What is the NOAEL for 1,4-Dioxacyclohexadecane-5,16-dione?
1,4-Dioxacyclohexadecane-5,16-dione has 9 NOAEL studies in the database. The lowest reported value is 176 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
1,4-Dioxacyclohexadecane-5,16-dione
Also known as: 4-19-00-01935, BRN 0199405, Cyclic ethylene dodecanedioate, EINECS 259-423-6, Ethylene cyclic dodecanedioate (+3 more)
CAS 54982-83-1
1,4-Dioxacyclohexadecane-5,16-dione (CAS 54982-83-1) is a chemical substance. Key regulatory status: REACH registered, 3 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
SOURCE
noael studies public
NOAEL studies
9
SOURCE
chemical inventory jurisdictions
Regulatory lists
3
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
14 fields
Name
1,4-Dioxacyclohexadecane-5,16-dione
CAS Number
54982-83-1
DTXSID
DTXSID1044568
Molecular Formula
C14H24O4
InChI Key
GJJSUPSPZIZYPM-UHFFFAOYSA-N
Monoisotopic Mass
256.167459
Synonyms
4-19-00-01935BRN 0199405Cyclic ethylene dodecanedioateEINECS 259-423-6Ethylene cyclic dodecanedioateEthylenedodecanedioateMuskonateUNII-NBW53A4P49
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
17 records
FragranceDeodorizer
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
3 records
| List | Keyword | Source |
|---|---|---|
| IFRA Transparency | IFRA | IFRA |
| consumer_product | P&G | Proctor & Gamble |
| SCIL (9/2019) | USEPA | Safer Chemical Ingredients List |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 9 of 9 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =176 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| NBW53A4P49 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| NBW53A4P49 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| NBW53A4P49 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| NBW53A4P49 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 12400 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| 13500 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
Showing 9 of 9 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 1,4-dioxacyclohexadecane-5,16-dione | 259-423-6 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL3186723
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Frequently Asked Questions
What regulatory lists include 1,4-Dioxacyclohexadecane-5,16-dione?
1,4-Dioxacyclohexadecane-5,16-dione appears on 3 regulatory/inventory lists including IFRA Transparency, consumer_product, SCIL (9/2019). Source: EPA CPDat.
Is 1,4-Dioxacyclohexadecane-5,16-dione used in cosmetics?
Yes, 1,4-Dioxacyclohexadecane-5,16-dione is also indexed as a cosmetic ingredient under the name Ethylene Dodecanedioate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 1,4-Dioxacyclohexadecane-5,16-dione come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Is 1,4-Dioxacyclohexadecane-5,16-dione used outside industrial chemicals?
1,4-Dioxacyclohexadecane-5,16-dione also appears in cosmetics, pharmaceutical databases.