What is the NOAEL for Urea?
Urea has 25 NOAEL studies in the database. The lowest reported value is 292 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Urea
Also known as: Aqua Care HP, Caswell No. 902, EINECS 200-315-5, EPA Pesticide Chemical Code 085702, NCI-C02119 (+15 more)
CAS 57-13-6
Urea (CAS 57-13-6) is a chemical substance. Key regulatory status: REACH registered, 43 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, ECHA REACH, ILO ICSC.
SOURCE
noael studies public
NOAEL studies
25
SOURCE
chemical inventory jurisdictions
Regulatory lists
43
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
26 fields
Name
Urea
CAS Number
57-13-6
DTXSID
DTXSID4021426
Molecular Formula
CH4N2O
InChI Key
XSQUKJJJFZCRTK-UHFFFAOYSA-N
Monoisotopic Mass
60.032363
Synonyms
Aqua Care HPCaswell No. 902EINECS 200-315-5EPA Pesticide Chemical Code 085702NCI-C02119Prespersion, 75 ureaSupercel 3000Ultra MideUreacin-40 CremeUreacin-10 lotionSterile ureaUNII-8W8T17847W
ICSC Chemical Safety
International Chemical Safety Card hazard and exposure summary.
SOURCE
ILO/WHO International Chemical Safety Cards
1 records
| Field | Value |
|---|---|
| Short-term Effects | The substance is irritating to the eyes, skin and respiratory tract. |
| Long-term Effects | Repeated or prolonged contact with skin may cause dermatitis. |
| Routes of Exposure | The substance can be absorbed into the body by inhalation of its aerosol and by ingestion. |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
60 records
pH regulating agentHumectantAnti-static agentSoftener and conditionerNo specific technical functionSoil amendmentsFlame retardantBinderFreeze-thaw additiveFragranceOther
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
43 records
| List | Keyword | Source |
|---|---|---|
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | California Department of Pesticide Regulation | State of California |
| active_ingredient; Europe; Pesticides | European Commission | CPCat |
| active_ingredient; Australia | Australian Pesticides and Veterinary Medicines Authority | CPCat |
| inert_ingredient; Pesticides | EPA | CPCat |
| inert_ingredient; Pesticides | EPA | CPCat |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| Arts and crafts/Office supplies - fabric treatment and dye; detected | Danish Environmental Protection Agency | Danish EPA |
| Arts and crafts/Office supplies - fabric treatment and dye; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
| active_ingredient; Europe; Pesticides | Commission of the European Communities | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; animal_products; Europe; pharmaceutical; residue | EU | CPCat |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care - specialized bath products - bath salts | Danish Environmental Protection Agency | Danish EPA |
| Australia; Food and drug - smoking-related products | New Zealand ESR | CPCat |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| IFRA Transparency | IFRA | IFRA |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| SCIL (9/2019) | USEPA | Safer Chemical Ingredients List |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 25 of 25 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =292 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| =3526 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 8W8T17847W | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 8W8T17847W | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 8W8T17847W | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 8W8T17847W | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =8471 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =14300 | mg/kg bw | LD50 | oral | Rat (Male) | NTP_ICE_acute_oral |
| =15000 | mg/kg bw | LD50 | oral | Rat (Female) | NTP_ICE_acute_oral |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
| 160 | mg/kg bw/day | NOAEL | oral | sheep | COSMOS_DB |
| 230 | mg/kg bw/day | NOAEL | oral | cattle | COSMOS_DB |
| 440 | mg/kg bw/day | NOAEL | oral | cattle | COSMOS_DB |
| 900 | mg/kg bw/day | NOAEL | oral | mouse | COSMOS_DB |
| 2000 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 2250 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 3309 | mg/kg bw/day | NOAEL | oral | horse | COSMOS_DB |
| =3510 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| 5000 | mg/kg bw/day | NOAEL | oral | rabbit | COSMOS_DB |
| 6750 | mg/kg bw/day | NOAEL | oral | mouse | COSMOS_DB |
| =8325 | mg/kg bw/day | NOAEL | oral | Mouse | ToxValDB_ECHA_IUCLID |
| 50000 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| =2250 | mg/kg bw/day | NOEL | oral | Rat | ToxValDB_EFSA |
| =2250 | mg/kg bw/day | NOEL | - | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| =2250 | mg/kg bw/day | NOEL | - | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
Showing 25 of 25 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Urea | 200-315-5 | ECHA overview → |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
No concentration restriction for cosmetic use; ≥10% exerts keratolytic activity — label accordingly; ≥30% debriding use requires appropriate regulatory framing
Category
humectant
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
UREA
ChEMBL Phase
4
Adverse Events
691
Bioactivity
4
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
ADI: NOT SPECIFIED mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Urea?
Urea appears on 17 regulatory/inventory lists including active_ingredient; Pesticides, active_ingredient; Europe; Pesticides, active_ingredient; Australia, and 14 more. Source: EPA CPDat.
Is Urea used in cosmetics?
Yes, Urea is also indexed as a cosmetic ingredient under the name Urea. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Urea come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, ECHA REACH, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is Urea used outside industrial chemicals?
Urea also appears in cosmetics, pharmaceutical, food safety, cannabis databases.