What is the NOAEL for N-(2-Hydroxyethyl)palmitamide?
N-(2-Hydroxyethyl)palmitamide has 7 NOAEL studies in the database. The lowest reported value is 49.3 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
N-(2-Hydroxyethyl)palmitamide
Also known as: Palmitoylethanolamide, Hexadecanamide, N-(2-hydroxyethyl)-, EINECS 208-867-9, NSC 23320, Palmidrolum (+14 more)
CAS 544-31-0
N-(2-Hydroxyethyl)palmitamide (CAS 544-31-0) is a chemical substance. Key regulatory status: REACH registered, 4 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, ECHA REACH.
View cosmetic safety profile for Palmitoylethanolamide (PEA) →
Cross-Vertical Regulatory Divergence
N-(2-Hydroxyethyl)palmitamide is classified GHS Danger (H315, H318, H411, H412) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
7
SOURCE
chemical inventory jurisdictions
Regulatory lists
4
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
25 fields
Name
N-(2-Hydroxyethyl)palmitamide
CAS Number
544-31-0
DTXSID
DTXSID4042254
Molecular Formula
C18H37NO2
InChI Key
HXYVTAGFYLMHSO-UHFFFAOYSA-N
Monoisotopic Mass
299.282429
Synonyms
PalmitoylethanolamideHexadecanamide, N-(2-hydroxyethyl)-EINECS 208-867-9NSC 23320PalmidrolumUNII-6R8T1UDM3VAnandamide (16:0)HydroxyethylpalmitamideLoramine P 256Monoethanolamine palmitic acid amideN-(2-Hydroxyethyl)hexadecanamideN-Hexadecyl-ethanolamine
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
3 records
Anti-static agentViscosity modifierFoamant
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
4 records
| List | Keyword | Source |
|---|---|---|
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| pharmaceutical | US International Trade Commission | CPCat |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Canada; pharmaceutical | DrugBank | DrugBank |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 7 of 7 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =49.3 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 6R8T1UDM3V | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 6R8T1UDM3V | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 6R8T1UDM3V | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 6R8T1UDM3V | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =1000 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =1000 | mg/kg bw/day | NOEL | oral | Rat | ToxValDB_ECHA_IUCLID |
Showing 7 of 7 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Palmidrol | 208-867-9 | ECHA overview → |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
emollient
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
PALMIDROL
ChEMBL Phase
3
Adverse Events
45
Bioactivity
11
Frequently Asked Questions
What regulatory lists include N-(2-Hydroxyethyl)palmitamide?
N-(2-Hydroxyethyl)palmitamide appears on 3 regulatory/inventory lists including inert_ingredient; non_food_use; Pesticides, pharmaceutical, Canada; pharmaceutical. Source: EPA CPDat.
Is N-(2-Hydroxyethyl)palmitamide used in cosmetics?
Yes, N-(2-Hydroxyethyl)palmitamide is also indexed as a cosmetic ingredient under the name Palmitoylethanolamide (PEA). View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for N-(2-Hydroxyethyl)palmitamide come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Does N-(2-Hydroxyethyl)palmitamide have different safety status in cosmetics vs industrial chemicals?
N-(2-Hydroxyethyl)palmitamide is classified GHS Danger (H315, H318, H411, H412) in the chemicals database but is allowed in EU cosmetics.
Is N-(2-Hydroxyethyl)palmitamide used outside industrial chemicals?
N-(2-Hydroxyethyl)palmitamide also appears in cosmetics, pharmaceutical databases.