NOAEL Data REACH Registered Cosmetic Ingredient

Octadecanoic acid

Also known as: Stearic acid, 4-02-00-01206, BRN 0608585, Caswell No. 801D, Dar-chem 14 (+15 more)

CAS 57-11-4

Octadecanoic acid (CAS 57-11-4) is a chemical substance. Key regulatory status: REACH registered, 28 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, ECHA REACH, ILO ICSC, OSHA.

View cosmetic safety profile for Stearic Acid →

SOURCE noael studies public

NOAEL studies

SOURCE chemical inventory jurisdictions

Regulatory lists

SOURCE eu clp annex vi

GHS signal

Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 26 fields

Name

Octadecanoic acid

CAS Number

57-11-4

DTXSID

DTXSID8021642

Molecular Formula

C18H36O2

InChI Key

QIQXTHQIDYTFRH-UHFFFAOYSA-N

Monoisotopic Mass

284.27153

Synonyms

Stearic acid4-02-00-01206BRN 0608585Caswell No. 801DDar-chem 14EINECS 200-313-4Emersol 132Emersol 150EPA Pesticide Chemical Code 079082FEMA No. 3035Formula 300Glycon S-70

ICSC Chemical Safety

International Chemical Safety Card hazard and exposure summary.

SOURCE ILO/WHO International Chemical Safety Cards 1 records

Field	Value
Routes of Exposure	The substance can be absorbed into the body by inhalation of its aerosol and by ingestion.

OSHA Exposure Limits

Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.

SOURCE OSHA / NIOSH / ACGIH occupational exposure limits 1 records

Agency	Metric	Value	ppm	mg/m3	Skin
ACGIH	TWA	10 mg/m³ (inhalable particulate matter); 5 mg/m³ (respirable particulate matter) [2016]	-	10	N

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 60 records

EmulsifierProcessing aids not otherwise specifiedSurfactant (surface active agent)DeodorizerCleaning agentFragranceLubricating agentPlasticizerFlavouring and nutrientSoftener and conditionerAnti-adhesive/cohesive

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 28 records

List	Keyword	Source
Canada; consumer_product; Substances in Products - Canada (4/2014)	Government of Canada	CPCat
inert_ingredient; Pesticides	EPA	CPCat
inert_ingredient; non_food_use; Pesticides	EPA	CPCat
Arts and crafts/Office supplies - children's art and toys - modeling clay; detected; Europe	Danish Environmental Protection Agency	Danish EPA
Cleaning products and household care - air freshener; Europe	Danish Environmental Protection Agency	Danish EPA
detected; Europe; Toys and children's products	Danish Environmental Protection Agency	Danish EPA
detected; Europe; Toys and children's products	Danish Environmental Protection Agency	Danish EPA
Europe	European Commission	Fl@vis
pharmaceutical	US International Trade Commission	CPCat
drinking_water; Europe; manufacturing; plastic_additive	Belgaqua	CPCat
inert_ingredient; Pesticides	EPA	CPCat
children; Europe; Personal care	Danish Environmental Protection Agency	Danish EPA
children; Europe; Personal care	Danish Environmental Protection Agency	Danish EPA
children; Europe; Personal care - general moisturizing - hand/body lotion	Danish Environmental Protection Agency	Danish EPA
Europe; Road vehicles	Danish Environmental Protection Agency	Danish EPA
Europe; Personal care - liniment	Danish Environmental Protection Agency	Danish EPA
Europe; Other direct contact consumer goods	Danish Environmental Protection Agency	Danish EPA
Europe; plastic_additive	European Chemicals Agency	European Chemicals Agency (ECHA)
Europe; Personal care	Danish Environmental Protection Agency	Danish EPA
Europe; Personal care	Danish Environmental Protection Agency	Danish EPA
Europe; Personal care	Danish Environmental Protection Agency	Danish EPA
IFRA Transparency	IFRA	IFRA
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)	FDA	United States Food and Drug Administration (FDA)
SCIL (9/2019)	USEPA	Safer Chemical Ingredients List
Canada; pharmaceutical	DrugBank	DrugBank
Canada; pharmaceutical	DrugBank	DrugBank
consumer_product	P&G	Proctor & Gamble
Cleaning products and household care - laundry and fabric treatment - laundry detergent; Europe	Danish EPA	Danish EPA

