Warning GHS08GHS09 NOAEL Data Cosmetic Ingredient

Fenarimol

Also known as: alpha-(2-Chlorophenyl)-alpha-(4-chlorophenyl)-5-pyrimidinemethanol, 5-Pyrimidinemethanol, alpha-(2-chlorophenyl)-alpha-(4-chlorophenyl)-, 5-Pyrimidinemethanol, .alpha.-(2-chlorophenyl)-.alpha.-(4-chlorophenyl)-, BRN 5972869, Caswell No. 207AA (+7 more)

CAS 60168-88-9

Fenarimol (CAS 60168-88-9) is a chemical substance with GHS signal word Warning; key hazard signal: H361fd; H362; H411. Key regulatory status: 60 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, EPA TRI.

View cosmetic safety profile for Quaternium-71 →

Cross-Vertical Regulatory Divergence

Fenarimol is classified GHS CMR hazard (H361fd, H362, H411) in the chemicals database but is allowed in EU cosmetics.

SOURCE Cross-vertical comparison Cosmetics: ingredients.eu_status; Chemicals: eu_clp_annex_vi.signal_word/hazard_statement_code

SOURCE noael studies public

NOAEL studies

100

SOURCE chemical inventory jurisdictions

Regulatory lists

SOURCE eu clp annex vi

GHS signal

Warning

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 18 fields

Name

Fenarimol

CAS Number

60168-88-9

DTXSID

DTXSID2032390

Molecular Formula

C17H12Cl2N2O

InChI Key

NHOWDZOIZKMVAI-UHFFFAOYSA-N

Monoisotopic Mass

330.032668

Synonyms

alpha-(2-Chlorophenyl)-alpha-(4-chlorophenyl)-5-pyrimidinemethanol5-Pyrimidinemethanol, alpha-(2-chlorophenyl)-alpha-(4-chlorophenyl)-5-Pyrimidinemethanol, .alpha.-(2-chlorophenyl)-.alpha.-(4-chlorophenyl)-BRN 5972869Caswell No. 207AACompound 56722(+-)-2,4'-Dichloro-alpha-(pyrimidin-5-yl)benzhydryl alcoholEINECS 262-095-7EPA Pesticide Chemical Code 206600RimidinUNII-O088GU930QEL 222

GHS / CLP Classification

EU harmonized hazard classification, hazard statements, pictograms, and signal word.

SOURCE EU CLP Annex VI (ECHA) 1 classifications

Hazard Class	H-Statements	Pictograms	Signal
Repr. 2; Lact.; Aquatic Chronic 2	H361fd; H362; H411	GHS08; GHS09	Warning

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 13 records

Biocide

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 60 records

List	Keyword	Source
active_ingredient; agricultural; Pesticides	Arizona Department of Environmental Quality	State of Arizona
active_ingredient; agricultural; Pesticides	Arizona Department of Environmental Quality	State of Arizona
active_ingredient; agricultural; Pesticides	Arizona Department of Environmental Quality	State of Arizona
active_ingredient; agricultural; Pesticides	Arizona Department of Environmental Quality	State of Arizona
active_ingredient; agricultural; Pesticides	Arizona Department of Environmental Quality	State of Arizona
active_ingredient; agricultural; Pesticides	Arizona Department of Environmental Quality	State of Arizona
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Europe; Pesticides	European Commission	CPCat
active_ingredient; Australia	Australian Pesticides and Veterinary Medicines Authority	CPCat
detected; general_crops; Pesticides; residue	FDA	United States Food and Drug Administration (FDA)
detected; general_crops; Pesticides; residue	FDA	United States Food and Drug Administration (FDA)
animal_feed; detected; Pesticides; residue	FDA	United States Food and Drug Administration (FDA)
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; agricultural; applied; fruits_and_vegetables; Pesticides	USDA	United States Department of Agriculture (USDA)
active_ingredient; agricultural; applied; fruits_and_vegetables; Pesticides	USDA	United States Department of Agriculture (USDA)
active_ingredient; agricultural; applied; fruits_and_vegetables; Pesticides	USDA	United States Department of Agriculture (USDA)
active_ingredient; agricultural; applied; fruits_and_vegetables; Pesticides	USDA	United States Department of Agriculture (USDA)
active_ingredient; agricultural; applied; fruits_and_vegetables; Pesticides	USDA	United States Department of Agriculture (USDA)
active_ingredient; agricultural; applied; fruits_and_vegetables; Pesticides	USDA	United States Department of Agriculture (USDA)
active_ingredient; agricultural; applied; fruits_and_vegetables; Pesticides	USDA	United States Department of Agriculture (USDA)

