What is the NOAEL for 4-(3-Ethoxy-4-hydroxyphenyl)-2-butanone?
4-(3-Ethoxy-4-hydroxyphenyl)-2-butanone has 4 NOAEL studies in the database. The lowest reported value is TH7XI54W45 UNII. Source: openFDA substances.
NOAEL Data
Cosmetic Ingredient
4-(3-Ethoxy-4-hydroxyphenyl)-2-butanone
CAS 569646-79-3
4-(3-Ethoxy-4-hydroxyphenyl)-2-butanone (CAS 569646-79-3) is a chemical substance. Key regulatory status: 1 regulatory/inventory list, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, SCCS.
View cosmetic safety profile for Hydroxyethoxyphenyl Butanone (HEPB / Ethylzingerone) →
Cross-Vertical Regulatory Divergence
4-(3-Ethoxy-4-hydroxyphenyl)-2-butanone is classified GHS Danger (H228, H302, H315, H319, H335, H412) in the chemicals database but is restricted in EU cosmetics at max 0.7%.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status/eu_max; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
4
SOURCE
chemical inventory jurisdictions
Regulatory lists
1
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
6 fields
Name
4-(3-Ethoxy-4-hydroxyphenyl)-2-butanone
CAS Number
569646-79-3
DTXSID
DTXSID101278928
Molecular Formula
C12H16O3
InChI Key
MXLOKFOWFPJWCW-UHFFFAOYSA-N
Monoisotopic Mass
208.109944375
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
1 records
Preservative
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
1 records
| List | Keyword | Source |
|---|---|---|
| Europe; Personal care | European Commission | CosIng |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 4 of 4 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| TH7XI54W45 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| TH7XI54W45 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| TH7XI54W45 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| TH7XI54W45 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
Showing 4 of 4 studies
SCCS Opinions
EU Scientific Committee opinions tied to the matched substance.
SOURCE
EU SCCS
2 opinions
| Opinion | Date | Conclusion | Max Conc. | Concerns |
|---|---|---|---|---|
| SCCS/1604/18 | 5 March 2019 | Safe with restrictions — safe at 0.7% in all assessed product types; eye irritation concern from Submission I resolved | 0.7% in all product types | Eye irritation (Draize test concern addressed in Submission II with additional data); not safe at 2% (requested in Submission I) |
| SCCS/1582/16 | 7 April 2017 | Safe with restrictions — safe at 0.7%; not safe at requested 2% | 0.7% | Eye irritation concern at higher concentrations (reason for Submission II); not safe at 2% as originally requested |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
restricted
Max
0.7%
Category
Preservative
Frequently Asked Questions
What regulatory lists include 4-(3-Ethoxy-4-hydroxyphenyl)-2-butanone?
4-(3-Ethoxy-4-hydroxyphenyl)-2-butanone appears on 1 regulatory/inventory list including Europe; Personal care. Source: EPA CPDat.
Is 4-(3-Ethoxy-4-hydroxyphenyl)-2-butanone used in cosmetics?
Yes, 4-(3-Ethoxy-4-hydroxyphenyl)-2-butanone is also indexed as a cosmetic ingredient under the name Hydroxyethoxyphenyl Butanone (HEPB / Ethylzingerone). View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 4-(3-Ethoxy-4-hydroxyphenyl)-2-butanone come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.
Does 4-(3-Ethoxy-4-hydroxyphenyl)-2-butanone have different safety status in cosmetics vs industrial chemicals?
4-(3-Ethoxy-4-hydroxyphenyl)-2-butanone is classified GHS Danger (H228, H302, H315, H319, H335, H412) in the chemicals database but is restricted in EU cosmetics at max 0.7%.
Is 4-(3-Ethoxy-4-hydroxyphenyl)-2-butanone used outside industrial chemicals?
4-(3-Ethoxy-4-hydroxyphenyl)-2-butanone also appears in cosmetics databases.