Warning GHS07 NOAEL Data REACH Registered Cosmetic Ingredient

3,7-Dimethyl-2,6-octadienal

Also known as: Citral, Lemarome N, 2,6-Octadienal, 3,7-dimethyl-, 3-01-00-03053, BRN 1721871 (+9 more)

CAS 5392-40-5

3,7-Dimethyl-2,6-octadienal (CAS 5392-40-5) is a chemical substance with GHS signal word Warning; key hazard signal: H315; H317. Key regulatory status: REACH registered, 48 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, SCCS, ECHA REACH, ILO ICSC.

View cosmetic safety profile for Citral →

SOURCE noael studies public

NOAEL studies

100

SOURCE chemical inventory jurisdictions

Regulatory lists

SOURCE eu clp annex vi

GHS signal

Warning

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 20 fields

Name

3,7-Dimethyl-2,6-octadienal

CAS Number

5392-40-5

DTXSID

DTXSID6024836

Molecular Formula

C10H16O

InChI Key

WTEVQBCEXWBHNA-UHFFFAOYSA-N

Monoisotopic Mass

152.120115

Synonyms

CitralLemarome N2,6-Octadienal, 3,7-dimethyl-3-01-00-03053BRN 1721871Caswell No. 221B2,6-Dimethyloctadien-2,6-al-83,7-Dimethyl-1,2,6-octadienalEINECS 226-394-6EPA Pesticide Chemical Code 040510FEMA Number 2303NCI-C56348

GHS / CLP Classification

EU harmonized hazard classification, hazard statements, pictograms, and signal word.

SOURCE EU CLP Annex VI (ECHA) 1 classifications

Hazard Class	H-Statements	Pictograms	Signal
Skin Irrit. 2; Skin Sens. 1	H315; H317	GHS07	Warning

ICSC Chemical Safety

International Chemical Safety Card hazard and exposure summary.

SOURCE ILO/WHO International Chemical Safety Cards 1 records

Field	Value
GHS Signal Word	WARNING
GHS Hazard Statements	Combustible liquid May be harmful if swallowed or in contact with skin Causes skin irritation May cause allergic skin reaction Toxic to aquatic life
Short-term Effects	The substance is irritating to the skin.
Long-term Effects	Repeated or prolonged contact may cause skin sensitization.

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 60 records

Fragrance

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 48 records

List	Keyword	Source
Europe; Personal care; restricted	European Commission	CosIng
Europe	Danish Environmental Protection Agency	Danish EPA
active_ingredient; Europe; Pesticides	European Commission	CPCat
inert_ingredient; non_food_use; Pesticides	EPA	CPCat
Cleaning products and household care - air freshener; detected; Europe; Vehicle - car interior - auto air freshener	Danish Environmental Protection Agency	Danish EPA
active_ingredient; Europe; Pesticides	Commission of the European Communities	CPCat
air; detected; emissions; Europe; Vehicle - car interior	Danish Environmental Protection Agency	Danish EPA
detected; Europe; Vehicle - car interior	Danish Environmental Protection Agency	Danish EPA
air; detected; emissions; Europe; Vehicle - car interior	Danish Environmental Protection Agency	Danish EPA
children; Europe; Personal care	Danish Environmental Protection Agency	Danish EPA
children; Europe; Personal care - specialized bath products - bath salts	Danish Environmental Protection Agency	Danish EPA
children; Europe; Personal care - general moisturizing - hand/body lotion	Danish Environmental Protection Agency	Danish EPA
children; Europe; Personal care	Danish Environmental Protection Agency	Danish EPA
children; Europe; Personal care	Danish Environmental Protection Agency	Danish EPA
children; Europe; Personal care	Danish Environmental Protection Agency	Danish EPA
children; detected; Europe; Personal care - body hygiene - hand soap; Personal care - fragrance; Personal care - hair styling and care - shampoo	Danish Environmental Protection Agency	Danish EPA
detected; Europe; Personal care - make-up and related	Danish Environmental Protection Agency	Danish EPA
detected; Europe; Personal care - make-up and related	Danish Environmental Protection Agency	Danish EPA
Cleaning products and household care - dishwasher and dishes; Cleaning products and household care - general household cleaning; detected; Europe; Other direct contact consumer goods	Danish Environmental Protection Agency	Danish EPA
consumer_product; detected; Europe	Danish Environmental Protection Agency	Danish EPA
Cleaning products and household care - laundry and fabric treatment - laundry stain remover; detected; Europe	Danish Environmental Protection Agency	Danish EPA
Cleaning products and household care - laundry and fabric treatment - laundry stain remover; detected; Europe	Danish Environmental Protection Agency	Danish EPA
detected; Europe; Personal care - sexual wellness	Danish Environmental Protection Agency	Danish EPA
detected; Europe; Personal care - sexual wellness	Danish Environmental Protection Agency	Danish EPA
Europe; Personal care - sexual wellness	Danish Environmental Protection Agency	Danish EPA
detected; Europe; Personal care - sexual wellness	Danish Environmental Protection Agency	Danish EPA
Europe; Personal care - deodorant	Danish Environmental Protection Agency	Danish EPA
detected; Europe; Personal care - deodorant	Danish Environmental Protection Agency	Danish EPA
detected; Europe; Personal care - deodorant	Danish Environmental Protection Agency	Danish EPA
Australia; Food and drug - smoking-related products	New Zealand ESR	CPCat
Europe; Personal care	Danish Environmental Protection Agency	Danish EPA
detected; Europe; Personal care - general moisturizing - hand/body lotion	Danish Environmental Protection Agency	Danish EPA
detected; Europe; Personal care - deodorant	Danish Environmental Protection Agency	Danish EPA
detected; Europe; Personal care	Danish Environmental Protection Agency	Danish EPA
detected; Europe; Personal care - general moisturizing - hand/body lotion	Danish Environmental Protection Agency	Danish EPA
Europe; nondetect; Personal care - hair styling and care - hair conditioner	Danish Environmental Protection Agency	Danish EPA
detected; Europe; Personal care - make-up and related - toner	Danish Environmental Protection Agency	Danish EPA
Europe; Personal care	Danish Environmental Protection Agency	Danish EPA
Europe; Personal care	Danish Environmental Protection Agency	Danish EPA
Europe; Personal care	Danish Environmental Protection Agency	Danish EPA

