What is the NOAEL for 2,2,4-Trimethylpentane?
2,2,4-Trimethylpentane has 7 NOAEL studies in the database. The lowest reported value is 2035 mg/m3 via inhalation in Human. Source: ToxValDB GESTIS DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
2,2,4-Trimethylpentane
Also known as: Isooctane, iso-Octane, 4-01-00-00439, BRN 1696876, EINECS 208-759-1 (+2 more)
CAS 540-84-1
2,2,4-Trimethylpentane (CAS 540-84-1) is a chemical substance. Key regulatory status: REACH registered, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC.
Cross-Vertical Regulatory Divergence
2,2,4-Trimethylpentane is classified GHS Danger (H225, H304, H315, H336, H400, H410, H224, H302) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
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NOAEL studies
NOAEL studies
7
SOURCE
Chemical inventory jurisdictions
Regulatory lists
0
SOURCE
EU CLP Annex VI
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
13 fields
Name
2,2,4-Trimethylpentane
CAS Number
540-84-1
DTXSID
DTXSID7024370
Molecular Formula
C8H18
InChI Key
NHTMVDHEPJAVLT-UHFFFAOYSA-N
Monoisotopic Mass
114.140851
Synonyms
Isooctaneiso-Octane4-01-00-00439BRN 1696876EINECS 208-759-1UNII-QAB8F5669O(CH3)2CHCH2C(CH3)3
ICSC Chemical Safety
International Chemical Safety Card hazard and exposure summary.
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WHO/JECFA
1 records
| Field | Value |
|---|---|
| Short-term Effects | The substance is irritating to the eyes, skin and respiratory tract. The substance may cause effects on the kidneys, liver and nervous system. If this liquid is swallowed, aspiration into the lungs may result in chemical pneumonitis. |
| Long-term Effects | The substance defats the skin, which may cause dryness or cracking. |
| Routes of Exposure | The substance can be absorbed into the body by inhalation and by ingestion. |
Functional Uses
Industrial and product-use categories associated with this substance.
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EPA CPDat
2 records
Solvent
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
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NOAEL studies
Showing 7 of 7 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =2035 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB GESTIS DNEL |
| QAB8F5669O | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| QAB8F5669O | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| >2000 | mg/kg bw | LD50 | oral | Rat | NTP ICE acute oral |
| =51393 | mg/m3 | LEL | inhalation | Human | ToxValDB DOE Protective Action Criteria |
| =2336.04 | mg/m3 | NOAEL | inhalation | Rat | ToxValDB TX TCEQ |
| =5513.06 | mg/m3 | NOAEL | inhalation | Rat | ToxValDB TX TCEQ |
Showing 7 of 7 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
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ECHA
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 2,2,4-trimethylpentane | 208-759-1 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
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AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Rheology Modifier
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
ChEMBL / DailyMed
CHEMBL1797261
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Frequently Asked Questions
Is 2,2,4-Trimethylpentane used in cosmetics?
Yes, 2,2,4-Trimethylpentane is also indexed as a cosmetic ingredient under the name Isooctane. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 2,2,4-Trimethylpentane come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Does 2,2,4-Trimethylpentane have different safety status in cosmetics vs industrial chemicals?
2,2,4-Trimethylpentane is classified GHS Danger (H225, H304, H315, H336, H400, H410, H224, H302) in the chemicals database but is allowed in EU cosmetics.
Is 2,2,4-Trimethylpentane used outside industrial chemicals?
2,2,4-Trimethylpentane also appears in cosmetics, pharmaceutical databases.