What is the NOAEL for Triphenylphosphine?
Triphenylphosphine has 14 NOAEL studies in the database. The lowest reported value is 0.5 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Triphenylphosphine
Also known as: Triphenyl phosphine, 4-16-00-00951, BRN 0610776, EINECS 210-036-0, Trifenylfosfin (+1 more)
CAS 603-35-0
Triphenylphosphine (CAS 603-35-0) is a chemical substance. Key regulatory status: REACH registered, 1 regulatory/inventory list, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC.
Cross-Vertical Regulatory Divergence
Triphenylphosphine is classified GHS Danger (H302, H317, H318, H372, H373, H413, H315, H319) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
14
SOURCE
chemical inventory jurisdictions
Regulatory lists
1
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
12 fields
Name
Triphenylphosphine
CAS Number
603-35-0
DTXSID
DTXSID5026251
Molecular Formula
C18H15P
InChI Key
RIOQSEWOXXDEQQ-UHFFFAOYSA-N
Monoisotopic Mass
262.091137
Synonyms
Triphenyl phosphine4-16-00-00951BRN 0610776EINECS 210-036-0TrifenylfosfinUNII-26D26OA393
ICSC Chemical Safety
International Chemical Safety Card hazard and exposure summary.
SOURCE
ILO/WHO International Chemical Safety Cards
1 records
| Field | Value |
|---|---|
| GHS Signal Word | WARNING |
| GHS Hazard Statements | Harmful if swallowed May cause an allergic skin reaction May cause damage to nervous system through prolonged or repeated exposure |
| Short-term Effects | The substance is mildly irritating to the eyes, skin and respiratory tract. |
| Long-term Effects | Repeated or prolonged contact may cause skin sensitization. The substance may have effects on the nervous system. This may result in impaired functions. |
| Routes of Exposure | The substance can be absorbed into the body by inhalation of its aerosol and by ingestion. |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
6 records
Softener and conditionerHeat stabilizerCatalystUV stabilizerHardener
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
1 records
| List | Keyword | Source |
|---|---|---|
| Europe | European Chemicals Agency | European Chemicals Agency (ECHA) |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 14 of 14 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 29.8242103794311 | uM | AC50 | - | - | NTP_ICE_endocrine |
| 18.792225661423 | uM | ACC | - | - | NTP_ICE_endocrine |
| =0.5 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 26D26OA393 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 26D26OA393 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 26D26OA393 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 26D26OA393 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 12.1684 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| =700 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
| 0.00198 | unitless | Model Score | - | - | NTP_ICE_endocrine |
| 0.0652 | unitless | Model Score | - | - | NTP_ICE_endocrine |
| =60 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_HESS |
| =6 | mg/kg bw/day | NOEL | oral | Rat | ToxValDB_HESS |
Showing 14 of 14 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Triphenylphosphine | 210-036-0 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Cosmetic Ingredient
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL1448331
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
1
Frequently Asked Questions
What regulatory lists include Triphenylphosphine?
Triphenylphosphine appears on 1 regulatory/inventory list including Europe. Source: EPA CPDat.
Is Triphenylphosphine used in cosmetics?
Yes, Triphenylphosphine is also indexed as a cosmetic ingredient under the name Triphenylphosphine. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Triphenylphosphine come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Does Triphenylphosphine have different safety status in cosmetics vs industrial chemicals?
Triphenylphosphine is classified GHS Danger (H302, H317, H318, H372, H373, H413, H315, H319) in the chemicals database but is allowed in EU cosmetics.
Is Triphenylphosphine used outside industrial chemicals?
Triphenylphosphine also appears in cosmetics, pharmaceutical databases.