NOAEL Data REACH Registered Cosmetic Ingredient

Acesulfame potassium

Also known as: 6-Methyl-1,2,3-oxathiazin-4(3h)-one 2,2-dioxide potassium salt, Potassium 3,4-dihydro-6-methyl-1,2,3-oxathiazine-4-one-2,2-dioxide, Potassium acesulfame, Acesulfam-K, EINECS 259-715-3 (+1 more)

CAS 55589-62-3

Acesulfame potassium (CAS 55589-62-3) is a chemical substance. Key regulatory status: REACH registered, 2 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.

View cosmetic safety profile for Potassium Acesulfame →

SOURCE noael studies public
NOAEL studies
42
SOURCE chemical inventory jurisdictions
Regulatory lists
2
SOURCE eu clp annex vi
GHS signal
Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 12 fields
Name
Acesulfame potassium
CAS Number
55589-62-3
DTXSID
DTXSID1030606
Molecular Formula
C4H5NO4S.K
InChI Key
WBZFUFAFFUEMEI-UHFFFAOYSA-M
Monoisotopic Mass
201.957635
Synonyms
6-Methyl-1,2,3-oxathiazin-4(3h)-one 2,2-dioxide potassium saltPotassium 3,4-dihydro-6-methyl-1,2,3-oxathiazine-4-one-2,2-dioxidePotassium acesulfameAcesulfam-KEINECS 259-715-3Acesulfame-potassium

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 15 records
DeodorizerFlavouring and nutrient

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 2 records
ListKeywordSource
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)FDAUnited States Food and Drug Administration (FDA)
inert_ingredient; non_food_use; PesticidesEPACPCat

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 42 of 42 studies
ValueUnitEndpointRouteSpeciesSource
=9mg/kg bw/dayADI-ConsumersEFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx
=9mg/kg bw/dayADI-ConsumersEFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx
=450mg/m3DNEL systemicinhalationHumanToxValDB_GESTIS_DNEL
23OV73Q5G9UNIIFDA UNII substance identifier--openFDA substances
23OV73Q5G9UNIIFDA UNII substance identifier--openFDA substances
23OV73Q5G9UNIIFDA UNII substance identifier--openFDA substances
23OV73Q5G9UNIIFDA UNII substance identifier--openFDA substances
=5438mg/kg bwLD50oralRatNTP_ICE_acute_oral
=5565mg/kg bwLD50oralRatNTP_ICE_acute_oral
=7431mg/kg bwLD50oralRatNTP_ICE_acute_oral
=10175mg/kg bwLD50oralRatNTP_ICE_acute_oral
10000mg/kg bw/dayLOAELoralratCOSMOS_DB
-unitlessModel Score--NTP_ICE_endocrine
300mg/kg bw/dayNOAELoralratCOSMOS_DB
>600mg/kg bw/dayNOAELoralDogToxValDB_ECHA_IUCLID
750mg/kg bw/dayNOAELoraldogCOSMOS_DB
900mg/kg bw/dayNOAELoralrabbitCOSMOS_DB
1500mg/kg bw/dayNOAELoralratCOSMOS_DB
>1850mg/kg bw/dayNOAELoralMouseToxValDB_ECHA_IUCLID
>2340mg/kg bw/dayNOAELoralRatToxValDB_ECHA_IUCLID
>=2880mg/kg bw/dayNOAELoralRatToxValDB_ECHA_IUCLID
3000mg/kg bw/dayNOAELoralratCOSMOS_DB
4500mg/kg bw/dayNOAELoralmouseCOSMOS_DB
4700mg/kg bw/dayNOAELoralmouseCOSMOS_DB
5543mg/kg bw/dayNOAELoralratCOSMOS_DB
>5550mg/kg bw/dayNOAELoralMouseToxValDB_ECHA_IUCLID
5571mg/kg bw/dayNOAELoralratCOSMOS_DB
5652mg/kg bw/dayNOAELoralratCOSMOS_DB
5673mg/kg bw/dayNOAELoralratCOSMOS_DB
5691mg/kg bw/dayNOAELoralratCOSMOS_DB
5863mg/kg bw/dayNOAELoralratCOSMOS_DB
6922mg/kg bw/dayNOAELoralratCOSMOS_DB
7072mg/kg bw/dayNOAELoralratCOSMOS_DB
7078mg/kg bw/dayNOAELoralratCOSMOS_DB
7222mg/kg bw/dayNOAELoralratCOSMOS_DB
7983mg/kg bw/dayNOAELoralratCOSMOS_DB
8251mg/kg bw/dayNOAELoralratCOSMOS_DB
10000mg/kg bw/dayNOAELoralratCOSMOS_DB
=10000ppmNOAELoralRatToxValDB_ECHA_IUCLID
>30000ppmNOAELoralRatToxValDB_ECHA_IUCLID
=900mg/kg bw/dayNOELoralRabbitToxValDB_ECHA_IUCLID
=2000mg/kg bw/dayNOELoralMouseToxValDB_ECOTOX

Showing 42 of 42 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records
StatusNameEC NumberLink
Registered6-methyl-1,2,3-oxathiazin-4(3H)-one 2,2-dioxide, potassium salt259-715-3ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records
Inventory Status
listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
View full cosmetic safety profile →

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL ACESULFAME POTASSIUM
ChEMBL Phase
3
Adverse Events
0
Bioactivity
2
View full pharmaceutical profile →

Food Safety Data

Same-CAS food additive, ADI, and GRAS records where available.

SOURCE EFSA / FDA GRAS 1 records

E950 — ADI: 15 mg/kg bw

View full food safety profile →

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the NOAEL for Acesulfame potassium?

Acesulfame potassium has 42 NOAEL studies in the database. The lowest reported value is 9 mg/kg bw/day in Consumers. Source: EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx.

What regulatory lists include Acesulfame potassium?

Acesulfame potassium appears on 2 regulatory/inventory lists including food_additive; Substances Added to Food (formerly EAFUS) (2/2019), inert_ingredient; non_food_use; Pesticides. Source: EPA CPDat.

Is Acesulfame potassium used in cosmetics?

Yes, Acesulfame potassium is also indexed as a cosmetic ingredient under the name Potassium Acesulfame. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Acesulfame potassium come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Is Acesulfame potassium used outside industrial chemicals?

Acesulfame potassium also appears in cosmetics, pharmaceutical, food safety, cannabis databases.