NOAEL Data Cosmetic Ingredient

2,4,5,6-Pyrimidinetetramine sulfate (1:1)

Also known as: tetra-Aminopyrimidine sulfate, 2,4,5,6-Pyrimidinetetramine, sulfate (1:1), Pyrimidinetetramine, sulfate (1:1), 2,4,5,6-Tetraaminopyrimidine sulfate (1:1), NSC 227862 (+10 more)

CAS 5392-28-9

2,4,5,6-Pyrimidinetetramine sulfate (1:1) (CAS 5392-28-9) is a chemical substance. Key regulatory status: 2 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat.

View cosmetic safety profile for Tetraaminopyrimidine Sulfate →

SOURCE noael studies public

NOAEL studies

SOURCE chemical inventory jurisdictions

Regulatory lists

SOURCE eu clp annex vi

GHS signal

Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 21 fields

Name

2,4,5,6-Pyrimidinetetramine sulfate (1:1)

CAS Number

5392-28-9

DTXSID

DTXSID0037023

Molecular Formula

C4H8N6.H2O4S

InChI Key

MQEFDQWUCTUJCP-UHFFFAOYSA-N

Monoisotopic Mass

238.048424

Synonyms

tetra-Aminopyrimidine sulfate2,4,5,6-Pyrimidinetetramine, sulfate (1:1)Pyrimidinetetramine, sulfate (1:1)2,4,5,6-Tetraaminopyrimidine sulfate (1:1)NSC 227862Sulfate de pyrimidinetetrayltetraaminepyrimidinetetrayltetraamine sulphatePyrimidintetrayltetraaminsulfatsulfato de pirimidinatetrailtetraamina2,4,5,6-Tetraaminopyrimidine sulfatetetraaminopyrimidine monosulfateEC 226-393-0

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 1 records

Dye

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 2 records

List	Keyword	Source
Europe; Personal care; restricted	European Commission	CosIng
Europe; Personal care - hair coloring	Danish Environmental Protection Agency	Danish EPA

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 35 of 35 studies

Value	Unit	Endpoint	Route	Species	Source
28	-	-	-	-	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
3	unitless	EPA Classification	Ocular	Rabbit	NTP_ICE_eye_irritation
53QQY0I99M	UNII	FDA UNII substance identifier	-	-	openFDA substances
53QQY0I99M	UNII	FDA UNII substance identifier	-	-	openFDA substances
53QQY0I99M	UNII	FDA UNII substance identifier	-	-	openFDA substances
53QQY0I99M	UNII	FDA UNII substance identifier	-	-	openFDA substances
=28	-	NOAEL	-	-	SCCS_vision_codex
=28	-	NOAEL	-	-	SCCS_vision_codex
=28	-	NOAEL	-	-	SCCS_vision_codex
=28	-	NOAEL	-	-	SCCS_vision_codex
=150	mg/kg bw/d	NOAEL	oral	rat	SCCS_vision_codex
=150	mg/kg bw/d	NOAEL	oral	rat	SCCS_vision_codex
=150	mg/kg bw/d	NOAEL	oral	rat	SCCS_vision_codex
=150	mg/kg bw/d	NOAEL	oral	rat	SCCS_vision_codex
=375	mg/kg/d	NOAEL	dermal	rat	SCCS_vision_codex
=375	mg/kg bw/day	NOAEL	oral	rat	SCCS_vision_codex
=375	mg/kg/d	NOAEL	dermal	rat	SCCS_vision_codex
=375	mg/kg bw/day	NOAEL	oral	rat	SCCS_vision_codex
=375	mg/kg/d	NOAEL	dermal	rat	SCCS_vision_codex
=375	mg/kg bw/day	NOAEL	oral	rat	SCCS_vision_codex
=375	mg/kg/d	NOAEL	dermal	rat	SCCS_vision_codex
=375	mg/kg bw/day	NOAEL	oral	rat	SCCS_vision_codex
=500	mg/kg bw	NOAEL	oral	human	SCCS_vision_codex
=500	mg/kg bw	NOAEL	oral	human	SCCS_vision_codex
=500	mg/kg bw	NOAEL	oral	human	SCCS_vision_codex
=500	mg/kg bw	NOAEL	oral	human	SCCS_vision_codex
=600	mg/kg bw	NOAEL	oral	human	SCCS_vision_codex
=600	mg/kg bw	NOAEL	oral	human	SCCS_vision_codex
=600	mg/kg bw	NOAEL	oral	human	SCCS_vision_codex
=600	mg/kg bw	NOAEL	oral	human	SCCS_vision_codex
375	mg/kg/d	developmental toxicity	dermal	rat	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
150	mg/kg bw/d	repeated dose toxicity	oral	rat	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
375	mg/kg bw/day	repeated dose toxicity	oral	rat	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
500	mg/kg bw	repeated dose toxicity	oral	human	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
600	mg/kg bw	repeated dose toxicity	oral	human	UnifiedCodex:SCCS_SHADOW:beta.noael_studies

Showing 35 of 35 studies

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

restricted

Max

3.4%

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL CHEMBL3185354

ChEMBL Phase

Not listed

Adverse Events

Bioactivity

View full pharmaceutical profile →

Frequently Asked Questions

What is the NOAEL for 2,4,5,6-Pyrimidinetetramine sulfate (1:1)?

2,4,5,6-Pyrimidinetetramine sulfate (1:1) has 35 NOAEL studies in the database. The lowest reported value is 3 unitless via Ocular in Rabbit. Source: NTP_ICE_eye_irritation.

What regulatory lists include 2,4,5,6-Pyrimidinetetramine sulfate (1:1)?

2,4,5,6-Pyrimidinetetramine sulfate (1:1) appears on 2 regulatory/inventory lists including Europe; Personal care; restricted, Europe; Personal care - hair coloring. Source: EPA CPDat.

Is 2,4,5,6-Pyrimidinetetramine sulfate (1:1) used in cosmetics?

Yes, 2,4,5,6-Pyrimidinetetramine sulfate (1:1) is also indexed as a cosmetic ingredient under the name Tetraaminopyrimidine Sulfate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 2,4,5,6-Pyrimidinetetramine sulfate (1:1) come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.

Is 2,4,5,6-Pyrimidinetetramine sulfate (1:1) used outside industrial chemicals?

2,4,5,6-Pyrimidinetetramine sulfate (1:1) also appears in cosmetics, pharmaceutical databases.