What is the NOAEL for L-Cysteine hydrochloride?
L-Cysteine hydrochloride has 9 NOAEL studies in the database. The lowest reported value is 1.8 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
L-Cysteine hydrochloride
Also known as: cisteina, clorhidrato, Cystein chloride, CYSTEINE CHLORHYDRATE, Cysteine chlorohydrate, cysteine hydrochloride (+11 more)
CAS 52-89-1
L-Cysteine hydrochloride (CAS 52-89-1) is a chemical substance. Key regulatory status: REACH registered, 2 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, ECHA REACH.
SOURCE
noael studies public
NOAEL studies
9
SOURCE
chemical inventory jurisdictions
Regulatory lists
2
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
22 fields
Name
L-Cysteine hydrochloride
CAS Number
52-89-1
DTXSID
DTXSID0020367
Molecular Formula
C3H7NO2S.ClH
InChI Key
IFQSXNOEEPCSLW-DKWTVANSSA-N
Monoisotopic Mass
156.996427
Synonyms
cisteina, clorhidratoCystein chlorideCYSTEINE CHLORHYDRATECysteine chlorohydratecysteine hydrochlorideCysteine, chlorhydrateCysteinhydrochloridCysteine, L-, monohydrochlorideEINECS 200-157-73-Mercaptoalanine hydrochlorideUNII-A9U1687S1SCysteine HCl (anhydrous)
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
15 records
AntioxidantSoftener and conditionerReducing agentHair waving or straighteningFlavouring and nutrientLeavening agentFillerFood preservative
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
2 records
| List | Keyword | Source |
|---|---|---|
| Europe | European Commission | Fl@vis |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 9 of 9 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =1.8 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| A9U1687S1S | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| A9U1687S1S | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| A9U1687S1S | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| A9U1687S1S | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 100 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 200 | mg/kg bw/day | NOAEL | oral | mouse | COSMOS_DB |
| 3000 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 8000 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
Showing 9 of 9 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Cysteine hydrochloride | 200-157-7 | ECHA overview → |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Antioxidant
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CYSTEINE HYDROCHLORIDE
ChEMBL Phase
4
Adverse Events
0
Bioactivity
0
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
1 food-safety record found.
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include L-Cysteine hydrochloride?
L-Cysteine hydrochloride appears on 2 regulatory/inventory lists including Europe, food_additive; Substances Added to Food (formerly EAFUS) (2/2019). Source: EPA CPDat.
Is L-Cysteine hydrochloride used in cosmetics?
Yes, L-Cysteine hydrochloride is also indexed as a cosmetic ingredient under the name CYSTEINE HCL. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for L-Cysteine hydrochloride come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is L-Cysteine hydrochloride used outside industrial chemicals?
L-Cysteine hydrochloride also appears in cosmetics, pharmaceutical, food safety, cannabis databases.