What is the NOAEL for Copper gluconate?
Copper gluconate has 15 NOAEL studies in the database. The lowest reported value is 0.371 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Copper gluconate
Also known as: Copper, bis(D-gluconato-κO1,κO2)-, Copper, bis(D-gluconato-O1,O2)-, Bis(D-gluconato-κO1,κO2)copper, D-Gluconic acid, copper complex, Cupric gluconate (+15 more)
CAS 527-09-3
Copper gluconate (CAS 527-09-3) is a chemical substance. Key regulatory status: REACH registered, 8 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
SOURCE
noael studies public
NOAEL studies
15
SOURCE
chemical inventory jurisdictions
Regulatory lists
8
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
26 fields
Name
Copper gluconate
CAS Number
527-09-3
DTXSID
DTXSID4035960
Molecular Formula
2C6H12O7.Cu
InChI Key
OCUCCJIRFHNWBP-IYEMJOQQSA-L
Monoisotopic Mass
455.046203
Synonyms
Copper, bis(D-gluconato-κO1,κO2)-Copper, bis(D-gluconato-O1,O2)-Bis(D-gluconato-κO1,κO2)copperD-Gluconic acid, copper complexCupric gluconateD-Gluconic acid, copper(2+) saltHelshas CuLabicuperDi-D-gluconate de cuivrecopper di-D-gluconateKupferdi-D-gluconatdi-D-gluconato de cobre
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
8 records
HumectantSoftener and conditionerNo specific technical functionPharmaceuticalFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
8 records
| List | Keyword | Source |
|---|---|---|
| active_ingredient; animal_products; Europe; pharmaceutical; residue | EU | CPCat |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Canada; pharmaceutical | DrugBank | DrugBank |
| inert_ingredient; Pesticides | EPA | CPCat |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| Europe; supplements | EU | CPCat |
| Europe; food_additive; supplements | EU | CPCat |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 15 of 15 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =0.371 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| RV823G6G67 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| RV823G6G67 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| RV823G6G67 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| RV823G6G67 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =10 | mg/day | NOAEL | oral | Human | ToxValDB_Copper_Manufacturers |
| 30 | mg/kg bw/day | NOAEL | oral | mouse | COSMOS_DB |
| 180 | mg/kg bw/day | NOAEL | oral | dog | COSMOS_DB |
| 1140 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| =15 | mg/kg bw/day | NOEL | oral | Dog | ToxValDB_EFSA |
| =15 | mg/kg bw/day | NOEL | - | Dog | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| =15 | mg/kg bw/day | NOEL | - | Dog | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| =27 | mg/kg bw/day | NOEL | oral | Rat | ToxValDB_EFSA |
| =27 | mg/kg bw/day | NOEL | - | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| =27 | mg/kg bw/day | NOEL | - | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
Showing 15 of 15 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Copper di-D-gluconate | 208-408-2 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
1%
Category
Other
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
ChEMBL Phase
Not listed
Adverse Events
134
Bioactivity
0
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
1 food-safety record found.
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Copper gluconate?
Copper gluconate appears on 7 regulatory/inventory lists including active_ingredient; animal_products; Europe; pharmaceutical; residue, food_additive; Substances Added to Food (formerly EAFUS) (2/2019), Canada; pharmaceutical, and 4 more. Source: EPA CPDat.
Is Copper gluconate used in cosmetics?
Yes, Copper gluconate is also indexed as a cosmetic ingredient under the name Copper Gluconate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Copper gluconate come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is Copper gluconate used outside industrial chemicals?
Copper gluconate also appears in cosmetics, pharmaceutical, food safety, cannabis databases.