What is the NOAEL for C.I. Pigment Red 57, calcium salt (1:1)?
C.I. Pigment Red 57, calcium salt (1:1) has 8 NOAEL studies in the database. The lowest reported value is 4.4 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
C.I. Pigment Red 57, calcium salt (1:1)
Also known as: 2-Naphthalenecarboxylic acid, 3-hydroxy-4-[(4-methyl-2-sulfophenyl)azo]-, calcium salt (1:1), Brilliant Carmine 6B, Lithol Rubine BCA, Calcium 3-hydroxy-4-[(4-methyl-2-sulfonatophenyl)diazenyl]naphthalene-2-carboxylate, 2-Naphthalenecarboxylic acid, 3-hydroxy-4-[2-(4-methyl-2-sulfophenyl)diazenyl]-, calcium salt (1:1) (+5 more)
CAS 5281-04-9
C.I. Pigment Red 57, calcium salt (1:1) (CAS 5281-04-9) is a chemical substance. Key regulatory status: REACH registered, 5 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
Cross-Vertical Regulatory Divergence
C.I. Pigment Red 57, calcium salt (1:1) is prohibited in EU cosmetics at max 0.4% but has active industrial GHS classifications.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status/eu_max; Chemicals: ghs_classifications.signal_word
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noael studies public
NOAEL studies
8
SOURCE
chemical inventory jurisdictions
Regulatory lists
5
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
16 fields
Name
C.I. Pigment Red 57, calcium salt (1:1)
CAS Number
5281-04-9
DTXSID
DTXSID7027594
Molecular Formula
C18H14N2O6S.Ca
InChI Key
PZTQVMXMKVTIRC-UHFFFAOYSA-L
Monoisotopic Mass
426.019848
Synonyms
2-Naphthalenecarboxylic acid, 3-hydroxy-4-[(4-methyl-2-sulfophenyl)azo]-, calcium salt (1:1)Brilliant Carmine 6BLithol Rubine BCACalcium 3-hydroxy-4-[(4-methyl-2-sulfonatophenyl)diazenyl]naphthalene-2-carboxylate2-Naphthalenecarboxylic acid, 3-hydroxy-4-[2-(4-methyl-2-sulfophenyl)diazenyl]-, calcium salt (1:1)D & C Red No. 7EINECS 226-109-53-Hydroxy-4-((2-sulfo-p-tolyl)azo)-2-naphthalenecarboxylic acid, calcium salt (1:1)UNII-ECW0LZ41X8D&C Red No. 7
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
16 records
DyePigment
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
5 records
| List | Keyword | Source |
|---|---|---|
| Europe; plastic_additive | European Chemicals Agency | European Chemicals Agency (ECHA) |
| Canada; Personal care; Substances in PCP - Canada (4/2014) | Government of Canada | CPCat |
| pharmaceutical | FDA | United States Food and Drug Administration (FDA) |
| Personal care | FDA | United States Food and Drug Administration (FDA) |
| Indirect additives food contact (10/2018) | FDA | United States Food and Drug Administration (FDA) |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 8 of 8 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =4.4 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| =16.4 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| ECW0LZ41X8 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| ECW0LZ41X8 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| ECW0LZ41X8 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| ECW0LZ41X8 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| >1.518 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| >5000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
Showing 8 of 8 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Calcium 3-hydroxy-4-[(4-methyl-2-sulphonatophenyl)azo]-2-naphthoate | 226-109-5 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
prohibited
Max
0.4%
Category
Other
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL2028348
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
1
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
E180 — ADI: 1.5 mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include C.I. Pigment Red 57, calcium salt (1:1)?
C.I. Pigment Red 57, calcium salt (1:1) appears on 5 regulatory/inventory lists including Europe; plastic_additive, Canada; Personal care; Substances in PCP - Canada (4/2014), pharmaceutical, and 2 more. Source: EPA CPDat.
Is C.I. Pigment Red 57, calcium salt (1:1) used in cosmetics?
Yes, C.I. Pigment Red 57, calcium salt (1:1) is also indexed as a cosmetic ingredient under the name D&C Red No. 7 (CI 15850. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for C.I. Pigment Red 57, calcium salt (1:1) come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Does C.I. Pigment Red 57, calcium salt (1:1) have different safety status in cosmetics vs industrial chemicals?
C.I. Pigment Red 57, calcium salt (1:1) is prohibited in EU cosmetics at max 0.4% but has active industrial GHS classifications.
Is C.I. Pigment Red 57, calcium salt (1:1) used outside industrial chemicals?
C.I. Pigment Red 57, calcium salt (1:1) also appears in cosmetics, pharmaceutical, food safety, cannabis databases.