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 50 of 100 studies

Value	Unit	Endpoint	Route	Species	Source
12.8966546219347	uM	AC50	-	-	NTP_ICE_endocrine
36.47393433	uM	AC50	-	-	NTP_ICE_endocrine
23300	nM	AC50/EC50/IC50	-	-	NTP_ICE_endocrine
25000	nM	AC50/EC50/IC50	-	-	NTP_ICE_endocrine
47200	nM	AC50/EC50/IC50	-	-	NTP_ICE_endocrine
71500	nM	AC50/EC50/IC50	-	-	NTP_ICE_endocrine
9.98721302600318	uM	ACC	-	-	NTP_ICE_endocrine
40.8615293743551	uM	ACC	-	-	NTP_ICE_endocrine
=0.02	mg/kg bw/day	ARfD	-	Consumers	EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx
=0.02	mg/kg bw/day	ARfD	-	Consumers	EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx
1.57	uL/min/10^6 cells	Clint	-	Rat	NTP_ICE_adme_parameters
3.788	uL/min/10^6 cells	Clint	-	Human	NTP_ICE_adme_parameters
O088GU930Q	UNII	FDA UNII substance identifier	-	-	openFDA substances
O088GU930Q	UNII	FDA UNII substance identifier	-	-	openFDA substances
O088GU930Q	UNII	FDA UNII substance identifier	-	-	openFDA substances
O088GU930Q	UNII	FDA UNII substance identifier	-	-	openFDA substances
0.0276	fraction	Fu	-	Rat	NTP_ICE_adme_parameters
0.03671	fraction	Fu	-	Human	NTP_ICE_adme_parameters
7000	nM	IC20	-	-	NTP_ICE_endocrine
<10000	nM	IC25	-	-	NTP_ICE_endocrine
=2500	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
=1.2	mg/kg bw/day	LEL	oral	Rat	ToxValDB_ToxRefDB
=1.2	mg/kg bw/day	LEL	oral	rat (wistar; Wistar)	ToxRefDB_ToxRefDB_v3_pod.csv
=2.7	mg/kg bw/day	LEL	oral	Rat	ToxValDB_ToxRefDB
=2.7	mg/kg bw/day	LEL	oral	rat (wistar; Wistar)	ToxRefDB_ToxRefDB_v3_pod.csv
>3.2	mg/kg bw/day	LEL	oral	Rat	ToxValDB_ToxRefDB
>3.2	mg/kg bw/day	LEL	oral	rat (wistar; Wistar)	ToxRefDB_ToxRefDB_v3_pod.csv
=3.5	mg/kg bw/day	LEL	oral	Rat	ToxValDB_ToxRefDB
=3.5	mg/kg bw/day	LEL	oral	rat (wistar; Wistar)	ToxRefDB_ToxRefDB_v3_pod.csv
=3.8	mg/kg bw/day	LEL	oral	Rat	ToxValDB_ToxRefDB
=3.8	mg/kg bw/day	LEL	oral	rat (wistar; Wistar)	ToxRefDB_ToxRefDB_v3_pod.csv
=7.6	mg/kg bw/day	LEL	oral	Rat	ToxValDB_ToxRefDB
=7.6	mg/kg bw/day	LEL	oral	rat (wistar; Wistar)	ToxRefDB_ToxRefDB_v3_pod.csv
=14.6	mg/kg bw/day	LEL	oral	Rat	ToxValDB_ToxRefDB
=14.6	mg/kg bw/day	LEL	oral	rat (wistar; Wistar)	ToxRefDB_ToxRefDB_v3_pod.csv
=17.5	mg/kg bw/day	LEL	oral	Rat	ToxValDB_ToxRefDB
=17.5	mg/kg bw/day	LEL	oral	rat (wistar; Wistar)	ToxRefDB_ToxRefDB_v3_pod.csv
=35	mg/kg bw/day	LEL	oral	Rat	ToxValDB_ToxRefDB
=35	mg/kg bw/day	LEL	oral	rat (wistar; Wistar)	ToxRefDB_ToxRefDB_v3_pod.csv
=86	mg/kg bw/day	LEL	oral	Mouse	ToxValDB_ToxRefDB
=86	mg/kg bw/day	LEL	oral	mouse	ToxRefDB_ToxRefDB_v3_pod.csv
=125	mg/kg bw/day	LEL	oral	Dog	ToxValDB_ToxRefDB
=125	mg/kg bw/day	LEL	oral	dog (beagle; beagle)	ToxRefDB_ToxRefDB_v3_pod.csv
=150	mg/kg bw/day	LEL	oral	Rabbit	ToxValDB_ToxRefDB
=150	mg/kg bw/day	LEL	oral	rabbit (new zealand white; New Zealand White)	ToxRefDB_ToxRefDB_v3_pod.csv
=200	mg/kg bw/day	LEL	oral	Rat	ToxValDB_Uterotrophic_Hershberger_DB
300	nM	LEL	-	-	NTP_ICE_endocrine
=21.55	mg/kg bw/day	LOAEL	oral	Rat	ToxValDB_ToxRefDB
=21.55	mg/kg bw/day	LOAEL	oral	rat (wistar; Wistar)	ToxRefDB_ToxRefDB_v3_pod.csv
=25	mg/kg bw/day	LOEL	injection	Rat	ToxValDB_ECOTOX