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 50 of 100 studies

Value	Unit	Endpoint	Route	Species	Source
500	-	-	-	-	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
>2500	-	-	-	-	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
>10000	-	-	-	-	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
~0.15	mg/kg bw/day	ADI	-	-	INCHEM_WHO_jecfa_jecmono_v52je15
~0.15	mg/kg bw/day	ADI	-	-	INCHEM_WHO_jecfa_jecmono_v52je15
<=0.5	mg/kg	ADI	oral	Human	ToxValDB_WHO_JECFA_ADI
=0.5	mg/kg bw/day	ADI	-	-	INCHEM_WHO_jecfa_jecmono_v52je15
=0.5	mg/kg bw/day	ADI	-	-	INCHEM_WHO_jecfa_jecmono_v52je15
=0.5	mg/kg bw/day	ADI (group)	-	Consumers	EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx
=0.5	mg/kg bw/day	ADI (group)	-	Consumers	EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx
13	ug/mL	CD54, EC200	Dermal	-	NTP_ICE_skin_sensitization
15	ug/mL	CD54, EC200	Dermal	-	NTP_ICE_skin_sensitization
2.2	ug/mL	CD86, EC150	Dermal	-	NTP_ICE_skin_sensitization
3.7	ug/mL	CD86, EC150	Dermal	-	NTP_ICE_skin_sensitization
8.41	ug/mL	CD86, EC150	Dermal	-	NTP_ICE_skin_sensitization
12.97	ug/mL	CV70	Dermal	-	NTP_ICE_skin_sensitization
16.6	ug/mL	CV75	Dermal	-	NTP_ICE_skin_sensitization
24	ug/mL	CV75	Dermal	-	NTP_ICE_skin_sensitization
0.04167	%	Concentration, 5% incidence of positive responses	Dermal	Human	NTP_ICE_skin_sensitization
0.125	%	Concentration, 5% incidence of positive responses	Dermal	Human	NTP_ICE_skin_sensitization
0.3125	%	Concentration, 5% incidence of positive responses	Dermal	Human	NTP_ICE_skin_sensitization
0.4	%	Concentration, 5% incidence of positive responses	Dermal	Human	NTP_ICE_skin_sensitization
range0.42	%	Concentration, 5% incidence of positive responses	Dermal	Human	NTP_ICE_skin_sensitization
0.7656	%	Concentration, 5% incidence of positive responses	Dermal	Human	NTP_ICE_skin_sensitization
1.025	%	Concentration, 5% incidence of positive responses	Dermal	Human	NTP_ICE_skin_sensitization
1.2	%	Concentration, 5% incidence of positive responses	Dermal	Human	NTP_ICE_skin_sensitization
2.1	%	Concentration, 5% incidence of positive responses	Dermal	Human	NTP_ICE_skin_sensitization
3.733	%	Concentration, 5% incidence of positive responses	Dermal	Human	NTP_ICE_skin_sensitization
0.03333	%	Concentration, one positive response	Dermal	Human	NTP_ICE_skin_sensitization
0.1	%	Concentration, one positive response	Dermal	Human	NTP_ICE_skin_sensitization
range0.2	%	Concentration, one positive response	Dermal	Human	NTP_ICE_skin_sensitization
0.25	%	Concentration, one positive response	Dermal	Human	NTP_ICE_skin_sensitization
0.3125	%	Concentration, one positive response	Dermal	Human	NTP_ICE_skin_sensitization
0.5	%	Concentration, one positive response	Dermal	Human	NTP_ICE_skin_sensitization
0.8	%	Concentration, one positive response	Dermal	Human	NTP_ICE_skin_sensitization
1	%	Concentration, one positive response	Dermal	Human	NTP_ICE_skin_sensitization
1.333	%	Concentration, one positive response	Dermal	Human	NTP_ICE_skin_sensitization
=9	mg/m3	DNEL systemic	inhalation	Human	ToxValDB_GESTIS_DNEL
13.9	%	Depletion Cys	Dermal	-	NTP_ICE_skin_sensitization
78.6	%	Depletion Cys	Dermal	-	NTP_ICE_skin_sensitization
85.7	%	Depletion Cys	Dermal	-	NTP_ICE_skin_sensitization
8.6	%	Depletion Lys	Dermal	-	NTP_ICE_skin_sensitization
16.9	%	Depletion Lys	Dermal	-	NTP_ICE_skin_sensitization
19.6	%	Depletion Lys	Dermal	-	NTP_ICE_skin_sensitization
14	%	Depletion Lys + Cys	Dermal	-	NTP_ICE_skin_sensitization
43.6	%	Depletion Lys + Cys	Dermal	-	NTP_ICE_skin_sensitization
51.3	%	Depletion Lys + Cys	Dermal	-	NTP_ICE_skin_sensitization
6.75	uM	EC1.5	Dermal	-	NTP_ICE_skin_sensitization
7.66	uM	EC1.5	Dermal	-	NTP_ICE_skin_sensitization
12.6	uM	EC1.5	Dermal	-	NTP_ICE_skin_sensitization

