What is the NOAEL for Salicylic acid p-tolyl ester?
Salicylic acid p-tolyl ester has 8 NOAEL studies in the database. The lowest reported value is 8S7I019XJF UNII. Source: openFDA substances.
NOAEL Data
Cosmetic Ingredient
Salicylic acid p-tolyl ester
Also known as: 4-Methylphenyl salicylate, Benzoic acid, 2-hydroxy-, 4-methylphenyl ester, 3-10-00-00132, BRN 2114441, p-Cresyl salicylate (+3 more)
CAS 607-88-5
Salicylic acid p-tolyl ester (CAS 607-88-5) is a chemical substance. Key regulatory status: 2 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS.
View cosmetic safety profile for Hydroxypropyl Methylcellulose →
SOURCE
noael studies public
NOAEL studies
8
SOURCE
chemical inventory jurisdictions
Regulatory lists
2
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
14 fields
Name
Salicylic acid p-tolyl ester
CAS Number
607-88-5
DTXSID
DTXSID3047508
Molecular Formula
C14H12O3
InChI Key
AMYKXJAXRJCLCV-UHFFFAOYSA-N
Monoisotopic Mass
228.078644
Synonyms
4-Methylphenyl salicylateBenzoic acid, 2-hydroxy-, 4-methylphenyl ester3-10-00-00132BRN 2114441p-Cresyl salicylateEINECS 210-144-84-Methylphenyl 2-hydroxybenzoateNSC 60999
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
3 records
Fragrance
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
2 records
| List | Keyword | Source |
|---|---|---|
| IFRA Transparency | IFRA | IFRA |
| consumer_product | P&G | Proctor & Gamble |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 8 of 8 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 8S7I019XJF | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 8S7I019XJF | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 8S7I019XJF | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 8S7I019XJF | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 2700 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| =1300 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
Showing 8 of 8 studies
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
rheology-modifier
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL2260698
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Frequently Asked Questions
What regulatory lists include Salicylic acid p-tolyl ester?
Salicylic acid p-tolyl ester appears on 2 regulatory/inventory lists including IFRA Transparency, consumer_product. Source: EPA CPDat.
Is Salicylic acid p-tolyl ester used in cosmetics?
Yes, Salicylic acid p-tolyl ester is also indexed as a cosmetic ingredient under the name Hydroxypropyl Methylcellulose. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Salicylic acid p-tolyl ester come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Is Salicylic acid p-tolyl ester used outside industrial chemicals?
Salicylic acid p-tolyl ester also appears in cosmetics, pharmaceutical databases.