Warning GHS07 NOAEL Data REACH Registered Cosmetic Ingredient

3,7-Dimethyl-2,6-octadienal

Also known as: Citral, Lemarome N, 2,6-Octadienal, 3,7-dimethyl-, 3-01-00-03053, BRN 1721871 (+9 more)

CAS 5392-40-5

3,7-Dimethyl-2,6-octadienal (CAS 5392-40-5) is a chemical substance with GHS signal word Warning; key hazard signal: H315; H317. Key regulatory status: REACH registered, 48 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, SCCS, ECHA REACH, ILO ICSC.

View cosmetic safety profile for Citral →

SOURCE noael studies public
NOAEL studies
100
SOURCE chemical inventory jurisdictions
Regulatory lists
48
SOURCE eu clp annex vi
GHS signal
Warning

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 20 fields
Name
3,7-Dimethyl-2,6-octadienal
CAS Number
5392-40-5
DTXSID
DTXSID6024836
Molecular Formula
C10H16O
InChI Key
WTEVQBCEXWBHNA-UHFFFAOYSA-N
Monoisotopic Mass
152.120115
Synonyms
CitralLemarome N2,6-Octadienal, 3,7-dimethyl-3-01-00-03053BRN 1721871Caswell No. 221B2,6-Dimethyloctadien-2,6-al-83,7-Dimethyl-1,2,6-octadienalEINECS 226-394-6EPA Pesticide Chemical Code 040510FEMA Number 2303NCI-C56348

GHS / CLP Classification

EU harmonized hazard classification, hazard statements, pictograms, and signal word.

SOURCE EU CLP Annex VI (ECHA) 1 classifications
Hazard ClassH-StatementsPictogramsSignal
Skin Irrit. 2; Skin Sens. 1H315; H317GHS07Warning

ICSC Chemical Safety

International Chemical Safety Card hazard and exposure summary.

SOURCE ILO/WHO International Chemical Safety Cards 1 records
FieldValue
GHS Signal WordWARNING
GHS Hazard StatementsCombustible liquid May be harmful if swallowed or in contact with skin Causes skin irritation May cause allergic skin reaction Toxic to aquatic life
Short-term EffectsThe substance is irritating to the skin.
Long-term EffectsRepeated or prolonged contact may cause skin sensitization.

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 60 records
Fragrance

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 48 records
ListKeywordSource
Europe; Personal care; restrictedEuropean CommissionCosIng
EuropeDanish Environmental Protection AgencyDanish EPA
active_ingredient; Europe; PesticidesEuropean CommissionCPCat
inert_ingredient; non_food_use; PesticidesEPACPCat
Cleaning products and household care - air freshener; detected; Europe; Vehicle - car interior - auto air freshenerDanish Environmental Protection AgencyDanish EPA
active_ingredient; Europe; PesticidesCommission of the European CommunitiesCPCat
air; detected; emissions; Europe; Vehicle - car interiorDanish Environmental Protection AgencyDanish EPA
detected; Europe; Vehicle - car interiorDanish Environmental Protection AgencyDanish EPA
air; detected; emissions; Europe; Vehicle - car interiorDanish Environmental Protection AgencyDanish EPA
children; Europe; Personal careDanish Environmental Protection AgencyDanish EPA
children; Europe; Personal care - specialized bath products - bath saltsDanish Environmental Protection AgencyDanish EPA
children; Europe; Personal care - general moisturizing - hand/body lotionDanish Environmental Protection AgencyDanish EPA
children; Europe; Personal careDanish Environmental Protection AgencyDanish EPA
children; Europe; Personal careDanish Environmental Protection AgencyDanish EPA
children; Europe; Personal careDanish Environmental Protection AgencyDanish EPA
children; detected; Europe; Personal care - body hygiene - hand soap; Personal care - fragrance; Personal care - hair styling and care - shampooDanish Environmental Protection AgencyDanish EPA
detected; Europe; Personal care - make-up and relatedDanish Environmental Protection AgencyDanish EPA
detected; Europe; Personal care - make-up and relatedDanish Environmental Protection AgencyDanish EPA
Cleaning products and household care - dishwasher and dishes; Cleaning products and household care - general household cleaning; detected; Europe; Other direct contact consumer goodsDanish Environmental Protection AgencyDanish EPA
consumer_product; detected; EuropeDanish Environmental Protection AgencyDanish EPA
Cleaning products and household care - laundry and fabric treatment - laundry stain remover; detected; EuropeDanish Environmental Protection AgencyDanish EPA
Cleaning products and household care - laundry and fabric treatment - laundry stain remover; detected; EuropeDanish Environmental Protection AgencyDanish EPA
detected; Europe; Personal care - sexual wellnessDanish Environmental Protection AgencyDanish EPA
detected; Europe; Personal care - sexual wellnessDanish Environmental Protection AgencyDanish EPA
Europe; Personal care - sexual wellnessDanish Environmental Protection AgencyDanish EPA
detected; Europe; Personal care - sexual wellnessDanish Environmental Protection AgencyDanish EPA
Europe; Personal care - deodorantDanish Environmental Protection AgencyDanish EPA
detected; Europe; Personal care - deodorantDanish Environmental Protection AgencyDanish EPA
detected; Europe; Personal care - deodorantDanish Environmental Protection AgencyDanish EPA
Australia; Food and drug - smoking-related productsNew Zealand ESRCPCat
Europe; Personal careDanish Environmental Protection AgencyDanish EPA
detected; Europe; Personal care - general moisturizing - hand/body lotionDanish Environmental Protection AgencyDanish EPA
detected; Europe; Personal care - deodorantDanish Environmental Protection AgencyDanish EPA
detected; Europe; Personal careDanish Environmental Protection AgencyDanish EPA
detected; Europe; Personal care - general moisturizing - hand/body lotionDanish Environmental Protection AgencyDanish EPA
Europe; nondetect; Personal care - hair styling and care - hair conditionerDanish Environmental Protection AgencyDanish EPA
detected; Europe; Personal care - make-up and related - tonerDanish Environmental Protection AgencyDanish EPA
Europe; Personal careDanish Environmental Protection AgencyDanish EPA
Europe; Personal careDanish Environmental Protection AgencyDanish EPA
Europe; Personal careDanish Environmental Protection AgencyDanish EPA

