What is the GHS hazard classification for Caffeine?
Caffeine (CAS 58-08-2) is classified under EU CLP Annex VI as Acute Tox. 4 * with signal word Warning. Hazard statements: H302. Source: EU CLP Annex VI (ECHA).
Warning
GHS07
NOAEL Data
IARC Group 3
REACH Registered
Cosmetic Ingredient
Caffeine
Also known as: 1H-Purine-2,6-dione, 3,7-dihydro-1,3,7-trimethyl-, 5-26-13-00558, Anhydrous caffeine, BRN 0017705, Cafamil (+14 more)
CAS 58-08-2
Caffeine (CAS 58-08-2) is a chemical substance with GHS signal word Warning; key hazard signal: H302. Key regulatory status: REACH registered, 49 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, IARC, ECHA REACH, ILO ICSC.
SOURCE
noael studies public
NOAEL studies
94
SOURCE
chemical inventory jurisdictions
Regulatory lists
49
SOURCE
eu clp annex vi
GHS signal
Warning
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
25 fields
Name
Caffeine
CAS Number
58-08-2
DTXSID
DTXSID0020232
Molecular Formula
C8H10N4O2
InChI Key
RYYVLZVUVIJVGH-UHFFFAOYSA-N
Monoisotopic Mass
194.080376
Synonyms
1H-Purine-2,6-dione, 3,7-dihydro-1,3,7-trimethyl-5-26-13-00558Anhydrous caffeineBRN 0017705CafamilCafeconCaffeine, syntheticCaffineCoffeineCoffeinumDexitacEINECS 200-362-1
IARC Carcinogen Classification
Carcinogenic hazard classification from IARC monograph evaluations.
SOURCE
IARC Monographs on the Identification of Carcinogenic Hazards to Humans
1 records
| Group | Meaning | Evaluated | Volume |
|---|---|---|---|
| Group 3 | Not classifiable | 1990 | 51 |
GHS / CLP Classification
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
SOURCE
EU CLP Annex VI (ECHA)
1 classifications
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Acute Tox. 4 * | H302 | GHS07 | Warning |
ICSC Chemical Safety
International Chemical Safety Card hazard and exposure summary.
SOURCE
ILO/WHO International Chemical Safety Cards
1 records
| Field | Value |
|---|---|
| Short-term Effects | The substance may cause effects on the central nervous system and cardiovascular system. This may result in insomnia, excitement, tachycardia and polyuria. |
| Routes of Exposure | The substance can be absorbed into the body by inhalation and by ingestion. |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
17 records
DeodorizerSoftener and conditionerPharmaceuticalFragranceFlavouring and nutrientBiocide
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
49 records
| List | Keyword | Source |
|---|---|---|
| active_ingredient; Australia | Australian Pesticides and Veterinary Medicines Authority | CPCat |
| pharmaceutical | FDA | United States Food and Drug Administration (FDA) |
| active_ingredient; Europe; Pesticides | Commission of the European Communities | CPCat |
| active_ingredient; animal_products; Europe; pharmaceutical; residue | EU | CPCat |
| Europe; pharmaceutical | European Medicines Agency | PROTECT ADR database |
| pharmaceutical | DEA | U.S. Drug Enforcement Administration (DEA) |
| pharmaceutical | DEA | U.S. Drug Enforcement Administration (DEA) |
| pharmaceutical | DEA | U.S. Drug Enforcement Administration (DEA) |
| pharmaceutical | DEA | U.S. Drug Enforcement Administration (DEA) |
| pharmaceutical | DEA | U.S. Drug Enforcement Administration (DEA) |
| pharmaceutical | DEA | U.S. Drug Enforcement Administration (DEA) |
| pharmaceutical | DEA | U.S. Drug Enforcement Administration (DEA) |
| pharmaceutical | DEA | U.S. Drug Enforcement Administration (DEA) |
| pharmaceutical | DEA | U.S. Drug Enforcement Administration (DEA) |
| pharmaceutical | DEA | U.S. Drug Enforcement Administration (DEA) |
| pharmaceutical | DEA | U.S. Drug Enforcement Administration (DEA) |
| detected; drinking_water | Illinois EPA | CPCat |
| detected; drinking_water | Illinois EPA | CPCat |
| detected; pharmaceutical; wastewater | USGS | United States Geological Survey (USGS) |
| detected; pharmaceutical; soil | USGS | United States Geological Survey (USGS) |
| Europe; pharmaceutical | Drinking Water Inspectorate | CPCat |
| detected; MN Chemical Screening; pharmaceutical; surface_water | Minnesota Pollution Control Agency | State of Minnesota |
| detected; MN Chemical Screening; surface_water | Minnesota Pollution Control Agency | State of Minnesota |
| detected; MN Chemical Screening; pharmaceutical; surface_water | Minnesota Pollution Control Agency | State of Minnesota |
| detected; MN Chemical Screening; surface_water | USGS | State of Minnesota |
| detected; MN Chemical Screening; surface_water | USGS | State of Minnesota |
| detected; drinking_water; MN Chemical Screening | National Parks Service | State of Minnesota |
| detected; MN Chemical Screening; surface_water | National Parks Service | State of Minnesota |
| detected; ground_water; MN Chemical Screening; pharmaceutical | USGS | State of Minnesota |
| detected; ground_water; MN Chemical Screening; pharmaceutical | USGS | State of Minnesota |
| detected; MN Chemical Screening; surface_water | Minnesota Pollution Control Agency | State of Minnesota |
| detected; MN Chemical Screening; wastewater | Minnesota Pollution Control Agency | State of Minnesota |
| detected; MN Chemical Screening; surface_water | Minnesota Pollution Control Agency | State of Minnesota |
| detected; MN Chemical Screening; surface_water | Minnesota Pollution Control Agency | State of Minnesota |