Showing 50 of 100 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records

Status	Name	EC Number	Link
Registered	Citral	226-394-6	ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

SCCS Opinions

EU Scientific Committee opinions tied to the matched substance.

SOURCE EU SCCS 1 opinions

Opinion	Date	Conclusion	Max Conc.	Concerns
SCCS/1666/24	29 July 2024	Conditionally safe - QRA2 methodology indicates safety at proposed concentrations but methodology needs refinement before firm conclusion	Per QRA2 proposed concentrations; labelling required >0.001% in leave-on and >0.01% in rinse-off products	Skin sensitisation; QRA2 methodology not yet fully validated; case-by-case assessment required for fragrances

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

restricted

Max

10 ppm in leave-on products, 100 ppm in rinse-off products

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL

ChEMBL Phase

Not listed

Adverse Events

Bioactivity

View full pharmaceutical profile →

Food Safety Data

Same-CAS food additive, ADI, and GRAS records where available.

SOURCE EFSA / FDA GRAS 1 records

ADI: 0-0.5 mg/kg bw (1979) mg/kg bw

View full food safety profile →

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the GHS hazard classification for 3,7-Dimethyl-2,6-octadienal?

3,7-Dimethyl-2,6-octadienal (CAS 5392-40-5) is classified under EU CLP Annex VI as Skin Irrit. 2; Skin Sens. 1 with signal word Warning. Hazard statements: H315; H317. Source: EU CLP Annex VI (ECHA).

What is the NOAEL for 3,7-Dimethyl-2,6-octadienal?

3,7-Dimethyl-2,6-octadienal has 100 NOAEL studies in the database. The lowest reported value is 0.03333 % via Dermal in Human. Source: NTP_ICE_skin_sensitization.

What regulatory lists include 3,7-Dimethyl-2,6-octadienal?

3,7-Dimethyl-2,6-octadienal appears on 29 regulatory/inventory lists including Europe; Personal care; restricted, Europe, active_ingredient; Europe; Pesticides, and 26 more. Source: EPA CPDat.

Is 3,7-Dimethyl-2,6-octadienal used in cosmetics?

Yes, 3,7-Dimethyl-2,6-octadienal is also indexed as a cosmetic ingredient under the name Citral. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 3,7-Dimethyl-2,6-octadienal come from?

Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Is 3,7-Dimethyl-2,6-octadienal used outside industrial chemicals?

3,7-Dimethyl-2,6-octadienal also appears in cosmetics, pharmaceutical, food safety, cannabis databases.