What is the NOAEL for 2-Methyl-1,3-benzenediol?
2-Methyl-1,3-benzenediol has 73 NOAEL studies in the database. The lowest reported value is 0.024 mg/kg via dermal in human. Source: UnifiedCodex:SCCS_SHADOW:beta.noael_studies.
NOAEL Data
REACH Registered
Cosmetic Ingredient
2-Methyl-1,3-benzenediol
Also known as: 4-06-00-05877, BRN 2042177, EINECS 210-155-8, UNII-32W7044A3T
CAS 608-25-3
2-Methyl-1,3-benzenediol (CAS 608-25-3) is a chemical substance. Key regulatory status: REACH registered, 16 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, SCCS, ECHA REACH.
View cosmetic safety profile for 2-Methylresorcinol ⭐ (Most extensively assessed) →
Cross-Vertical Regulatory Divergence
2-Methyl-1,3-benzenediol is prohibited in EU cosmetics at max 1.8% but has active industrial GHS classifications (H301, H315, H317, H318, H319, H335, H400, H410).
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status/eu_max; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
73
SOURCE
chemical inventory jurisdictions
Regulatory lists
16
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
10 fields
Name
2-Methyl-1,3-benzenediol
CAS Number
608-25-3
DTXSID
DTXSID0025571
Molecular Formula
C7H8O2
InChI Key
ZTMADXFOCUXMJE-UHFFFAOYSA-N
Monoisotopic Mass
124.052429
Synonyms
4-06-00-05877BRN 2042177EINECS 210-155-8UNII-32W7044A3T
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
4 records
Dye
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
16 records
| List | Keyword | Source |
|---|---|---|
| Europe; Personal care; restricted | European Commission | CosIng |
| Europe; Personal care - hair coloring | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Personal care - hair coloring - hair color - permanent | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Personal care - hair coloring - hair color - permanent | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Personal care - hair coloring - hair color - professional | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Personal care - hair coloring - hair color - professional | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Personal care - hair coloring | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Personal care - hair coloring - hair color - professional | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Personal care - hair coloring | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Personal care - hair coloring | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Personal care - hair coloring | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Personal care - hair coloring | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Personal care - hair coloring - hair color - professional | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Personal care - hair coloring | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Personal care - hair coloring | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Personal care - hair coloring | Danish Environmental Protection Agency | Danish EPA |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 50 of 73 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 100 | mg/kg bw | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 100 | mg/kg bw | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| =4.93 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 32W7044A3T | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 32W7044A3T | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 32W7044A3T | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 32W7044A3T | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =200 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| 100 | mg/kg bw/day | LOAEL | oral | rat | COSMOS_DB |
| =0.024 | mg/kg | NOAEL | dermal | human | SCCS_vision_codex |
| =0.024 | mg/kg bw | NOAEL | dermal | human | SCCS_vision_codex |
| =0.024 | mg/kg | NOAEL | dermal | human | SCCS_vision_codex |
| =0.024 | mg/kg | NOAEL | dermal | human | SCCS_vision_codex |