Showing 50 of 100 studies

EPA Toxic Release Inventory (TRI)

TRI hazard and reporting flags for the matched chemical.

SOURCE EPA Toxics Release Inventory (TRI) chemical list 1 records

Chemical	Category	Flags
Fenarimol	-	-

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

permitted

Max

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL FENARIMOL

ChEMBL Phase

Not listed

Adverse Events

Bioactivity

View full pharmaceutical profile →

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the GHS hazard classification for Fenarimol?

Fenarimol (CAS 60168-88-9) is classified under EU CLP Annex VI as Repr. 2; Lact.; Aquatic Chronic 2 with signal word Warning. Hazard statements: H361fd; H362; H411. Source: EU CLP Annex VI (ECHA).

What is the NOAEL for Fenarimol?

Fenarimol has 100 NOAEL studies in the database. The lowest reported value is 0 unitless. Source: NTP_ICE_endocrine.

What regulatory lists include Fenarimol?

Fenarimol appears on 7 regulatory/inventory lists including active_ingredient; agricultural; Pesticides, active_ingredient; Pesticides, active_ingredient; Europe; Pesticides, and 4 more. Source: EPA CPDat.

Is Fenarimol used in cosmetics?

Yes, Fenarimol is also indexed as a cosmetic ingredient under the name Quaternium-71. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Fenarimol come from?

Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, EPA DSSTox, EPA Toxics Release Inventory, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Does Fenarimol have different safety status in cosmetics vs industrial chemicals?

Fenarimol is classified GHS CMR hazard (H361fd, H362, H411) in the chemicals database but is allowed in EU cosmetics.

Is Fenarimol used outside industrial chemicals?

Fenarimol also appears in cosmetics, pharmaceutical, cannabis databases.