NOAEL Data REACH Registered Cosmetic Ingredient

Phenol, 4,4'-(1-methylethylidene)bis-, polymer with 2-(chloromethyl)oxirane, 2-propenoate

CAS 55818-57-0

Phenol, 4,4'-(1-methylethylidene)bis-, polymer with 2-(chloromethyl)oxirane, 2-propenoate (CAS 55818-57-0) is a chemical substance. Key regulatory status: REACH registered, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.

View cosmetic safety profile for 4,4'-Isopropylidenediphenyl/Epichlorohydrin Copolymer Diacrylate →

SOURCE noael studies public
NOAEL studies
3
SOURCE chemical inventory jurisdictions
Regulatory lists
0
SOURCE eu clp annex vi
GHS signal
Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 3 fields
Name
Phenol, 4,4'-(1-methylethylidene)bis-, polymer with 2-(chloromethyl)oxirane, 2-propenoate
CAS Number
55818-57-0
DTXSID
DTXSID501011994

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 31 records
Film formerHardenerCatalyst

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 3 of 3 studies
ValueUnitEndpointRouteSpeciesSource
=1.17mg/m3DNEL systemicinhalationHumanToxValDB_GESTIS_DNEL
=1000mg/kg bw/dayLOAELoralRatToxValDB_EPA_TSCA_8e
<100mg/kg bw/dayNOAELoralRatToxValDB_EPA_TSCA_8e

Showing 3 of 3 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records
StatusNameEC NumberLink
Registered4,4'-Isopropylidenediphenol, oligomeric reaction products with 1-chloro-2,3-epoxypropane, esters with acrylic acid500-130-2ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records
Inventory Status
listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
prohibited
Max
-
Category
Rheology Modifier
View full cosmetic safety profile →

Frequently Asked Questions

What is the NOAEL for Phenol, 4,4'-(1-methylethylidene)bis-, polymer with 2-(chloromethyl)oxirane, 2-propenoate?

Phenol, 4,4'-(1-methylethylidene)bis-, polymer with 2-(chloromethyl)oxirane, 2-propenoate has 3 NOAEL studies in the database. The lowest reported value is 1.17 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.

Is Phenol, 4,4'-(1-methylethylidene)bis-, polymer with 2-(chloromethyl)oxirane, 2-propenoate used in cosmetics?

Yes, Phenol, 4,4'-(1-methylethylidene)bis-, polymer with 2-(chloromethyl)oxirane, 2-propenoate is also indexed as a cosmetic ingredient under the name 4,4'-Isopropylidenediphenyl/Epichlorohydrin Copolymer Diacrylate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Phenol, 4,4'-(1-methylethylidene)bis-, polymer with 2-(chloromethyl)oxirane, 2-propenoate come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.

Does Phenol, 4,4'-(1-methylethylidene)bis-, polymer with 2-(chloromethyl)oxirane, 2-propenoate have different safety status in cosmetics vs industrial chemicals?

Phenol, 4,4'-(1-methylethylidene)bis-, polymer with 2-(chloromethyl)oxirane, 2-propenoate is prohibited in EU cosmetics but has active industrial GHS classifications (H317, H319).

Is Phenol, 4,4'-(1-methylethylidene)bis-, polymer with 2-(chloromethyl)oxirane, 2-propenoate used outside industrial chemicals?

Phenol, 4,4'-(1-methylethylidene)bis-, polymer with 2-(chloromethyl)oxirane, 2-propenoate also appears in cosmetics databases.