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 50 of 100 studies
ValueUnitEndpointRouteSpeciesSource
500----UnifiedCodex:SCCS_SHADOW:beta.noael_studies
>2500----UnifiedCodex:SCCS_SHADOW:beta.noael_studies
>10000----UnifiedCodex:SCCS_SHADOW:beta.noael_studies
~0.15mg/kg bw/dayADI--INCHEM_WHO_jecfa_jecmono_v52je15
~0.15mg/kg bw/dayADI--INCHEM_WHO_jecfa_jecmono_v52je15
<=0.5mg/kgADIoralHumanToxValDB_WHO_JECFA_ADI
=0.5mg/kg bw/dayADI--INCHEM_WHO_jecfa_jecmono_v52je15
=0.5mg/kg bw/dayADI--INCHEM_WHO_jecfa_jecmono_v52je15
=0.5mg/kg bw/dayADI (group)-ConsumersEFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx
=0.5mg/kg bw/dayADI (group)-ConsumersEFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx
13ug/mLCD54, EC200Dermal-NTP_ICE_skin_sensitization
15ug/mLCD54, EC200Dermal-NTP_ICE_skin_sensitization
2.2ug/mLCD86, EC150Dermal-NTP_ICE_skin_sensitization
3.7ug/mLCD86, EC150Dermal-NTP_ICE_skin_sensitization
8.41ug/mLCD86, EC150Dermal-NTP_ICE_skin_sensitization
12.97ug/mLCV70Dermal-NTP_ICE_skin_sensitization
16.6ug/mLCV75Dermal-NTP_ICE_skin_sensitization
24ug/mLCV75Dermal-NTP_ICE_skin_sensitization
0.04167%Concentration, 5% incidence of positive responsesDermalHumanNTP_ICE_skin_sensitization
0.125%Concentration, 5% incidence of positive responsesDermalHumanNTP_ICE_skin_sensitization
0.3125%Concentration, 5% incidence of positive responsesDermalHumanNTP_ICE_skin_sensitization
0.4%Concentration, 5% incidence of positive responsesDermalHumanNTP_ICE_skin_sensitization
range0.42%Concentration, 5% incidence of positive responsesDermalHumanNTP_ICE_skin_sensitization
0.7656%Concentration, 5% incidence of positive responsesDermalHumanNTP_ICE_skin_sensitization
1.025%Concentration, 5% incidence of positive responsesDermalHumanNTP_ICE_skin_sensitization
1.2%Concentration, 5% incidence of positive responsesDermalHumanNTP_ICE_skin_sensitization
2.1%Concentration, 5% incidence of positive responsesDermalHumanNTP_ICE_skin_sensitization
3.733%Concentration, 5% incidence of positive responsesDermalHumanNTP_ICE_skin_sensitization
0.03333%Concentration, one positive responseDermalHumanNTP_ICE_skin_sensitization
0.1%Concentration, one positive responseDermalHumanNTP_ICE_skin_sensitization
range0.2%Concentration, one positive responseDermalHumanNTP_ICE_skin_sensitization
0.25%Concentration, one positive responseDermalHumanNTP_ICE_skin_sensitization
0.3125%Concentration, one positive responseDermalHumanNTP_ICE_skin_sensitization
0.5%Concentration, one positive responseDermalHumanNTP_ICE_skin_sensitization
0.8%Concentration, one positive responseDermalHumanNTP_ICE_skin_sensitization
1%Concentration, one positive responseDermalHumanNTP_ICE_skin_sensitization
1.333%Concentration, one positive responseDermalHumanNTP_ICE_skin_sensitization
=9mg/m3DNEL systemicinhalationHumanToxValDB_GESTIS_DNEL
13.9%Depletion CysDermal-NTP_ICE_skin_sensitization
78.6%Depletion CysDermal-NTP_ICE_skin_sensitization
85.7%Depletion CysDermal-NTP_ICE_skin_sensitization
8.6%Depletion LysDermal-NTP_ICE_skin_sensitization
16.9%Depletion LysDermal-NTP_ICE_skin_sensitization
19.6%Depletion LysDermal-NTP_ICE_skin_sensitization
14%Depletion Lys + CysDermal-NTP_ICE_skin_sensitization
43.6%Depletion Lys + CysDermal-NTP_ICE_skin_sensitization
51.3%Depletion Lys + CysDermal-NTP_ICE_skin_sensitization
6.75uMEC1.5Dermal-NTP_ICE_skin_sensitization
7.66uMEC1.5Dermal-NTP_ICE_skin_sensitization
12.6uMEC1.5Dermal-NTP_ICE_skin_sensitization

