What is the NOAEL for Domiphen bromide?
Domiphen bromide has 9 NOAEL studies in the database. The lowest reported value is 96.3 unitless via Ocular in Rabbit. Source: NTP_ICE_eye_irritation.
NOAEL Data
Cosmetic Ingredient
Domiphen bromide
Also known as: Ammonium bromide, dodecyldimethyl(2-phenoxyethyl)-, Bradasol, EINECS 208-702-0, NSC-39415, beta-Phenoxyethyldimethyldodecylammonium bromide (+2 more)
CAS 538-71-6
Domiphen bromide (CAS 538-71-6) is a chemical substance. Key regulatory status: 1 regulatory/inventory list, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS.
SOURCE
noael studies public
NOAEL studies
9
SOURCE
chemical inventory jurisdictions
Regulatory lists
1
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
13 fields
Name
Domiphen bromide
CAS Number
538-71-6
DTXSID
DTXSID5033468
Molecular Formula
C22H40NO.BrH
InChI Key
OJIYIVCMRYCWSE-UHFFFAOYSA-M
Monoisotopic Mass
414.237153
Synonyms
Ammonium bromide, dodecyldimethyl(2-phenoxyethyl)-BradasolEINECS 208-702-0NSC-39415beta-Phenoxyethyldimethyldodecylammonium bromideDomipheni bromidumUNII-R4CY19YS7C
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
4 records
BiocideDeodorizerPharmaceutical
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
1 records
| List | Keyword | Source |
|---|---|---|
| pharmaceutical | US International Trade Commission | CPCat |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 9 of 9 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 96.3 | unitless | Draize rabbit irritation score | Ocular | Rabbit | NTP_ICE_eye_irritation |
| R4CY19YS7C | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| R4CY19YS7C | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| R4CY19YS7C | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| R4CY19YS7C | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 1 | unitless | GHS Classification | Ocular | Rabbit | NTP_ICE_eye_irritation |
| 0.32 | %/sec | Intensity | Ocular | - | NTP_ICE_eye_irritation |
| - | s | Lag time | Ocular | - | NTP_ICE_eye_irritation |
| 57.1 | % | Plateau level | Ocular | - | NTP_ICE_eye_irritation |
Showing 9 of 9 studies
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
restricted
Max
0.1%
Category
Cosmetic Ingredient
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
DOMIPHEN BROMIDE
ChEMBL Phase
2
Adverse Events
0
Bioactivity
5
Frequently Asked Questions
What regulatory lists include Domiphen bromide?
Domiphen bromide appears on 1 regulatory/inventory list including pharmaceutical. Source: EPA CPDat.
Is Domiphen bromide used in cosmetics?
Yes, Domiphen bromide is also indexed as a cosmetic ingredient under the name Domiphen Bromide. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Domiphen bromide come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Is Domiphen bromide used outside industrial chemicals?
Domiphen bromide also appears in cosmetics, pharmaceutical databases.