Danger GHS07GHS05GHS09 NOAEL Data REACH Registered Cosmetic Ingredient

Bronopol

Also known as: 2-Bromo-2-nitro-1,3-propanediol, BRN 1705868, beta-Bromo-beta-nitrotrimethyleneglycol, Bronosol, Caswell No. 116A (+7 more)

CAS 52-51-7

Bronopol (CAS 52-51-7) is a chemical substance with GHS signal word Danger; key hazard signal: H312; H302; H335; H315; H318; H400. Key regulatory status: REACH registered, 51 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, ECHA REACH, ILO ICSC.

View cosmetic safety profile for Bronopol →

SOURCE noael studies public
NOAEL studies
98
SOURCE chemical inventory jurisdictions
Regulatory lists
51
SOURCE eu clp annex vi
GHS signal
Danger

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 18 fields
Name
Bronopol
CAS Number
52-51-7
DTXSID
DTXSID8024652
Molecular Formula
C3H6BrNO4
InChI Key
LVDKZNITIUWNER-UHFFFAOYSA-N
Monoisotopic Mass
198.94802
Synonyms
2-Bromo-2-nitro-1,3-propanediolBRN 1705868beta-Bromo-beta-nitrotrimethyleneglycolBronosolCaswell No. 116AEINECS 200-143-0EPA Pesticide Chemical Code 216400Lexgard bronopolBronopoluBronopolumUNII-6PU1E16C9W1,2-Bromo-2-nitropropane-1,3-diol

GHS / CLP Classification

EU harmonized hazard classification, hazard statements, pictograms, and signal word.

SOURCE EU CLP Annex VI (ECHA) 1 classifications
Hazard ClassH-StatementsPictogramsSignal
Acute Tox. 4 *; Acute Tox. 4 *; STOT SE 3; Skin Irrit. 2; Eye Dam. 1; Aquatic Acute 1H312; H302; H335; H315; H318; H400GHS07; GHS05; GHS09Danger

ICSC Chemical Safety

International Chemical Safety Card hazard and exposure summary.

SOURCE ILO/WHO International Chemical Safety Cards 1 records
FieldValue
GHS Signal WordDANGER
GHS Hazard StatementsFlammable solid Harmful if swallowed or in contact with skin Causes skin irritation Causes serious eye damage May cause respiratory irritation Very toxic to aquatic life with long lasting effects
Short-term EffectsThe substance is corrosive to the eyes. The substance is irritating to the skin and respiratory tract.
Long-term EffectsRepeated or prolonged contact may cause skin sensitization.
Routes of ExposureThe substance can be absorbed into the body by inhalation of its aerosol, through the skin and by ingestion.

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 60 records
PreservativeBiocideProcessing aids not otherwise specifiedDeodorizerNo specific technical function