Showing 50 of 100 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records
StatusNameEC NumberLink
RegisteredCitral226-394-6ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records
Inventory Status
listed

SCCS Opinions

EU Scientific Committee opinions tied to the matched substance.

SOURCE EU SCCS 1 opinions
OpinionDateConclusionMax Conc.Concerns
SCCS/1666/2429 July 2024Conditionally safe - QRA2 methodology indicates safety at proposed concentrations but methodology needs refinement before firm conclusionPer QRA2 proposed concentrations; labelling required >0.001% in leave-on and >0.01% in rinse-off productsSkin sensitisation; QRA2 methodology not yet fully validated; case-by-case assessment required for fragrances

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
restricted
Max
10 ppm in leave-on products, 100 ppm in rinse-off products
Category
fragrance
View full cosmetic safety profile →

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL
ChEMBL Phase
Not listed
Adverse Events
3
Bioactivity
0
View full pharmaceutical profile →

Food Safety Data

Same-CAS food additive, ADI, and GRAS records where available.

SOURCE EFSA / FDA GRAS 1 records

ADI: 0-0.5 mg/kg bw (1979) mg/kg bw

View full food safety profile →

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the GHS hazard classification for 3,7-Dimethyl-2,6-octadienal?

3,7-Dimethyl-2,6-octadienal (CAS 5392-40-5) is classified under EU CLP Annex VI as Skin Irrit. 2; Skin Sens. 1 with signal word Warning. Hazard statements: H315; H317. Source: EU CLP Annex VI (ECHA).

What is the NOAEL for 3,7-Dimethyl-2,6-octadienal?

3,7-Dimethyl-2,6-octadienal has 100 NOAEL studies in the database. The lowest reported value is 0.03333 % via Dermal in Human. Source: NTP_ICE_skin_sensitization.

What regulatory lists include 3,7-Dimethyl-2,6-octadienal?

3,7-Dimethyl-2,6-octadienal appears on 29 regulatory/inventory lists including Europe; Personal care; restricted, Europe, active_ingredient; Europe; Pesticides, and 26 more. Source: EPA CPDat.

Is 3,7-Dimethyl-2,6-octadienal used in cosmetics?

Yes, 3,7-Dimethyl-2,6-octadienal is also indexed as a cosmetic ingredient under the name Citral. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 3,7-Dimethyl-2,6-octadienal come from?

Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Is 3,7-Dimethyl-2,6-octadienal used outside industrial chemicals?

3,7-Dimethyl-2,6-octadienal also appears in cosmetics, pharmaceutical, food safety, cannabis databases.