What is the NOAEL for 4-Methyl-1-(propan-2-yl)cyclohex-3-en-1-ol?
4-Methyl-1-(propan-2-yl)cyclohex-3-en-1-ol has 8 NOAEL studies in the database. The lowest reported value is L65MV77ZG6 UNII. Source: openFDA substances.
NOAEL Data
REACH Registered
Cosmetic Ingredient
4-Methyl-1-(propan-2-yl)cyclohex-3-en-1-ol
Also known as: 3-Cyclohexen-1-ol, 4-methyl-1-(1-methylethyl)-, (+)-Terpinen-4-ol, 4-06-00-00250, BRN 1906603, EINECS 209-235-5 (+14 more)
CAS 562-74-3
4-Methyl-1-(propan-2-yl)cyclohex-3-en-1-ol (CAS 562-74-3) is a chemical substance. Key regulatory status: REACH registered, 6 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
View cosmetic safety profile for 4-Terpineol (Terpinen-4-ol) →
SOURCE
NOAEL studies
NOAEL studies
8
SOURCE
Chemical inventory jurisdictions
Regulatory lists
6
SOURCE
EU CLP Annex VI
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
25 fields
Name
4-Methyl-1-(propan-2-yl)cyclohex-3-en-1-ol
CAS Number
562-74-3
DTXSID
DTXSID4044824
Molecular Formula
C10H18O
InChI Key
WRYLYDPHFGVWKC-UHFFFAOYSA-N
Monoisotopic Mass
154.135765
Synonyms
3-Cyclohexen-1-ol, 4-methyl-1-(1-methylethyl)-(+)-Terpinen-4-ol4-06-00-00250BRN 1906603EINECS 209-235-5EINECS 248-910-9FEMA No. 22481-para-Menthen-4-ol(+-)-p-Menth-1-en-4-olTerpinenolu-4UNII-L65MV77ZG61-Isopropyl-4-methyl-3-cyclohexen-1-ol
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
49 records
DeodorizerFlavouring and nutrientFragrance
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
6 records
| List | Keyword | Source |
|---|---|---|
| SCIL (9/2019) | USEPA | Safer Chemical Ingredients List |
| IFRA Transparency | IFRA | IFRA |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| consumer_product | P&G | Proctor & Gamble |
| Europe | European Commission | Fl@vis |
| Canada; pharmaceutical | DrugBank | DrugBank |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 8 of 8 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| L65MV77ZG6 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| L65MV77ZG6 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| L65MV77ZG6 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| L65MV77ZG6 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | % | Incidence of positive responses | Dermal | Human | NTP ICE skin sensitization |
| 3375 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP ICE skin sensitization |
| =250 | mg/kg bw/day | NOAEL | oral: gavage | Rat | EFSA |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP ICE skin sensitization |
Showing 8 of 8 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | p-menth-1-en-4-ol | 209-235-5 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
ChEMBL / DailyMed
TERPINEOL
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
2
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA
1 records
ADI: No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include 4-Methyl-1-(propan-2-yl)cyclohex-3-en-1-ol?
4-Methyl-1-(propan-2-yl)cyclohex-3-en-1-ol appears on 6 regulatory/inventory lists including SCIL (9/2019), IFRA Transparency, food_additive; Substances Added to Food (formerly EAFUS) (2/2019), and 3 more. Source: EPA CPDat.
Is 4-Methyl-1-(propan-2-yl)cyclohex-3-en-1-ol used in cosmetics?
Yes, 4-Methyl-1-(propan-2-yl)cyclohex-3-en-1-ol is also indexed as a cosmetic ingredient under the name 4-Terpineol (Terpinen-4-ol). View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 4-Methyl-1-(propan-2-yl)cyclohex-3-en-1-ol come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is 4-Methyl-1-(propan-2-yl)cyclohex-3-en-1-ol used outside industrial chemicals?
4-Methyl-1-(propan-2-yl)cyclohex-3-en-1-ol also appears in cosmetics, pharmaceutical, food safety, cannabis databases.