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 51 records
ListKeywordSource
children; Europe; Personal care - general moisturizing - hand/body lotionDanish Environmental Protection AgencyDanish EPA
children; Europe; Personal care - body hygiene - body washDanish Environmental Protection AgencyDanish EPA
children; Europe; Personal care - hair styling and care - shampooDanish Environmental Protection AgencyDanish EPA
children; Europe; Personal care - specialized bath products - bubble bathDanish Environmental Protection AgencyDanish EPA
children; Europe; Personal careDanish Environmental Protection AgencyDanish EPA
children; Europe; Personal careDanish Environmental Protection AgencyDanish EPA
children; Europe; Personal careDanish Environmental Protection AgencyDanish EPA
CEDIFDAUnited States Food and Drug Administration (FDA)
Indirect additives food contact (10/2018)FDAUnited States Food and Drug Administration (FDA)
fracking; waterNY Department of ConservationCPCat
Arts and crafts/Office supplies - general arts and crafts supplies - arts and crafts paint; EuropeDanish Environmental Protection AgencyDanish EPA
Europe; Personal care - body hygiene - hand soapDanish Environmental Protection AgencyDanish EPA
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
Europe; Personal care - deodorantDanish Environmental Protection AgencyDanish EPA
Arts and crafts/Office supplies - general arts and crafts supplies - arts and crafts paint; EuropeDanish Environmental Protection AgencyDanish EPA
consumer_product; EuropeDanish Environmental Protection AgencyDanish EPA
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesCalifornia Department of Pesticide RegulationState of California
active_ingredient; Europe; PesticidesEuropean CommissionCPCat
active_ingredient; AustraliaAustralian Pesticides and Veterinary Medicines AuthorityCPCat
inert_ingredient; non_food_use; PesticidesEPACPCat
pharmaceuticalUS International Trade CommissionCPCat
active_ingredient; Europe; PesticidesCommission of the European CommunitiesCPCat
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 50 of 98 studies
ValueUnitEndpointRouteSpeciesSource
2.114%Concentration, 5% incidence of positive responsesDermalHumanNTP_ICE_skin_sensitization
0.4545%Concentration, one positive responseDermalHumanNTP_ICE_skin_sensitization
=2.5mg/m3DNEL localinhalationHumanToxValDB_GESTIS_DNEL
=3.5mg/m3DNEL systemicinhalationHumanToxValDB_GESTIS_DNEL
1unitlessEPA ClassificationOcularRabbitNTP_ICE_eye_irritation
1unitlessEPA ClassificationOcularRabbitNTP_ICE_eye_irritation
1unitlessEPA ClassificationOcularRabbitNTP_ICE_eye_irritation
1unitlessEPA ClassificationOcularRabbitNTP_ICE_eye_irritation
2unitlessEPA ClassificationInhalation-NTP_ICE_acute_inhalation
3unitlessEPA ClassificationInhalation-NTP_ICE_acute_inhalation
1unitlessEPA classificationDermalRabbitNTP_ICE_skin_irritation
=2UnitlessEPA classificationoralRat (Female)NTP_ICE_acute_oral
2unitlessEPA classificationDermalRabbitNTP_ICE_skin_irritation
3unitlessEPA classificationDermalRatNTP_ICE_acute_dermal
=3UnitlessEPA classificationoralRat (Female)NTP_ICE_acute_oral
=3UnitlessEPA classificationoralRat (Female)NTP_ICE_acute_oral
4unitlessEPA classificationDermalRatNTP_ICE_acute_dermal
6PU1E16C9WUNIIFDA UNII substance identifier--openFDA substances
6PU1E16C9WUNIIFDA UNII substance identifier--openFDA substances
6PU1E16C9WUNIIFDA UNII substance identifier--openFDA substances
6PU1E16C9WUNIIFDA UNII substance identifier--openFDA substances
1unitlessGHS ClassificationDermalGuinea pigNTP_ICE_skin_sensitization
4unitlessGHS ClassificationInhalation-NTP_ICE_acute_inhalation
=4UnitlessGHS classificationoralRat (Female)NTP_ICE_acute_oral
=4UnitlessGHS classificationoralRat (Female)NTP_ICE_acute_oral
=4UnitlessGHS classificationoralRat (Female)NTP_ICE_acute_oral
5unitlessGHS classificationDermalRatNTP_ICE_acute_dermal
-%Incidence of positive responsesDermalHumanNTP_ICE_skin_sensitization
11.83%Incidence of positive responsesDermalHumanNTP_ICE_skin_sensitization
1395ug/cm2Induction dose per skin areaDermalHumanNTP_ICE_skin_sensitization
3488ug/cm2Induction dose per skin areaDermalHumanNTP_ICE_skin_sensitization
1474ug/cm2Induction dose per skin area, 5% incidence of positive responsesDermalHumanNTP_ICE_skin_sensitization
317ug/cm2Induction dose per skin area, one positive responseDermalHumanNTP_ICE_skin_sensitization
0.21mg/LLC50Inhalation-NTP_ICE_acute_inhalation
range0.52mg/LLC50Inhalation-NTP_ICE_acute_inhalation
1.69mg/LLC50Inhalation-NTP_ICE_acute_inhalation
>5mg/LLC50Inhalation-NTP_ICE_acute_inhalation
=1030mg/kg bwLD50oralRat (Female)NTP_ICE_acute_oral
>2000mg/kgLD50DermalRatNTP_ICE_acute_dermal
=2000mg/kg bwLD50oralRat (Female)NTP_ICE_acute_oral
>5000mg/kgLD50DermalRatNTP_ICE_acute_dermal
=4.1mg/kg bw/dayLELoralDogToxValDB_ToxRefDB
=4.1mg/kg bw/dayLELoraldog (beagle; beagle)ToxRefDB_ToxRefDB_v3_pod.csv
=4.27mg/kg bw/dayLELoralDogToxValDB_ToxRefDB
=4.27mg/kg bw/dayLELoraldog (beagle; beagle)ToxRefDB_ToxRefDB_v3_pod.csv
=10mg/kg bw/dayLELoralRatToxValDB_ToxRefDB
=10mg/kg bw/dayLELoralrat (sprague dawley; Sprague Dawley)ToxRefDB_ToxRefDB_v3_pod.csv
=80mg/kg bw/dayLELoralRabbitToxValDB_ToxRefDB
=80mg/kg bw/dayLELoralrabbit (new zealand white; New Zealand White)ToxRefDB_ToxRefDB_v3_pod.csv
=150mg/kg bw/dayLELoralRatToxValDB_ToxRefDB

Showing 50 of 98 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records
StatusNameEC NumberLink
RegisteredBronopol200-143-0ECHA overview →

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
restricted
Max
0.1%
Category
preservative
View full cosmetic safety profile →

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL BRONOPOL
ChEMBL Phase
2
Adverse Events
0
Bioactivity
2
View full pharmaceutical profile →

Frequently Asked Questions

What is the GHS hazard classification for Bronopol?

Bronopol (CAS 52-51-7) is classified under EU CLP Annex VI as Acute Tox. 4 *; Acute Tox. 4 *; STOT SE 3; Skin Irrit. 2; Eye Dam. 1; Aquatic Acute 1 with signal word Danger. Hazard statements: H312; H302; H335; H315; H318; H400. Source: EU CLP Annex VI (ECHA).

What is the NOAEL for Bronopol?

Bronopol has 98 NOAEL studies in the database. The lowest reported value is 0 % via Dermal in Human. Source: NTP_ICE_skin_sensitization.

What regulatory lists include Bronopol?

Bronopol appears on 20 regulatory/inventory lists including children; Europe; Personal care - general moisturizing - hand/body lotion, children; Europe; Personal care - body hygiene - body wash, children; Europe; Personal care - hair styling and care - shampoo, and 17 more. Source: EPA CPDat.

Is Bronopol used in cosmetics?

Yes, Bronopol is also indexed as a cosmetic ingredient under the name Bronopol. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Bronopol come from?

Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, EPA DSSTox, ECHA REACH, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.

Does Bronopol have different safety status in cosmetics vs industrial chemicals?

Bronopol is classified GHS Danger (H312, H302, H335, H315, H318, H400) in the chemicals database but is restricted in EU cosmetics at max 0.1%.

Is Bronopol used outside industrial chemicals?

Bronopol also appears in cosmetics, pharmaceutical databases.