What is the NOAEL for Docusate sodium?
Docusate sodium has 72 NOAEL studies in the database. The lowest reported value is 0 s via Ocular. Source: NTP_ICE_eye_irritation.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Docusate sodium
Also known as: Butanedioic acid, sulfo-, 1,4-bis(2-ethylhexyl) ester, sodium salt, Bis(2-ethylhexyl) sodium sulfosuccinate, Butanedioic acid, sulfo-, 1,4-dioctyl ester, sodium salt, Bis(ethylhexyl) ester of sodium sulfosuccinic acid, Bis(2-ethylhexyl)sodium sulfosuccinate (+15 more)
CAS 577-11-7
Docusate sodium (CAS 577-11-7) is a chemical substance. Key regulatory status: REACH registered, 16 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
View cosmetic safety profile for Diethylhexyl Sodium Sulfosuccinate →
Cross-Vertical Regulatory Divergence
Docusate sodium is classified GHS Danger (H302, H315, H318, H319, H361, H362, H402, H412) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
72
SOURCE
chemical inventory jurisdictions
Regulatory lists
16
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
25 fields
Name
Docusate sodium
CAS Number
577-11-7
DTXSID
DTXSID8022959
Molecular Formula
C20H38O7S.Na
InChI Key
APSBXTVYXVQYAB-UHFFFAOYSA-M
Synonyms
Butanedioic acid, sulfo-, 1,4-bis(2-ethylhexyl) ester, sodium saltBis(2-ethylhexyl) sodium sulfosuccinateButanedioic acid, sulfo-, 1,4-dioctyl ester, sodium saltBis(ethylhexyl) ester of sodium sulfosuccinic acidBis(2-ethylhexyl)sodium sulfosuccinateClestolDioctyl ester of sodium sulfosuccinateDioctyl ester of sodium sulfosuccinic acidEINECS 209-406-42-Ethylhexyl sulfosuccinate sodiumLaxinate 100Manoxal OT
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
41 records
Surfactant (surface active agent)Solubility enhancerEmulsifierCleaning agentPigmentFragranceAnti-adhesive/cohesiveWetting agent (non-aqueous)Dispersing agentAnti-static agentFlow promoter
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
16 records
| List | Keyword | Source |
|---|---|---|
| IFRA Transparency | IFRA | IFRA |
| Europe; Specialty occupational products | Danish Environmental Protection Agency | Danish EPA |
| Europe; Specialty occupational products | Danish Environmental Protection Agency | Danish EPA |
| pharmaceutical | US International Trade Commission | CPCat |
| Europe; plastic_additive | European Chemicals Agency | European Chemicals Agency (ECHA) |
| Arts and crafts/Office supplies - fabric treatment and dye; detected | Danish Environmental Protection Agency | Danish EPA |
| inert_ingredient; Pesticides | EPA | CPCat |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 50 of 72 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 19.35717708 | uM | AC50 | - | - | NTP_ICE_endocrine |
| 19.08508423 | uM | ACC | - | - | NTP_ICE_endocrine |
| 49.8 | uL/min/10^6 cells | Clint | - | Human | NTP_ICE_adme_parameters |
| =1889.1 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 57 | unitless | Draize rabbit irritation score | Ocular | Rabbit | NTP_ICE_eye_irritation |
| 57 | unitless | Draize rabbit irritation score | Ocular | Rabbit | NTP_ICE_eye_irritation |
| 57 | unitless | Draize rabbit irritation score | Ocular | Rabbit | NTP_ICE_eye_irritation |
| 57 | unitless | Draize rabbit irritation score | Ocular | Rabbit | NTP_ICE_eye_irritation |
| F05Q2T2JA0 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| F05Q2T2JA0 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| F05Q2T2JA0 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| F05Q2T2JA0 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 1 | unitless | GHS Classification | Ocular | Rabbit | NTP_ICE_eye_irritation |
