What is the NOAEL for Linoleic acid?
Linoleic acid has 18 NOAEL studies in the database. The lowest reported value is 0 unitless. Source: NTP_ICE_endocrine.
NOAEL Data
Cosmetic Ingredient
Linoleic acid
Also known as: EINECS 200-470-9, Emersol 310, NSC 281243, Polylin No. 515, alpha-Linoleic acid (+15 more)
CAS 60-33-3
Linoleic acid (CAS 60-33-3) is a chemical substance. Key regulatory status: 8 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat.
SOURCE
noael studies public
NOAEL studies
18
SOURCE
chemical inventory jurisdictions
Regulatory lists
8
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
26 fields
Name
Linoleic acid
CAS Number
60-33-3
DTXSID
DTXSID2025505
Molecular Formula
C18H32O2
InChI Key
OYHQOLUKZRVURQ-HZJYTTRNSA-N
Monoisotopic Mass
280.24023
Synonyms
EINECS 200-470-9Emersol 310NSC 281243Polylin No. 515alpha-Linoleic acidcis-delta9,12-Octadecadienoic acidUNII-9KJL21T0QJ(9Z,12Z)-9,12-Octadecadienoate(Z,Z)-9,12-Octadecadienoate9-cis,12-cis-Linoleate9Z,12Z-Linoleate9Z,12Z-Octadecadienoate
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
27 records
Surfactant (surface active agent)Softener and conditionerAnti-static agentCleaning agentFragranceFlavouring and nutrientNo specific technical functionProcessing aids not otherwise specified
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
8 records
| List | Keyword | Source |
|---|---|---|
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| supplements | Danish EPA | Danish EPA |
| IFRA Transparency | IFRA | IFRA |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| SCIL (9/2019) | USEPA | Safer Chemical Ingredients List |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Europe | European Commission | Fl@vis |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 18 of 18 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 29.1577135194153 | uM | AC50 | - | - | NTP_ICE_endocrine |
| 31.32125369 | uM | AC50 | - | - | NTP_ICE_endocrine |
| 23.4122562985266 | uM | ACC | - | - | NTP_ICE_endocrine |
| 25.18679274 | uM | ACC | - | - | NTP_ICE_endocrine |
| 14.1 | % | EC3 | Dermal | Mouse | NTP_ICE_skin_sensitization |
| 14.1 | % | EC3 | Dermal | Mouse | NTP_ICE_skin_sensitization |
| 14.1 | % | EC3 | Dermal | Mouse | NTP_ICE_skin_sensitization |
| 14.1 | % | EC3 | Dermal | Mouse | NTP_ICE_skin_sensitization |
| 9KJL21T0QJ | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 9KJL21T0QJ | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 9KJL21T0QJ | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 9KJL21T0QJ | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
| 0.00607 | unitless | Model Score | - | - | NTP_ICE_endocrine |
| 0.0121 | unitless | Model Score | - | - | NTP_ICE_endocrine |
| 0.0336 | unitless | Model Score | - | - | NTP_ICE_endocrine |
| =0.09 | mM | NOEL | environmental | European Rabbit | ToxValDB_ECOTOX |
| =0.9 | mM | NOEL | environmental | European Rabbit | ToxValDB_ECOTOX |
Showing 18 of 18 studies
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
active
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
LINOLEIC ACID
ChEMBL Phase
2
Adverse Events
8
Bioactivity
22
Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Linoleic acid?
Linoleic acid appears on 7 regulatory/inventory lists including inert_ingredient; non_food_use; Pesticides, supplements, IFRA Transparency, and 4 more. Source: EPA CPDat.
Is Linoleic acid used in cosmetics?
Yes, Linoleic acid is also indexed as a cosmetic ingredient under the name Linoleic Acid. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Linoleic acid come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is Linoleic acid used outside industrial chemicals?
Linoleic acid also appears in cosmetics, pharmaceutical, cannabis databases.