agency	Danish EPA
detected; Europe; Personal care - hair coloring - hair color - professional	Danish Environmental Protection Agency	Danish EPA
detected; Europe; Personal care - hair coloring	Danish Environmental Protection Agency	Danish EPA
detected; Europe; Personal care - hair coloring - hair color - professional	Danish Environmental Protection Agency	Danish EPA
detected; Europe; Personal care - hair coloring	Danish Environmental Protection Agency	Danish EPA
detected; Europe; Personal care - hair coloring	Danish Environmental Protection Agency	Danish EPA
detected; Europe; Personal care - hair coloring	Danish Environmental Protection Agency	Danish EPA
-	Danish Environmental Protection Agency	Danish EPA

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 50 of 62 studies

Value	Unit	Endpoint	Route	Species	Source
50	mg/kg bw	-	-	-	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
100	mg/kg bw	-	-	-	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
100	mg/kg bw	-	oral	rat	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
250	mg/kg bw	-	-	-	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
0.2	%	EC3	Dermal	Mouse	NTP_ICE_skin_sensitization
R5WY41Q95Z	UNII	FDA UNII substance identifier	-	-	openFDA substances
R5WY41Q95Z	UNII	FDA UNII substance identifier	-	-	openFDA substances
R5WY41Q95Z	UNII	FDA UNII substance identifier	-	-	openFDA substances
R5WY41Q95Z	UNII	FDA UNII substance identifier	-	-	openFDA substances
10	mg/kg bw/day	LOAEL	oral	rat	COSMOS_DB
=0.01	mg/kg	NOAEL	oral	rat	SCCS_vision_codex
=0.01	mg/kg	NOAEL	oral	rat	SCCS_vision_codex
=0.01	mg/kg	NOAEL	oral	rat	SCCS_vision_codex
=0.01	mg/kg	NOAEL	oral	rat	SCCS_vision_codex
=0.061	mg/kg	NOAEL	oral	rat	SCCS_vision_codex
=0.061	mg/kg	NOAEL	oral	rat	SCCS_vision_codex
=0.061	mg/kg	NOAEL	oral	rat	SCCS_vision_codex
=0.061	mg/kg	NOAEL	oral	rat	SCCS_vision_codex
=20	mg/kg bw	NOAEL	-	-	SCCS_vision_codex
=20	mg/kg bw	NOAEL	-	-	SCCS_vision_codex
=20	mg/kg bw	NOAEL	-	-	SCCS_vision_codex
=20	mg/kg bw	NOAEL	-	-	SCCS_vision_codex
=50	mg/kg bw	NOAEL	-	-	SCCS_vision_codex
=50	mg/kg bw	NOAEL	-	-	SCCS_vision_codex
=50	mg/kg bw	NOAEL	-	-	SCCS_vision_codex
=50	mg/kg bw	NOAEL	-	-	SCCS_vision_codex
=60	mg/kg bw	NOAEL	oral	rat	SCCS_vision_codex
=60	mg/kg bw	NOAEL	oral	rat	SCCS_vision_codex
=60	mg/kg bw	NOAEL	oral	rat	SCCS_vision_codex
=60	mg/kg bw	NOAEL	oral	rat	SCCS_vision_codex
=100	mg/kg bw	NOAEL	-	-	SCCS_vision_codex
=100	mg/kg bw	NOAEL	-	-	SCCS_vision_codex
=100	mg/kg bw	NOAEL	-	-	SCCS_vision_codex
=100	mg/kg bw	NOAEL	-	-	SCCS_vision_codex
=250	mg/kg bw	NOAEL	oral	-	SCCS_vision_codex
=250	mg/kg bw	NOAEL	oral	-	SCCS_vision_codex
=250	mg/kg bw	NOAEL	oral	-	SCCS_vision_codex
=250	mg/kg bw	NOAEL	oral	-	SCCS_vision_codex
=400	mg/kg/day	NOAEL	oral	-	SCCS_vision_codex
=400	mg/kg/day	NOAEL	oral	-	SCCS_vision_codex
=400	mg/kg/day	NOAEL	oral	-	SCCS_vision_codex
=400	mg/kg/day	NOAEL	oral	-	SCCS_vision_codex
=0.01	mg/kg	dermal absorption	oral	rat	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
=0.061	mg/kg	dermal absorption	oral	rat	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
=60	mg/kg bw	dermal absorption	oral	rat	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
=60	mg/kg bw	dermal absorption	oral	rat	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
=60	mg/kg bw	dermal absorption	oral	rat	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
=60	mg/kg bw	dermal absorption	oral	rat	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
20	mg/kg bw	developmental toxicity	-	-	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
20	mg/kg bw	developmental toxicity	-	-	UnifiedCodex:SCCS_SHADOW:beta.noael_studies

Showing 50 of 62 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records

Status	Name	EC Number	Link
Registered	4-amino-3-nitrophenol	210-236-8	ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

SCCS Opinions

EU Scientific Committee opinions tied to the matched substance.

SOURCE EU SCCS 2 opinions

Opinion	Date	Conclusion	Max Conc.	Concerns
SCCP/1181/08	16 December 2008	safe	1.0%	sensitisation potential not excluded
SCCP/1061/07	21 March 2007	safe	1.0%	sensitisation not excluded; secondary amine

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

permitted

Max

Frequently Asked Questions

What is the NOAEL for 4-Amino-3-nitrophenol?

4-Amino-3-nitrophenol has 62 NOAEL studies in the database. The lowest reported value is 0.01 mg/kg via oral in rat. Source: SCCS_vision_codex.

What regulatory lists include 4-Amino-3-nitrophenol?

4-Amino-3-nitrophenol appears on 5 regulatory/inventory lists including Europe; Personal care; restricted, Europe; Personal care - hair coloring, children; Europe; Personal care, and 2 more. Source: EPA CPDat.

Is 4-Amino-3-nitrophenol used in cosmetics?

Yes, 4-Amino-3-nitrophenol is also indexed as a cosmetic ingredient under the name 4-Amino-3-Nitrophenol. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 4-Amino-3-nitrophenol come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.

Is 4-Amino-3-nitrophenol used outside industrial chemicals?

4-Amino-3-nitrophenol also appears in cosmetics databases.