| 1 | unitless | GHS Classification | Ocular | Rabbit | NTP_ICE_eye_irritation |
| 1 | unitless | GHS Classification | Ocular | Rabbit | NTP_ICE_eye_irritation |
| 1 | unitless | GHS Classification | Ocular | Rabbit | NTP_ICE_eye_irritation |
| 0.24 | %/sec | Intensity | Ocular | - | NTP_ICE_eye_irritation |
| 0.24 | %/sec | Intensity | Ocular | - | NTP_ICE_eye_irritation |
| 0.24 | %/sec | Intensity | Ocular | - | NTP_ICE_eye_irritation |
| 0.24 | %/sec | Intensity | Ocular | - | NTP_ICE_eye_irritation |
| =0.5 | % | LOEL | oral | Rat | ToxValDB_ECOTOX |
| =260 | mg/kg bw/day | LOEL | oral | Rat | ToxValDB_ECOTOX |
| =1500 | mg/kg bw/day | LOEL | oral | Rat | ToxValDB_ECOTOX |
| =10000 | ppm | LOEL | oral | Rat | ToxValDB_ECOTOX |
| - | s | Lag time | Ocular | - | NTP_ICE_eye_irritation |
| - | s | Lag time | Ocular | - | NTP_ICE_eye_irritation |
| - | s | Lag time | Ocular | - | NTP_ICE_eye_irritation |
| - | s | Lag time | Ocular | - | NTP_ICE_eye_irritation |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
| 0.124 | unitless | Model Score | - | - | NTP_ICE_endocrine |
| =0.5 | % | NOAEL | oral | rat | CIR_vision_codex |
| =0.5 | % | NOAEL | oral | rat | CIR_vision_codex |
| =0.5 | % | NOAEL | oral | rat | CIR_vision_codex |
| =0.5 | % | NOAEL | oral | rat | CIR_vision_codex |
| =1 | % | NOAEL | oral | rat | CIR_vision_codex |
| =1 | % | NOAEL | oral | rat | CIR_vision_codex |
| =1 | % | NOAEL | oral | rat | CIR_vision_codex |
| =1 | % | NOAEL | oral | rat | CIR_vision_codex |
| 30 | mg/kg bw/day | NOAEL | oral | dog | COSMOS_DB |
| >30 | mg/kg bw | NOAEL | inhalation | rabbit | CIR_vision_codex |
| >30 | mg/kg bw | NOAEL | inhalation | rabbit | CIR_vision_codex |
| >30 | mg/kg bw | NOAEL | inhalation | rabbit | CIR_vision_codex |
| >30 | mg/kg bw | NOAEL | inhalation | rabbit | CIR_vision_codex |
| =50 | % | NOAEL | oral | rat | CIR_vision_codex |
| =50 | % | NOAEL | oral | rat | CIR_vision_codex |
| =50 | % | NOAEL | oral | rat | CIR_vision_codex |
| =50 | % | NOAEL | oral | rat | CIR_vision_codex |
| 63 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| =400 | mg/kg bw | NOAEL | oral | rat | CIR_vision_codex |
| =400 | mg/kg bw | NOAEL | oral | rat | CIR_vision_codex |
Showing 50 of 72 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Docusate sodium | 209-406-4 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Surfactant
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
DOCUSATE SODIUM
ChEMBL Phase
3
Adverse Events
1696
Bioactivity
1
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
E480 — ADI: 0-0.1 mg/kg bw mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Docusate sodium?
Docusate sodium appears on 7 regulatory/inventory lists including IFRA Transparency, Europe; Specialty occupational products, pharmaceutical, and 4 more. Source: EPA CPDat.
Is Docusate sodium used in cosmetics?
Yes, Docusate sodium is also indexed as a cosmetic ingredient under the name Diethylhexyl Sodium Sulfosuccinate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Docusate sodium come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Does Docusate sodium have different safety status in cosmetics vs industrial chemicals?
Docusate sodium is classified GHS Danger (H302, H315, H318, H319, H361, H362, H402, H412) in the chemicals database but is allowed in EU cosmetics.
Is Docusate sodium used outside industrial chemicals?
Docusate sodium also appears in cosmetics, pharmaceutical, food safety, cannabis databases.