What is the NOAEL for Biotin?
Biotin has 17 NOAEL studies in the database. The lowest reported value is 6SO6U10H04 UNII. Source: openFDA substances.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Biotin
Also known as: D-(+)-Biotin, D-Biotin, Biotin (Vitamin H), EINECS 200-399-3, Hexahydro-2-oxo-1H-thieno(3,4-d)imidazole-4-pentanoic acid, (3aS-(3aalpha,4beta,6aalpha))- (+15 more)
CAS 58-85-5
Biotin (CAS 58-85-5) is a chemical substance. Key regulatory status: REACH registered, 13 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, ECHA REACH.
SOURCE
noael studies public
NOAEL studies
17
SOURCE
chemical inventory jurisdictions
Regulatory lists
13
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
26 fields
Name
Biotin
CAS Number
58-85-5
DTXSID
DTXSID7022679
Molecular Formula
C10H16N2O3S
InChI Key
YBJHBAHKTGYVGT-ZKWXMUAHSA-N
Monoisotopic Mass
244.088164
Synonyms
D-(+)-BiotinD-BiotinBiotin (Vitamin H)EINECS 200-399-3Hexahydro-2-oxo-1H-thieno(3,4-d)imidazole-4-pentanoic acid, (3aS-(3aalpha,4beta,6aalpha))-Injacom H2'-Keto-3,4-imidazolido-2-tetrahydrothiophene-N-valeric acidcis-Tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid1H-Thieno(3,4-d)imidazole-4-pentanoic acid, hexahydro-2-oxo-, (3aS-(3aalpha,4beta,6aalpha))-Vitamin Bwbeta-BiotinMedebiotin
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
38 records
Softener and conditionerPharmaceuticalChelating agentFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
13 records
| List | Keyword | Source |
|---|---|---|
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| pharmaceutical | US International Trade Commission | CPCat |
| active_ingredient; animal_products; Europe; pharmaceutical; residue | EU | CPCat |
| Europe; supplements | EU | CPCat |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Europe; supplements | EU | CPCat |
| Europe; food_additive; supplements | EU | CPCat |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 17 of 17 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 6SO6U10H04 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 6SO6U10H04 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 6SO6U10H04 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 6SO6U10H04 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
| 0.015 | mg/kg bw/day | NOAEL | oral | swine | COSMOS_DB |
| 0.02 | mg/kg bw/day | NOAEL | oral | swine | COSMOS_DB |
| 1 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 2.8 | mg/kg bw/day | NOAEL | oral | swine | COSMOS_DB |
| 4.4 | mg/kg bw/day | NOAEL | oral | swine | COSMOS_DB |
| 6.4 | mg/kg bw/day | NOAEL | oral | swine | COSMOS_DB |
| 6.5 | mg/kg bw/day | NOAEL | oral | swine | COSMOS_DB |
| 35 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 50 | mg/kg bw/day | NOAEL | oral | mouse | COSMOS_DB |
| 150 | mg/kg bw/day | NOAEL | oral | mouse | COSMOS_DB |
| 360 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 896 | mg/kg bw/day | NOAEL | oral | mouse | COSMOS_DB |
Showing 17 of 17 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Biotin | 200-399-3 | ECHA overview → |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
active
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
BIOTIN
ChEMBL Phase
4
Adverse Events
3120
Bioactivity
6
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
1 food-safety record found.
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Biotin?
Biotin appears on 8 regulatory/inventory lists including inert_ingredient; non_food_use; Pesticides, pharmaceutical, active_ingredient; animal_products; Europe; pharmaceutical; residue, and 5 more. Source: EPA CPDat.
Is Biotin used in cosmetics?
Yes, Biotin is also indexed as a cosmetic ingredient under the name Biotin. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Biotin come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is Biotin used outside industrial chemicals?
Biotin also appears in cosmetics, pharmaceutical, food safety, cannabis databases.