NOAEL Data Cosmetic Ingredient

1,2,3-Propanetricarboxylic acid, 2-hydroxy-, hydrate (1:1)

Also known as: Citric acid hydrate, Citric acid monohydrate, UNII-2968PHW8QP

CAS 5949-29-1

1,2,3-Propanetricarboxylic acid, 2-hydroxy-, hydrate (1:1) (CAS 5949-29-1) is a chemical substance. Key regulatory status: 5 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ILO ICSC.

View cosmetic safety profile for Citric Acid Hydrate →

SOURCE noael studies public

NOAEL studies

SOURCE chemical inventory jurisdictions

Regulatory lists

SOURCE eu clp annex vi

GHS signal

Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 9 fields

Name

1,2,3-Propanetricarboxylic acid, 2-hydroxy-, hydrate (1:1)

CAS Number

5949-29-1

DTXSID

DTXSID7074668

Molecular Formula

C6H8O7.H2O

InChI Key

YASYEJJMZJALEJ-UHFFFAOYSA-N

Monoisotopic Mass

210.037567

Synonyms

Citric acid hydrateCitric acid monohydrateUNII-2968PHW8QP

ICSC Chemical Safety

International Chemical Safety Card hazard and exposure summary.

SOURCE ILO/WHO International Chemical Safety Cards 1 records

Field	Value
Short-term Effects	The aerosol is irritating to the eyes, skin and respiratory tract.
Routes of Exposure	The substance can be absorbed into the body by inhalation of its aerosol and by ingestion.

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 2 records

pH regulating agentProcessing aids not otherwise specified

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 5 records

List	Keyword	Source
inert_ingredient; non_food_use; Pesticides	EPA	CPCat
active_ingredient; Europe; Pesticides	Commission of the European Communities	CPCat
Europe; Personal care - hair styling and care - shampoo-dandruff	Danish Environmental Protection Agency	Danish EPA
SCIL (9/2019)	USEPA	Safer Chemical Ingredients List
inert_ingredient; Pesticides	EPA	CPCat

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 17 of 17 studies

Value	Unit	Endpoint	Route	Species	Source
2968PHW8QP	UNII	FDA UNII substance identifier	-	-	openFDA substances
2968PHW8QP	UNII	FDA UNII substance identifier	-	-	openFDA substances
2968PHW8QP	UNII	FDA UNII substance identifier	-	-	openFDA substances
2968PHW8QP	UNII	FDA UNII substance identifier	-	-	openFDA substances
75	mg/kg bw/day	LOAEL	oral	rat	COSMOS_DB
300	mg/kg bw/day	LOAEL	oral	rat	COSMOS_DB
75	mg/kg bw/day	NOAEL	oral	rat	COSMOS_DB
200	mg/kg bw/day	NOAEL	oral	rat	COSMOS_DB
241	mg/kg bw/day	NOAEL	oral	mouse	COSMOS_DB
272	mg/kg bw/day	NOAEL	oral	hamster	COSMOS_DB
295	mg/kg bw/day	NOAEL	oral	rat	COSMOS_DB
425	mg/kg bw/day	NOAEL	oral	rabbit	COSMOS_DB
600	mg/kg bw/day	NOAEL	oral	rat	COSMOS_DB
800	mg/kg bw/day	NOAEL	oral	rat	COSMOS_DB
1380	mg/kg bw/day	NOAEL	oral	dog	COSMOS_DB
2000	mg/kg bw/day	NOAEL	oral	rat	COSMOS_DB
4670	mg/kg bw/day	NOAEL	oral	rat	COSMOS_DB

Showing 17 of 17 studies

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

permitted

Max

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL CITRIC ACID MONOHYDRATE

ChEMBL Phase

-1

Adverse Events

169

Bioactivity

View full pharmaceutical profile →

Frequently Asked Questions

What is the NOAEL for 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, hydrate (1:1)?

1,2,3-Propanetricarboxylic acid, 2-hydroxy-, hydrate (1:1) has 17 NOAEL studies in the database. The lowest reported value is 2968PHW8QP UNII. Source: openFDA substances.

What regulatory lists include 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, hydrate (1:1)?

1,2,3-Propanetricarboxylic acid, 2-hydroxy-, hydrate (1:1) appears on 5 regulatory/inventory lists including inert_ingredient; non_food_use; Pesticides, active_ingredient; Europe; Pesticides, Europe; Personal care - hair styling and care - shampoo-dandruff, and 2 more. Source: EPA CPDat.

Is 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, hydrate (1:1) used in cosmetics?

Yes, 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, hydrate (1:1) is also indexed as a cosmetic ingredient under the name Citric Acid Hydrate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, hydrate (1:1) come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.

Is 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, hydrate (1:1) used outside industrial chemicals?

1,2,3-Propanetricarboxylic acid, 2-hydroxy-, hydrate (1:1) also appears in cosmetics, pharmaceutical databases.