What is the NOAEL for Canthaxanthin?
Canthaxanthin has 13 NOAEL studies in the database. The lowest reported value is 0.03 mg/kg via oral in Human. Source: ToxValDB_WHO_JECFA_ADI.
NOAEL Data
Cosmetic Ingredient
Canthaxanthin
Also known as: 4-07-00-02680, BRN 1898520, Carotene-4,4'-dione, beta-, EINECS 208-187-2, UNII-4C3C6403MU (+12 more)
CAS 514-78-3
Canthaxanthin (CAS 514-78-3) is a chemical substance. Key regulatory status: 4 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS.
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noael studies public
NOAEL studies
13
SOURCE
chemical inventory jurisdictions
Regulatory lists
4
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eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
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DSSTox identifiers
23 fields
Name
Canthaxanthin
CAS Number
514-78-3
DTXSID
DTXSID0022727
Molecular Formula
C40H52O2
InChI Key
FDSDTBUPSURDBL-DKLMTRRASA-N
Monoisotopic Mass
564.396731
Synonyms
4-07-00-02680BRN 1898520Carotene-4,4'-dione, beta-EINECS 208-187-2UNII-4C3C6403MU2,4,4-trimethyl-3-[(1E,3E,5E,7E,9E,11E,13E,15E,17E)-3,7,12,16-tetramethyl-18-(2,6,6-trimethyl-3-oxocyclohex-1-en-1-yl)octadeca-1,3,5,7,9,11,13,15,17-nonaen-1-yl]cyclohex-2-en-1-one4,4'-Diketo-b-carotene4,4'-Diketo-beta-carotene4,4'-dioxo-beta-caroteneAll-trans,beta-Carotene-4,4'-dioneCantaxanthinCantaxanthine
Functional Uses
Industrial and product-use categories associated with this substance.
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EPA CPDat
5 records
Dye
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
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EPA CPDat
4 records
| List | Keyword | Source |
|---|---|---|
| general_foods | FDA | United States Food and Drug Administration (FDA) |
| pharmaceutical | FDA | United States Food and Drug Administration (FDA) |
| Europe; Personal care | European Commission | CosIng |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
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NOAEL studies
Showing 13 of 13 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| <=0.03 | mg/kg | ADI | oral | Human | ToxValDB_WHO_JECFA_ADI |
| =0.03 | mg/kg bw/day | ADI | - | Consumers | EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx |
| =0.03 | mg/kg bw/day | ADI | - | Consumers | EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx |
| >=0.2 | mg/kg bw/day | BMDL (05) | oral | Human | ToxValDB_EFSA |
| 4C3C6403MU | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 4C3C6403MU | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 4C3C6403MU | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 4C3C6403MU | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =0.25 | mg/kg bw/day | NOAEL | oral | Human | ToxValDB_EFSA |
| =0.25 | mg/kg bw/day | NOAEL | - | Human | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| =0.25 | mg/kg bw/day | NOAEL | - | Human | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| 5 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 12.5 | mg/kg bw/day | NOAEL | oral | mouse | COSMOS_DB |
Showing 13 of 13 studies
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
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AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
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CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Colorant
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
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EMBL-EBI ChEMBL
CANTHAXANTHIN
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
1
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
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EFSA / FDA GRAS
1 records
ADI: 0.03 mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
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Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Canthaxanthin?
Canthaxanthin appears on 4 regulatory/inventory lists including general_foods, pharmaceutical, Europe; Personal care, and 1 more. Source: EPA CPDat.
Is Canthaxanthin used in cosmetics?
Yes, Canthaxanthin is also indexed as a cosmetic ingredient under the name CI 40850. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Canthaxanthin come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is Canthaxanthin used outside industrial chemicals?
Canthaxanthin also appears in cosmetics, pharmaceutical, food safety, cannabis databases.