What is the NOAEL for C.I. Basic Yellow 28?
C.I. Basic Yellow 28 has 10 NOAEL studies in the database. The lowest reported value is 1.12 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
C.I. Basic Yellow 28
Also known as: 3H-Indolium, 2-[[2-(4-methoxyphenyl)-2-methylhydrazinylidene]methyl]-1,3,3-trimethyl-, methyl sulfate (1:1), 3H-Indolium, 2-[[(4-methoxyphenyl)methylhydrazono]methyl]-1,3,3-trimethyl-, methyl sulfate, EC No.: 258-946-7, Astrazon Golden Yellow GL, Astrazon Golden Yellow GL-E (+15 more)
CAS 54060-92-3
C.I. Basic Yellow 28 (CAS 54060-92-3) is a chemical substance. Key regulatory status: REACH registered, 3 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
Cross-Vertical Regulatory Divergence
C.I. Basic Yellow 28 is prohibited in EU cosmetics but has active industrial GHS classifications (H301, H302, H312, H318, H330, H400, H410).
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
10
SOURCE
chemical inventory jurisdictions
Regulatory lists
3
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
26 fields
Name
C.I. Basic Yellow 28
CAS Number
54060-92-3
DTXSID
DTXSID20879816
Molecular Formula
C20H24N3O.CH4O4S
InChI Key
SPWPAFQLIZTXFN-UHFFFAOYSA-M
Monoisotopic Mass
434.174967
Synonyms
3H-Indolium, 2-[[2-(4-methoxyphenyl)-2-methylhydrazinylidene]methyl]-1,3,3-trimethyl-, methyl sulfate (1:1)3H-Indolium, 2-[[(4-methoxyphenyl)methylhydrazono]methyl]-1,3,3-trimethyl-, methyl sulfateEC No.: 258-946-7Astrazon Golden Yellow GLAstrazon Golden Yellow GL-EAstrazon Golden Yellow GL-E 200Astrazon Golden Yellow GL-FWBasacryl Golden Yellow FD-X-GFLBasacryl Golden Yellow X-GFLBasic Yellow 28Cationic Gold YellowCationic Golden Yellow SD-GL
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
2 records
Dye
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
3 records
| List | Keyword | Source |
|---|---|---|
| banned; Europe; Personal care | European Commission | CosIng |
| Europe; Personal care - hair coloring | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care - hair coloring | Danish Environmental Protection Agency | Danish EPA |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 10 of 10 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =1.12 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 2HJO358I4S | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 2HJO358I4S | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 2HJO358I4S | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 2HJO358I4S | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0.076 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| 0.29 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| 0.474 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| =95 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =300 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
Showing 10 of 10 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 2-[[(4-methoxyphenyl)methylhydrazono]methyl]-1,3,3-trimethyl-3H-indolium methyl sulphate | 258-946-7 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
prohibited
Max
-
Category
Colorant
Frequently Asked Questions
What regulatory lists include C.I. Basic Yellow 28?
C.I. Basic Yellow 28 appears on 2 regulatory/inventory lists including banned; Europe; Personal care, Europe; Personal care - hair coloring. Source: EPA CPDat.
Is C.I. Basic Yellow 28 used in cosmetics?
Yes, C.I. Basic Yellow 28 is also indexed as a cosmetic ingredient under the name Basic Yellow 28. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for C.I. Basic Yellow 28 come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.
Does C.I. Basic Yellow 28 have different safety status in cosmetics vs industrial chemicals?
C.I. Basic Yellow 28 is prohibited in EU cosmetics but has active industrial GHS classifications (H301, H302, H312, H318, H330, H400, H410).
Is C.I. Basic Yellow 28 used outside industrial chemicals?
C.I. Basic Yellow 28 also appears in cosmetics databases.