What is the NOAEL for Dodecamethylcyclohexasiloxane?
Dodecamethylcyclohexasiloxane has 8 NOAEL studies in the database. The lowest reported value is 1.22 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
SVHC
REACH Registered
Cosmetic Ingredient
Dodecamethylcyclohexasiloxane
Also known as: Cyclohexasiloxane, 2,2,4,4,6,6,8,8,10,10,12,12-dodecamethyl-, Cyclohexasiloxane, dodecamethyl-, 2,2,4,4,6,6,8,8,10,10,12,12-Dodecamethylcyclohexasiloxane, EINECS 208-762-8, UNII-XHK3U310BA (+9 more)
CAS 540-97-6
Dodecamethylcyclohexasiloxane (CAS 540-97-6) is a chemical substance; key hazard signal: PBT (Article 57d); vPvB (Article 57e). Key regulatory status: SVHC Candidate List, REACH registered, 2 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ECHA SVHC.
SOURCE
noael studies public
NOAEL studies
8
SOURCE
chemical inventory jurisdictions
Regulatory lists
2
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
20 fields
Name
Dodecamethylcyclohexasiloxane
CAS Number
540-97-6
DTXSID
DTXSID6027183
Molecular Formula
C12H36O6Si6
InChI Key
IUMSDRXLFWAGNT-UHFFFAOYSA-N
Monoisotopic Mass
444.112748
Synonyms
Cyclohexasiloxane, 2,2,4,4,6,6,8,8,10,10,12,12-dodecamethyl-Cyclohexasiloxane, dodecamethyl-2,2,4,4,6,6,8,8,10,10,12,12-DodecamethylcyclohexasiloxaneEINECS 208-762-8UNII-XHK3U310BADC 246DC 246 FluidDow Corning 246Dow Corning 246 FluidHexadecamethylcyclohexasiloxaneSF 1258SH 246
Substance of Very High Concern (SVHC)
Candidate List status and reason under the ECHA REACH SVHC program.
SOURCE
ECHA (EU)
1 records
| Substance | Reason | Included |
|---|---|---|
| Dodecamethylcyclohexasiloxane | PBT (Article 57d); vPvB (Article 57e) | 27-Jun-2018 |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
17 records
Softener and conditionerSolvent
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
2 records
| List | Keyword | Source |
|---|---|---|
| Europe; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| CEDI | FDA | United States Food and Drug Administration (FDA) |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 8 of 8 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =1.22 | mg/m3 | DNEL local | inhalation | Human | ToxValDB_GESTIS_DNEL |
| XHK3U310BA | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| XHK3U310BA | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| XHK3U310BA | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| XHK3U310BA | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| >2000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| >50000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =545.922 | mg/m3 | LEL | inhalation | Rat | ToxValDB_EPA_TSCA_8e |
Showing 8 of 8 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Dodecamethylcyclohexasiloxane | 208-762-8 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
restricted
Max
≥0.1% w/w prohibited in all consumer and professional products under EU Reg 2024/1328; enforcement June 6, 2026
Category
volatile-silicone
Frequently Asked Questions
What regulatory lists include Dodecamethylcyclohexasiloxane?
Dodecamethylcyclohexasiloxane appears on 2 regulatory/inventory lists including Europe; Other direct contact consumer goods, CEDI. Source: EPA CPDat.
Is Dodecamethylcyclohexasiloxane a Substance of Very High Concern (SVHC)?
Yes, Dodecamethylcyclohexasiloxane is listed on the ECHA REACH Candidate List as a Substance of Very High Concern. Reason: PBT (Article 57d); vPvB (Article 57e). Source: ECHA SVHC Candidate List.
Is Dodecamethylcyclohexasiloxane used in cosmetics?
Yes, Dodecamethylcyclohexasiloxane is also indexed as a cosmetic ingredient under the name Cyclohexasiloxane. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Dodecamethylcyclohexasiloxane come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ECHA SVHC Candidate List, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.
Is Dodecamethylcyclohexasiloxane used outside industrial chemicals?
Dodecamethylcyclohexasiloxane also appears in cosmetics databases.