| =0.024 | mg/kg bw | NOAEL | dermal | human | SCCS_vision_codex |
| =0.024 | mg/kg bw | NOAEL | dermal | human | SCCS_vision_codex |
| =0.024 | mg/kg | NOAEL | dermal | human | SCCS_vision_codex |
| =0.024 | mg/kg bw | NOAEL | dermal | human | SCCS_vision_codex |
| =0.14 | mg/kg bw | NOAEL | dermal | human | SCCS_vision_codex |
| =0.14 | mg/kg bw | NOAEL | dermal | human | SCCS_vision_codex |
| =0.14 | mg/kg bw | NOAEL | dermal | human | SCCS_vision_codex |
| =0.14 | mg/kg bw | NOAEL | dermal | human | SCCS_vision_codex |
| =100 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =100 | mg/kg bw | NOAEL | - | - | SCCS_vision_codex |
| =100 | mg/kg | NOAEL | dermal | human | SCCS_vision_codex |
| =100 | mg/kg bw | NOAEL | - | - | SCCS_vision_codex |
| =100 | mg/kg bw | NOAEL | - | - | SCCS_vision_codex |
| =100 | mg/kg | NOAEL | dermal | human | SCCS_vision_codex |
| =100 | mg/kg bw | NOAEL | - | - | SCCS_vision_codex |
| =100 | mg/kg | NOAEL | dermal | human | SCCS_vision_codex |
| =100 | mg/kg bw | NOAEL | - | - | SCCS_vision_codex |
| =100 | mg/kg bw | NOAEL | - | - | SCCS_vision_codex |
| =100 | mg/kg bw | NOAEL | - | - | SCCS_vision_codex |
| =100 | mg/kg | NOAEL | dermal | human | SCCS_vision_codex |
| =100 | mg/kg bw | NOAEL | - | - | SCCS_vision_codex |
| =400 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =400 | mg/kg bw/day | NOAEL | - | - | SCCS_vision_codex |
| =400 | mg/kg bw/day | NOAEL | - | - | SCCS_vision_codex |
| =400 | mg/kg bw/day | NOAEL | - | - | SCCS_vision_codex |
| =400 | mg/kg bw/day | NOAEL | - | - | SCCS_vision_codex |
| =400 | mg/kg bw/day | NOAEL | - | - | SCCS_vision_codex |
| =400 | mg/kg bw/day | NOAEL | - | - | SCCS_vision_codex |
| =400 | mg/kg bw/day | NOAEL | - | - | SCCS_vision_codex |
| =400 | mg/kg bw/day | NOAEL | - | - | SCCS_vision_codex |
| =900 | mg/kg bw | NOAEL | oral | rat | SCCS_vision_codex |
| =900 | mg/kg bw | NOAEL | oral | rat | SCCS_vision_codex |
| =900 | mg/kg bw | NOAEL | oral | rat | SCCS_vision_codex |
| =900 | mg/kg bw | NOAEL | oral | rat | SCCS_vision_codex |
| =900 | mg/kg bw | NOAEL | oral | rat | SCCS_vision_codex |
| =900 | mg/kg bw | NOAEL | oral | rat | SCCS_vision_codex |
| =900 | mg/kg bw | NOAEL | oral | rat | SCCS_vision_codex |
Showing 50 of 73 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 2-methylresorcinol | 210-155-8 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
SCCS Opinions
EU Scientific Committee opinions tied to the matched substance.
SOURCE
EU SCCS
2 opinions
| Opinion | Date | Conclusion | Max Conc. | Concerns |
|---|---|---|---|---|
| SCCP/1186/08 | 16 December 2008 | safe | 1.8% | sensitisation potential; moderate |
| SCCP/0978/06 | 10 October 2006 | safe | 1.8% | sensitisation potential not excluded |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
prohibited
Max
1.8%
Category
Colorant
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL2332773
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Frequently Asked Questions
What regulatory lists include 2-Methyl-1,3-benzenediol?
2-Methyl-1,3-benzenediol appears on 5 regulatory/inventory lists including Europe; Personal care; restricted, Europe; Personal care - hair coloring, detected; Europe; Personal care - hair coloring - hair color - permanent, and 2 more. Source: EPA CPDat.
Is 2-Methyl-1,3-benzenediol used in cosmetics?
Yes, 2-Methyl-1,3-benzenediol is also indexed as a cosmetic ingredient under the name 2-Methylresorcinol ⭐ (Most extensively assessed). View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 2-Methyl-1,3-benzenediol come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Does 2-Methyl-1,3-benzenediol have different safety status in cosmetics vs industrial chemicals?
2-Methyl-1,3-benzenediol is prohibited in EU cosmetics at max 1.8% but has active industrial GHS classifications (H301, H315, H317, H318, H319, H335, H400, H410).
Is 2-Methyl-1,3-benzenediol used outside industrial chemicals?
2-Methyl-1,3-benzenediol also appears in cosmetics, pharmaceutical databases.