What is the GHS hazard classification for Methyl propanoate?
Methyl propanoate (CAS 554-12-1) is classified under EU CLP Annex VI as Flam. Liq. 2; Acute Tox. 4 * with signal word Danger. Hazard statements: H225; H332. Source: EU CLP Annex VI (ECHA).
Danger
GHS02GHS07
NOAEL Data
REACH Registered
Cosmetic Ingredient
Methyl propanoate
Also known as: Propanoic acid, methyl ester, 4-02-00-00704, BRN 1737628, EINECS 209-060-4, FEMA No. 2742 (+5 more)
CAS 554-12-1
Methyl propanoate (CAS 554-12-1) is a chemical substance with GHS signal word Danger; key hazard signal: H225; H332. Key regulatory status: REACH registered, 5 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC.
Cross-Vertical Regulatory Divergence
Methyl propanoate is classified GHS Danger (H225, H332) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: eu_clp_annex_vi.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
11
SOURCE
chemical inventory jurisdictions
Regulatory lists
5
SOURCE
eu clp annex vi
GHS signal
Danger
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
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DSSTox identifiers
16 fields
Name
Methyl propanoate
CAS Number
554-12-1
DTXSID
DTXSID7027201
Molecular Formula
C4H8O2
InChI Key
RJUFJBKOKNCXHH-UHFFFAOYSA-N
Monoisotopic Mass
88.052429
Synonyms
Propanoic acid, methyl ester4-02-00-00704BRN 1737628EINECS 209-060-4FEMA No. 2742FEMA Number 2742Methylester kyseliny propionoveUNII-NB21C0D33WFEMA 2742Methyl ester of propanoic acid
GHS / CLP Classification
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
SOURCE
EU CLP Annex VI (ECHA)
1 classifications
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Flam. Liq. 2; Acute Tox. 4 * | H225; H332 | GHS02; GHS07 | Danger |
ICSC Chemical Safety
International Chemical Safety Card hazard and exposure summary.
SOURCE
ILO/WHO International Chemical Safety Cards
1 records
| Field | Value |
|---|---|
| Short-term Effects | The substance is irritating to the respiratory tract, skin and eyes. |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
4 records
FragranceFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
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EPA CPDat
5 records
| List | Keyword | Source |
|---|---|---|
| air; detected; emissions; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
| IFRA Transparency | IFRA | IFRA |
| Europe | European Commission | Fl@vis |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| air; detected; emissions; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 11 of 11 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| NB21C0D33W | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| NB21C0D33W | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| NB21C0D33W | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| NB21C0D33W | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 1350 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| =5000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =500 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_EFSA |
| =500 | mg/kg bw/day | NOAEL | oral: gavage | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| =500 | mg/kg bw/day | NOAEL | oral: gavage | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
Showing 11 of 11 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Methyl propionate | 209-060-4 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
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AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
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CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL3183973
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What is the NOAEL for Methyl propanoate?
Methyl propanoate has 11 NOAEL studies in the database. The lowest reported value is NB21C0D33W UNII. Source: openFDA substances.
What regulatory lists include Methyl propanoate?
Methyl propanoate appears on 4 regulatory/inventory lists including air; detected; emissions; Europe; Toys and children's products, IFRA Transparency, Europe, and 1 more. Source: EPA CPDat.
Is Methyl propanoate used in cosmetics?
Yes, Methyl propanoate is also indexed as a cosmetic ingredient under the name Methyl Propionate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Methyl propanoate come from?
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Does Methyl propanoate have different safety status in cosmetics vs industrial chemicals?
Methyl propanoate is classified GHS Danger (H225, H332) in the chemicals database but is allowed in EU cosmetics.
Is Methyl propanoate used outside industrial chemicals?
Methyl propanoate also appears in cosmetics, pharmaceutical, cannabis databases.