What is the NOAEL for 1,2-Butanediol?
1,2-Butanediol has 8 NOAEL studies in the database. The lowest reported value is RUN0H01QEU UNII. Source: openFDA substances.
NOAEL Data
REACH Registered
Cosmetic Ingredient
1,2-Butanediol
Also known as: 4-01-00-02507, BRN 0969169, EINECS 209-527-2, UNII-RUN0H01QEU, 1,2-(Dihydroxy)butane (+3 more)
CAS 584-03-2
1,2-Butanediol (CAS 584-03-2) is a chemical substance. Key regulatory status: REACH registered, 1 regulatory/inventory list, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC.
SOURCE
noael studies public
NOAEL studies
8
SOURCE
chemical inventory jurisdictions
Regulatory lists
1
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
14 fields
Name
1,2-Butanediol
CAS Number
584-03-2
DTXSID
DTXSID6040375
Molecular Formula
C4H10O2
InChI Key
BMRWNKZVCUKKSR-UHFFFAOYSA-N
Monoisotopic Mass
90.06808
Synonyms
4-01-00-02507BRN 0969169EINECS 209-527-2UNII-RUN0H01QEU1,2-(Dihydroxy)butaneEthylethylene glycolalpha-Butylene glycolalpha-Butyleneglycol
ICSC Chemical Safety
International Chemical Safety Card hazard and exposure summary.
SOURCE
ILO/WHO International Chemical Safety Cards
1 records
| Field | Value |
|---|---|
| GHS Signal Word | WARNING |
| GHS Hazard Statements | Combustible liquid May be harmful if swallowed and enters airways |
| Short-term Effects | The substance is irritating to the eyes. Exposure at high levels could cause lowering of consciousness. If swallowed the substance easily enters the airways and could result in aspiration pneumonitis. |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
5 records
SolventHumectantSoftener and conditionerViscosity modifier
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
1 records
| List | Keyword | Source |
|---|---|---|
| SCIL (9/2019) | USEPA | Safer Chemical Ingredients List |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 8 of 8 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| RUN0H01QEU | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| RUN0H01QEU | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| RUN0H01QEU | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| RUN0H01QEU | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =16000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| 300 | mg/kg bw/day | LOEL | Oral | Rat | NTP_ICE_dart |
| =200 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| >=1000 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
Showing 8 of 8 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Butane-1,2-diol | 209-527-2 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Humectant
Frequently Asked Questions
What regulatory lists include 1,2-Butanediol?
1,2-Butanediol appears on 1 regulatory/inventory list including SCIL (9/2019). Source: EPA CPDat.
Is 1,2-Butanediol used in cosmetics?
Yes, 1,2-Butanediol is also indexed as a cosmetic ingredient under the name 1,2-Butanediol. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 1,2-Butanediol come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.
Is 1,2-Butanediol used outside industrial chemicals?
1,2-Butanediol also appears in cosmetics databases.