What is the NOAEL for Rebaudioside A?
Rebaudioside A has 4 NOAEL studies in the database. The lowest reported value is B3FUD0528F UNII. Source: openFDA substances.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Rebaudioside A
Also known as: Kaur-16-en-18-oic acid, 13-[(O-β-D-glucopyranosyl-(1→2)-O-[β-D-glucopyranosyl-(1→3)]-β-D-glucopyranosyl)oxy]-, β-D-glucopyranosyl ester, (4α)-, Rebaudioside-A, UNII-B3FUD0528F, 4G-S, Chrysanta AR-P (+11 more)
CAS 58543-16-1
Rebaudioside A (CAS 58543-16-1) is a chemical substance. Key regulatory status: REACH registered, 2 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, ECHA REACH.
SOURCE
noael studies public
NOAEL studies
4
SOURCE
chemical inventory jurisdictions
Regulatory lists
2
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
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DSSTox identifiers
22 fields
Name
Rebaudioside A
CAS Number
58543-16-1
DTXSID
DTXSID8047898
Molecular Formula
C44H70O23
InChI Key
HELXLJCILKEWJH-NCGAPWICSA-N
Monoisotopic Mass
966.430789
Synonyms
Kaur-16-en-18-oic acid, 13-[(O-β-D-glucopyranosyl-(1→2)-O-[β-D-glucopyranosyl-(1→3)]-β-D-glucopyranosyl)oxy]-, β-D-glucopyranosyl ester, (4α)-Rebaudioside-AUNII-B3FUD0528F4G-SChrysanta AR-PGlycoside A3, from Stevia rebaudianaGlycoside XPure ViaRA 95Reb-A 97Rebaudiana aRebiana
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
2 records
Softener and conditionerFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
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EPA CPDat
2 records
| List | Keyword | Source |
|---|---|---|
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| Canada; pharmaceutical | DrugBank | DrugBank |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 4 of 4 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| B3FUD0528F | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| B3FUD0528F | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| B3FUD0528F | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| B3FUD0528F | UNII | FDA UNII substance identifier | - | - | openFDA substances |
Showing 4 of 4 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 1-O-(13α-{[β-D-glucopyranosyl-(1→2)-[β-D-glucopyranosyl-(1→3)]-β-D-glucopyranosyl]oxy}-19-oxo-5β,8α,9β,10α-kaur-16-en-19-yl)-β-D-glucopyranose | 611-696-6 | ECHA overview → |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Skin Conditioning
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
E960a — ADI: 4 mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Rebaudioside A?
Rebaudioside A appears on 2 regulatory/inventory lists including food_additive; Substances Added to Food (formerly EAFUS) (2/2019), Canada; pharmaceutical. Source: EPA CPDat.
Is Rebaudioside A used in cosmetics?
Yes, Rebaudioside A is also indexed as a cosmetic ingredient under the name Rebaudioside A. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Rebaudioside A come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is Rebaudioside A used outside industrial chemicals?
Rebaudioside A also appears in cosmetics, food safety, cannabis databases.