What is the NOAEL for Terpinolene?
Terpinolene has 17 NOAEL studies in the database. The lowest reported value is 3.6 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Terpinolene
Also known as: Cyclohexene, 1-methyl-4-(1-methylethylidene)-, EINECS 209-578-0, FEMA No. 3046, FEMA Number 3046, p-Menth-1,4(8)-diene (+14 more)
CAS 586-62-9
Terpinolene (CAS 586-62-9) is a chemical substance. Key regulatory status: REACH registered, 13 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
Cross-Vertical Regulatory Divergence
Terpinolene is classified GHS Danger (H226, H304, H315, H317, H400, H410, H411, H227) in the chemicals database but is restricted in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
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noael studies public
NOAEL studies
17
SOURCE
chemical inventory jurisdictions
Regulatory lists
13
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
25 fields
Name
Terpinolene
CAS Number
586-62-9
DTXSID
DTXSID0027222
Molecular Formula
C10H16
InChI Key
MOYAFQVGZZPNRA-UHFFFAOYSA-N
Monoisotopic Mass
136.125201
Synonyms
Cyclohexene, 1-methyl-4-(1-methylethylidene)-EINECS 209-578-0FEMA No. 3046FEMA Number 3046p-Menth-1,4(8)-diene1-Methyl-4-isopropylidene-1-cyclohexeneTereben1,4(8)-TerpadieneUNII-N9830X5KSL1,4(8)-p-menthadiene1-Methyl-4-(1-methylethylidene)-Cyclohexene1-Methyl-4-(1-methylethylidene)cyclohexene, 9CI
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
60 records
FragranceNo specific technical functionFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
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EPA CPDat
13 records
| List | Keyword | Source |
|---|---|---|
| active_ingredient; Europe; Pesticides | European Commission | CPCat |
| air; Cleaning products and household care - laundry and fabric treatment; detected; emissions | Elsevier | CPCat |
| air; detected; emissions; Personal care | Elsevier | CPCat |
| air; Cleaning products and household care; detected; emissions | Elsevier | CPCat |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| active_ingredient; Europe; Pesticides | Commission of the European Communities | CPCat |
| Australia; Food and drug - smoking-related products | New Zealand ESR | CPCat |
| IFRA Transparency | IFRA | IFRA |
| Europe | European Commission | Fl@vis |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| SCIL (9/2019) | USEPA | Safer Chemical Ingredients List |
| consumer_product | P&G | Proctor & Gamble |
| Europe; Personal care; restricted | European Commission | CosIng |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 17 of 17 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 69.4775145314972 | uM | AC50 | - | - | NTP_ICE_endocrine |
| 65.3108670446833 | uM | ACC | - | - | NTP_ICE_endocrine |
| =3.6 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| =5.88 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| N9830X5KSL | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| N9830X5KSL | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| N9830X5KSL | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| N9830X5KSL | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 13500 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| =4390 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
| 0.00827 | unitless | Model Score | - | - | NTP_ICE_endocrine |
| =294.6 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =312.5 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =371 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
Showing 17 of 17 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | p-mentha-1,4(8)-diene | 209-578-0 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
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AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
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CosIng / Ingredients DB
EU Status
restricted
Max
-
Category
Fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
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EMBL-EBI ChEMBL
TERPINOLENE
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
1
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
ADI: No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Terpinolene?
Terpinolene appears on 12 regulatory/inventory lists including active_ingredient; Europe; Pesticides, air; Cleaning products and household care - laundry and fabric treatment; detected; emissions, air; detected; emissions; Personal care, and 9 more. Source: EPA CPDat.
Is Terpinolene used in cosmetics?
Yes, Terpinolene is also indexed as a cosmetic ingredient under the name Terpinolene. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Terpinolene come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Does Terpinolene have different safety status in cosmetics vs industrial chemicals?
Terpinolene is classified GHS Danger (H226, H304, H315, H317, H400, H410, H411, H227) in the chemicals database but is restricted in EU cosmetics.
Is Terpinolene used outside industrial chemicals?
Terpinolene also appears in cosmetics, pharmaceutical, food safety, cannabis databases.