| detected; MN Chemical Screening; wastewater | Minnesota Pollution Control Agency | State of Minnesota |
| detected; drinking_water; MN Chemical Screening | USGS | State of Minnesota |
| detected; drinking_water; MN Chemical Screening | USGS | State of Minnesota |
| detected; ground_water; MN Chemical Screening | Minnesota Pollution Control Agency | State of Minnesota |
| detected; drinking_water; MN Chemical Screening | EPA & USGS | State of Minnesota |
| detected; drinking_water; MN Chemical Screening | EPA & USGS | State of Minnesota |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 50 of 94 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 0.2855 | uL/min/10^6 cells | Clint | - | Human | NTP_ICE_adme_parameters |
| 1.458 | uL/min/10^6 cells | Clint | - | Rat | NTP_ICE_adme_parameters |
| =44.37 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 3G6A5W338E | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 3G6A5W338E | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 3G6A5W338E | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 3G6A5W338E | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0.7335 | fraction | Fu | - | Rat | NTP_ICE_adme_parameters |
| 1 | fraction | Fu | - | Human | NTP_ICE_adme_parameters |
| 3 | IARC group | IARC carcinogenicity classification | - | - | IARC Monographs |
| 3 | unitless | IARC group | - | - | NTP_ICE_cancer |
| =192 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =192 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =192 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =192 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =367 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =367 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =367 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =367 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| ~35 | mg/kg bw/day | LEL | oral | Mouse | ToxValDB_ECHA_IUCLID |
| =220 | mg/kg bw/day | LEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =240 | mg/kg bw/day | LEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| 21 | mg/kg bw/day | LOAEL | oral | rat | COSMOS_DB |
| 23 | mg/kg bw/day | LOAEL | oral | mouse | COSMOS_DB |
| 29 | mg/kg bw/day | LOAEL | oral | rat | COSMOS_DB |
| 100 | mg/kg bw/day | LOAEL | oral | rat | COSMOS_DB |
| =20 | mg/kg bw/day | LOEL | oral | Rat | ToxValDB_ECOTOX |
| =30 | mg/L | LOEL | environmental | Rat | ToxValDB_ECOTOX |
| =300 | mg/L | LOEL | environmental | Rat | ToxValDB_ECOTOX |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
| 3 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 6 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 10 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 12.5 | mg/kg bw/day | NOAEL | oral | monkey | COSMOS_DB |
| <12.5 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| 13 | mg/kg bw/day | NOAEL | oral | monkey | COSMOS_DB |
| 15 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 20 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| =22 | mg/kg bw/day | NOAEL | oral | Mouse | ToxValDB_ECHA_IUCLID |
| 22.5 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 24.7 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 25 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 26.4 | mg/kg bw/day | NOAEL | oral | mouse | COSMOS_DB |
| 28 | mg/kg bw/day | NOAEL | oral | monkey | COSMOS_DB |
| 29 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 30 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 32.5 | mg/kg bw/day | NOAEL | oral | rabbit | COSMOS_DB |
| 35 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 36 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 37 | mg/kg bw/day | NOAEL | oral | swine | COSMOS_DB |
Showing 50 of 94 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Caffeine | 200-362-1 | ECHA overview → |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
6% leave-on body, 1.5% eye lotions, 2% face powder
Category
active
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CAFFEINE
ChEMBL Phase
4
Adverse Events
3536
Bioactivity
24
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
2 records
FDA GRAS: At the notifier's request, FDA ceased to evaluate this notice
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What is the NOAEL for Caffeine?
Caffeine has 94 NOAEL studies in the database. The lowest reported value is 0.2855 uL/min/10^6 cells in Human. Source: NTP_ICE_adme_parameters.
What regulatory lists include Caffeine?
Caffeine appears on 20 regulatory/inventory lists including active_ingredient; Australia, pharmaceutical, active_ingredient; Europe; Pesticides, and 17 more. Source: EPA CPDat.
Is Caffeine a carcinogen according to IARC?
Caffeine is classified by IARC as Group 3 — not classifiable as to its carcinogenicity to humans (evaluated 1990). Source: IARC Monographs on the Identification of Carcinogenic Hazards to Humans.
Is Caffeine used in cosmetics?
Yes, Caffeine is also indexed as a cosmetic ingredient under the name Caffeine. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Caffeine come from?
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, EPA DSSTox, IARC Monographs, ECHA REACH, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is Caffeine used outside industrial chemicals?
Caffeine also appears in cosmetics, pharmaceutical, food safety, cannabis databases.