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 21 of 21 studies

Value	Unit	Endpoint	Route	Species	Source
7.24600862010455	uM	AC50	-	-	NTP_ICE_endocrine
2.50574742502705	uM	ACC	-	-	NTP_ICE_endocrine
=17.632	mg/m3	DNEL systemic	inhalation	Human	ToxValDB_GESTIS_DNEL
4ELV7Z65AP	UNII	FDA UNII substance identifier	-	-	openFDA substances
4ELV7Z65AP	UNII	FDA UNII substance identifier	-	-	openFDA substances
4ELV7Z65AP	UNII	FDA UNII substance identifier	-	-	openFDA substances
4ELV7Z65AP	UNII	FDA UNII substance identifier	-	-	openFDA substances
-	%	Incidence of positive responses	Dermal	Human	NTP_ICE_skin_sensitization
4725	ug/cm2	Induction dose per skin area	Dermal	Human	NTP_ICE_skin_sensitization
=4600	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
=0.09	mM	LOEL	environmental	European Rabbit	ToxValDB_ECOTOX
=0.9	mM	LOEL	environmental	European Rabbit	ToxValDB_ECOTOX
-	unitless	Model Score	-	-	NTP_ICE_endocrine
0.248	unitless	Model Score	-	-	NTP_ICE_endocrine
300	mg/kg bw/day	NOAEL	oral	rat	COSMOS_DB
=450	mg/kg bw/day	NOAEL	oral: gavage	Rat	EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx
=450	mg/kg bw/day	NOAEL	oral: gavage	Rat	EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx
3000	mg/kg bw/day	NOAEL	oral	rat	COSMOS_DB
3200	mg/kg bw/day	NOAEL	oral	rat	COSMOS_DB
10000	mg/kg bw/day	NOAEL	oral	rat	COSMOS_DB
3	unitless	Relative reliability score	Dermal	Human	NTP_ICE_skin_sensitization

Showing 21 of 21 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records

Status	Name	EC Number	Link
Registered	Stearic acid	200-313-4	ECHA overview →

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

permitted

Max

20-40%

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL STEARIC ACID

ChEMBL Phase

-1

Adverse Events

694

Bioactivity

View full pharmaceutical profile →

Food Safety Data

Same-CAS food additive, ADI, and GRAS records where available.

SOURCE EFSA / FDA GRAS 1 records

E570 — 1 food-safety record found.

View full food safety profile →

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the NOAEL for Octadecanoic acid?

Octadecanoic acid has 21 NOAEL studies in the database. The lowest reported value is 2.50574742502705 uM. Source: NTP_ICE_endocrine.

What regulatory lists include Octadecanoic acid?

Octadecanoic acid appears on 22 regulatory/inventory lists including Canada; consumer_product; Substances in Products - Canada (4/2014), inert_ingredient; Pesticides, inert_ingredient; non_food_use; Pesticides, and 19 more. Source: EPA CPDat.

What are the occupational exposure limits for Octadecanoic acid?

Occupational exposure limits for Octadecanoic acid are set by ACGIH. 1 limit value from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.

Is Octadecanoic acid used in cosmetics?

Yes, Octadecanoic acid is also indexed as a cosmetic ingredient under the name Stearic Acid. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Octadecanoic acid come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, ECHA REACH, ILO/WHO ICSC, OSHA/NIOSH/ACGIH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Is Octadecanoic acid used outside industrial chemicals?

Octadecanoic acid also appears in cosmetics, pharmaceutical, food safety, cannabis databases.