Also known as: 1,2,4-Benzenetricarboxylic anhydride, 5-Isobenzofurancarboxylic acid, 1,3-dihydro-1,3-dioxo-, 5-18-08-00562, Anhydride-ethomid ht polymer, BRN 0009394 (+13 more)
CAS 552-30-7
Trimellitic anhydride (CAS 552-30-7) is a chemical substance with GHS signal word Danger; key hazard signal: H335; H318; H334; H317. Key regulatory status: SVHC Candidate List, REACH registered, 3 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ECHA SVHC, ILO ICSC, OSHA.
Trimellitic anhydride is classified GHS Danger (H335, H318, H334, H317) in the chemicals database but is allowed in EU cosmetics.
CAS, identifiers, formula, and alternate names for the matched substance record.
Candidate List status and reason under the ECHA REACH SVHC program.
| Substance | Reason | Included |
|---|---|---|
| Benzene-1,2,4-tricarboxylic acid 1,2 anhydride | Respiratory sensitising properties (Article 57(f) - human health) | 27-Jun-2018 |
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| STOT SE 3; Eye Dam. 1; Resp. Sens. 1; Skin Sens. 1 | H335; H318; H334; H317 | GHS07; GHS05; GHS08 | Danger |
International Chemical Safety Card hazard and exposure summary.
| Field | Value |
|---|---|
| Short-term Effects | The substance is severely irritating to the eyes. The substance is irritating to the skin and respiratory tract. Inhalation of dust may cause asthma-like reactions. |
| Long-term Effects | Repeated or prolonged inhalation may cause asthma. The substance may cause allergic reactions with flu-like symptoms and 'pulmonary disease-anaemia syndrome'. |
| Routes of Exposure | The substance can be absorbed into the body by inhalation and by ingestion. |
Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.
| Agency | Metric | Value | ppm | mg/m3 | Skin |
|---|---|---|---|---|---|
| NIOSH | TWA | 0.005 ppm (0.04 mg/m³) | 0.005 | 0.04 | N |
| ACGIH | TWA | 0.0005 mg/m³ (inhalable fraction and vapor) [2007] | - | 0.0005 | Y |
| ACGIH | STEL | 0.002 mg/m³ (inhalable fraction and vapor) [2007] | - | 0.002 | Y |
| CAL/OSHA | CEILING | 0.005 ppm (0.04 mg/m³) | 0.005 | 0.04 | N |
Industrial and product-use categories associated with this substance.
Inventory, screening, and regulatory list matches from public chemical databases.
| List | Keyword | Source |
|---|---|---|
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| CEDI | FDA | United States Food and Drug Administration (FDA) |
| Indirect additives food contact (10/2018) | FDA | United States Food and Drug Administration (FDA) |
Toxicology endpoints rendered from public NOAEL study rows.
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 81.2 | ug/mL | CD86, EC150 | Dermal | - | NTP_ICE_skin_sensitization |
| >1344.882 | ug/mL | CD86, EC150 | Dermal | - | NTP_ICE_skin_sensitization |
| 250 | ug/mL | CV75 | Dermal | - | NTP_ICE_skin_sensitization |
| =17.5 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| -1.1 | % | Depletion Cys | Dermal | - | NTP_ICE_skin_sensitization |
| 43.7 | % | Depletion Lys | Dermal | - | NTP_ICE_skin_sensitization |
| 21.85 | % | Depletion Lys + Cys | Dermal | - | NTP_ICE_skin_sensitization |
| >2000 | uM | EC1.5 | Dermal | - | NTP_ICE_skin_sensitization |
| 0.11 | % | EC3 | Dermal | Mouse | NTP_ICE_skin_sensitization |
| 0.19 | % | EC3 | Dermal | Mouse | NTP_ICE_skin_sensitization |
| 9.2 | % | EC3 | Dermal | Mouse | NTP_ICE_skin_sensitization |
| 80T61EUU7H | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 80T61EUU7H | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 80T61EUU7H | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 80T61EUU7H | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 1.1 | ratio | Imax | Dermal | - | NTP_ICE_skin_sensitization |
| >2.33 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| =1 | % | LOEL | dermal | Mouse | ToxValDB_ECOTOX |
| =3 | % | LOEL | dermal | Mouse | ToxValDB_ECOTOX |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
| =0.1 | % | NOEL | dermal | Mouse | ToxValDB_ECOTOX |
| =0.3 | % | NOEL | dermal | Mouse | ToxValDB_ECOTOX |
Showing 22 of 22 studies
Registration status from the ECHA REACH registered substances database.
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Benzene-1,2,4-tricarboxylic acid 1,2-anhydride | 209-008-0 | ECHA overview → |
Australian industrial chemicals inventory status and applicable conditions.
Same-CAS cosmetic ingredient record for cross-vertical context.
Same-CAS pharmaceutical records from drug and bioactivity sources.
Same-CAS cannabis compliance and lab records where available.
1 cannabis record found in efsa substances.
View full cannabis profile →Trimellitic anhydride (CAS 552-30-7) is classified under EU CLP Annex VI as STOT SE 3; Eye Dam. 1; Resp. Sens. 1; Skin Sens. 1 with signal word Danger. Hazard statements: H335; H318; H334; H317. Source: EU CLP Annex VI (ECHA).
Trimellitic anhydride has 22 NOAEL studies in the database. The lowest reported value is -1.1 % via Dermal. Source: NTP_ICE_skin_sensitization.
Trimellitic anhydride appears on 3 regulatory/inventory lists including inert_ingredient; non_food_use; Pesticides, CEDI, Indirect additives food contact (10/2018). Source: EPA CPDat.
Yes, Trimellitic anhydride is listed on the ECHA REACH Candidate List as a Substance of Very High Concern. Reason: Respiratory sensitising properties (Article 57(f) - human health). Source: ECHA SVHC Candidate List.
Occupational exposure limits for Trimellitic anhydride are set by NIOSH, ACGIH, CAL/OSHA. 4 limit values from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.
Yes, Trimellitic anhydride is also indexed as a cosmetic ingredient under the name TRIMELLITIC ANHYDRIDE. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ECHA SVHC Candidate List, ILO/WHO ICSC, OSHA/NIOSH/ACGIH, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Trimellitic anhydride is classified GHS Danger (H335, H318, H334, H317) in the chemicals database but is allowed in EU cosmetics.
Trimellitic anhydride also appears in cosmetics, pharmaceutical, cannabis databases.