What is the NOAEL for Hexadecanoic acid?
Hexadecanoic acid has 14 NOAEL studies in the database. The lowest reported value is 17.632 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Hexadecanoic acid
Also known as: Palmitic acid, 4-02-00-01157, BRN 0607489, EINECS 200-312-9, FEMA No. 2832 (+14 more)
CAS 57-10-3
Hexadecanoic acid (CAS 57-10-3) is a chemical substance. Key regulatory status: REACH registered, 25 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, ECHA REACH, ILO ICSC.
SOURCE
noael studies public
NOAEL studies
14
SOURCE
chemical inventory jurisdictions
Regulatory lists
25
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
25 fields
Name
Hexadecanoic acid
CAS Number
57-10-3
DTXSID
DTXSID2021602
Molecular Formula
C16H32O2
InChI Key
IPCSVZSSVZVIGE-UHFFFAOYSA-N
Monoisotopic Mass
256.24023
Synonyms
Palmitic acid4-02-00-01157BRN 0607489EINECS 200-312-9FEMA No. 2832Palmitic acid 95%UNII-2V16EO95H11-hexyldecanoic acid16:00C16C16 fatty acidC16:0
ICSC Chemical Safety
International Chemical Safety Card hazard and exposure summary.
SOURCE
ILO/WHO International Chemical Safety Cards
1 records
| Field | Value |
|---|---|
| Routes of Exposure | The substance can be absorbed into the body by inhalation of its aerosol and by ingestion. |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
56 records
Surfactant (surface active agent)Softener and conditionerEmulsifierFragranceOpaciferAnti-adhesive/cohesiveFlavouring and nutrientLubricating agentProcessing aids not otherwise specifiedPlasticizer
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
25 records
| List | Keyword | Source |
|---|---|---|
| Canada; consumer_product; Substances in Products - Canada (4/2014) | Government of Canada | CPCat |
| inert_ingredient; Pesticides | EPA | CPCat |
| inert_ingredient; Pesticides | EPA | CPCat |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| Arts and crafts/Office supplies - children's art and toys - modeling clay; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
| air; Arts and crafts/Office supplies - children's art and toys - modeling clay; detected; emissions; Europe | Danish Environmental Protection Agency | Danish EPA |
| Cleaning products and household care - air freshener; Europe | Danish Environmental Protection Agency | Danish EPA |
| air; Cleaning products and household care - air freshener; detected; emissions; Europe | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
| Europe | European Commission | Fl@vis |
| detected; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
| pharmaceutical | US International Trade Commission | CPCat |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Europe; plastic_additive | European Chemicals Agency | European Chemicals Agency (ECHA) |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| detected; Toys and children's products | American Public Health Association | Published Articles |
| IFRA Transparency | IFRA | IFRA |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| SCIL (9/2019) | USEPA | Safer Chemical Ingredients List |
| Canada; pharmaceutical | DrugBank | DrugBank |
| consumer_product | P&G | Proctor & Gamble |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 14 of 14 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 37.6707981237727 | uM | AC50 | - | - | NTP_ICE_endocrine |
| 49.5166866717265 | uM | ACC | - | - | NTP_ICE_endocrine |
| =17.632 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 2V16EO95H1 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 2V16EO95H1 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 2V16EO95H1 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 2V16EO95H1 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| >10000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
| 0.00386 | unitless | Model Score | - | - | NTP_ICE_endocrine |
| 7500 | mg/kg bw/day | NOAEL | oral | mouse | COSMOS_DB |
| =0.09 | mM | NOEL | environmental | European Rabbit | ToxValDB_ECOTOX |
| =0.9 | mM | NOEL | environmental | European Rabbit | ToxValDB_ECOTOX |
| - | % | Positive reaction | Dermal | Human | NTP_ICE_skin_irritation |
Showing 14 of 14 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Palmitic acid | 200-312-9 | ECHA overview → |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
emollient
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
PALMITIC ACID
ChEMBL Phase
-1
Adverse Events
0
Bioactivity
11
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
ADI: No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Hexadecanoic acid?
Hexadecanoic acid appears on 19 regulatory/inventory lists including Canada; consumer_product; Substances in Products - Canada (4/2014), inert_ingredient; Pesticides, inert_ingredient; non_food_use; Pesticides, and 16 more. Source: EPA CPDat.
Is Hexadecanoic acid used in cosmetics?
Yes, Hexadecanoic acid is also indexed as a cosmetic ingredient under the name Palmitic Acid. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Hexadecanoic acid come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, ECHA REACH, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is Hexadecanoic acid used outside industrial chemicals?
Hexadecanoic acid also appears in cosmetics, pharmaceutical, food safety, cannabis databases.