What is the NOAEL for L-Cystine?
L-Cystine has 18 NOAEL studies in the database. The lowest reported value is 48TCX9A1VT UNII. Source: openFDA substances.
NOAEL Data
REACH Registered
Cosmetic Ingredient
L-Cystine
Also known as: 4-04-00-03155, Alanine, 3,3'-dithiodi-, Bis(beta-amino-beta-carboxyethyl)disulfide, BRN 1728094, Cystine (L)- (+14 more)
CAS 56-89-3
L-Cystine (CAS 56-89-3) is a chemical substance. Key regulatory status: REACH registered, 2 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, ECHA REACH.
SOURCE
noael studies public
NOAEL studies
18
SOURCE
chemical inventory jurisdictions
Regulatory lists
2
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
25 fields
Name
L-Cystine
CAS Number
56-89-3
DTXSID
DTXSID2046418
Molecular Formula
C6H12N2O4S2
InChI Key
LEVWYRKDKASIDU-IMJSIDKUSA-N
Monoisotopic Mass
240.023849
Synonyms
4-04-00-03155Alanine, 3,3'-dithiodi-Bis(beta-amino-beta-carboxyethyl)disulfideBRN 1728094Cystine (L)-beta,beta'-Diamino-beta,beta'-dicarboxydiethyldisulfidebeta,beta'-Dithioalanine, L-(R-(R*,R*))-3,3'-Dithiobis(2-aminopropanoic acid)3,3'-Dithiobis(2-aminopropanoic acid), (R-(R*,R*))-EINECS 200-296-3Propanoic acid, 3,3'-dithiobis(2-amino-, (R-(R*,R*))-UNII-48TCX9A1VT
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
9 records
Anti-static agentDeodorizerSoftener and conditionerFlavouring and nutrientFiller
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
2 records
| List | Keyword | Source |
|---|---|---|
| Europe | European Commission | Fl@vis |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 18 of 18 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 48TCX9A1VT | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 48TCX9A1VT | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 48TCX9A1VT | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 48TCX9A1VT | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| >25000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| 500 | mg/kg bw/day | NOAEL | oral | rabbit | COSMOS_DB |
| ~600 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| 1500 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 1792 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 1875 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 1958 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 2000 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 2083 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 2500 | mg/kg bw/day | NOAEL | oral | cat | COSMOS_DB |
| 3500 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 5000 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 5230 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 6000 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
Showing 18 of 18 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Cystine | 200-296-3 | ECHA overview → |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
amino_acid
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CYSTINE
ChEMBL Phase
2
Adverse Events
0
Bioactivity
2
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
1 food-safety record found.
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include L-Cystine?
L-Cystine appears on 2 regulatory/inventory lists including Europe, food_additive; Substances Added to Food (formerly EAFUS) (2/2019). Source: EPA CPDat.
Is L-Cystine used in cosmetics?
Yes, L-Cystine is also indexed as a cosmetic ingredient under the name Cystine. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for L-Cystine come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is L-Cystine used outside industrial chemicals?
L-Cystine also appears in cosmetics, pharmaceutical, food safety, cannabis databases.