What is the NOAEL for Chlorhexidine?
Chlorhexidine has 14 NOAEL studies in the database. The lowest reported value is R4KO0DY52L UNII. Source: openFDA substances.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Chlorhexidine
Also known as: 2,4,11,13-Tetraazatetradecanediimidamide, N,N''-bis(4-chlorophenyl)-3,12-diimino-, 2,4,11,13-Tetraazatetradecanediimidamide, N1,N14-bis(4-chlorophenyl)-3,12-diimino-, N1,N14-bis(4-chlorophenyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediimidamide, 4-12-00-01201, 1,6-Bis(5-(p-chlorophenyl)biguandino)hexane (+14 more)
CAS 55-56-1
Chlorhexidine (CAS 55-56-1) is a chemical substance. Key regulatory status: REACH registered, 5 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, ECHA REACH.
Cross-Vertical Regulatory Divergence
Chlorhexidine is classified GHS Danger (H302, H315, H318, H319, H334, H335, H373, H400) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
14
SOURCE
chemical inventory jurisdictions
Regulatory lists
5
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
25 fields
Name
Chlorhexidine
CAS Number
55-56-1
DTXSID
DTXSID2033314
Molecular Formula
C22H30Cl2N10
InChI Key
GHXZTYHSJHQHIJ-UHFFFAOYSA-N
Monoisotopic Mass
504.203196
Synonyms
2,4,11,13-Tetraazatetradecanediimidamide, N,N''-bis(4-chlorophenyl)-3,12-diimino-2,4,11,13-Tetraazatetradecanediimidamide, N1,N14-bis(4-chlorophenyl)-3,12-diimino-N1,N14-bis(4-chlorophenyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediimidamide4-12-00-012011,6-Bis(5-(p-chlorophenyl)biguandino)hexane1,6-Bis(p-chlorophenyldiguanido)hexaneBRN 28264321,6-Di(4'-chlorophenyldiguanido)hexaneEINECS 200-238-71,1'-Hexamethylenebis(5-(p-chlorophenyl)biguanide)ChlorhexidinumCloresidina
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
9 records
BiocidePreservative
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
5 records
| List | Keyword | Source |
|---|---|---|
| Canada; consumer_product; Substances in Products - Canada (4/2014) | Government of Canada | CPCat |
| pharmaceutical | US International Trade Commission | CPCat |
| active_ingredient; animal_products; Europe; pharmaceutical; residue | EU | CPCat |
| Europe; pharmaceutical | Drinking Water Inspectorate | CPCat |
| Canada; pharmaceutical | DrugBank | DrugBank |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 14 of 14 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| R4KO0DY52L | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| R4KO0DY52L | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| R4KO0DY52L | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| R4KO0DY52L | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 1 | unitless | GHS Classification | Ocular | Rabbit | NTP_ICE_eye_irritation |
| =1180 | mg/kg bw | LD50 | oral | Rat (Female) | NTP_ICE_acute_oral |
| >1430 | mg/kg bw | LD50 | oral | Rat (Male) | NTP_ICE_acute_oral |
| =1710 | mg/kg bw | LD50 | oral | Rat (Male) | NTP_ICE_acute_oral |
| >1870 | mg/kg bw | LD50 | oral | Rat (Female) | NTP_ICE_acute_oral |
| =2292 | mg/kg bw | LD50 | oral | Rat (Male) | NTP_ICE_acute_oral |
| =3055 | mg/kg bw | LD50 | oral | Rat (Female) | NTP_ICE_acute_oral |
| <3180 | mg/kg bw | LD50 | oral | Rat (Male) | NTP_ICE_acute_oral |
| <4239 | mg/kg bw | LD50 | oral | Rat (Female) | NTP_ICE_acute_oral |
| =5000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
Showing 14 of 14 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Chlorhexidine | 200-238-7 | ECHA overview → |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
preservative
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHLORHEXIDINE
ChEMBL Phase
4
Adverse Events
3208
Bioactivity
18
Frequently Asked Questions
What regulatory lists include Chlorhexidine?
Chlorhexidine appears on 5 regulatory/inventory lists including Canada; consumer_product; Substances in Products - Canada (4/2014), pharmaceutical, active_ingredient; animal_products; Europe; pharmaceutical; residue, and 2 more. Source: EPA CPDat.
Is Chlorhexidine used in cosmetics?
Yes, Chlorhexidine is also indexed as a cosmetic ingredient under the name Chlorhexidine. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Chlorhexidine come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Does Chlorhexidine have different safety status in cosmetics vs industrial chemicals?
Chlorhexidine is classified GHS Danger (H302, H315, H318, H319, H334, H335, H373, H400) in the chemicals database but is allowed in EU cosmetics.
Is Chlorhexidine used outside industrial chemicals?
Chlorhexidine also appears in cosmetics, pharmaceutical databases.