What is the NOAEL for Abietic acid?
Abietic acid has 18 NOAEL studies in the database. The lowest reported value is 11.42 ratio via Dermal. Source: NTP ICE skin sensitization.
NOAEL Data
Cosmetic Ingredient
Abietic acid
Also known as: 1-Phenanthrenecarboxylic acid, 1,2,3,4,4a,4b,5,6,10,10a-decahydro-1,4a-dimethyl-7-(1-methylethyl)-, (1R,4aR,4bR,10aR)-, (-)-Abietic acid, 1-Phenanthrenecarboxylic acid, 1,2,3,4,4a,4b,5,6, 10,10a-decahydro-1,4a-dimethyl-7-(1-methylethyl)-, [1R-(1α,4aβ,4bα,10aα)], 1-Phenanthrenecarboxylic acid, 1,2,3,4,4a,4b,5,6,10,10a-decahydro-1,4a-dimethyl-7-(1-methylethyl)-, [1R-(1α,4aβ,4bα,10aα)]-, 7,13-Abietadien-18-oic acid (+15 more)
CAS 514-10-3
Abietic acid (CAS 514-10-3) is a chemical substance. Key regulatory status: 3 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS.
SOURCE
NOAEL studies
NOAEL studies
18
SOURCE
Chemical inventory jurisdictions
Regulatory lists
3
SOURCE
EU CLP Annex VI
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
26 fields
Name
Abietic acid
CAS Number
514-10-3
DTXSID
DTXSID7022047
Molecular Formula
C20H30O2
InChI Key
RSWGJHLUYNHPMX-ONCXSQPRSA-N
Monoisotopic Mass
302.22458
Synonyms
1-Phenanthrenecarboxylic acid, 1,2,3,4,4a,4b,5,6,10,10a-decahydro-1,4a-dimethyl-7-(1-methylethyl)-, (1R,4aR,4bR,10aR)-(-)-Abietic acid1-Phenanthrenecarboxylic acid, 1,2,3,4,4a,4b,5,6, 10,10a-decahydro-1,4a-dimethyl-7-(1-methylethyl)-, [1R-(1α,4aβ,4bα,10aα)]1-Phenanthrenecarboxylic acid, 1,2,3,4,4a,4b,5,6,10,10a-decahydro-1,4a-dimethyl-7-(1-methylethyl)-, [1R-(1α,4aβ,4bα,10aα)]-7,13-Abietadien-18-oic acidAbietic acid, (-)-l-Abietic acidPodocarpa-7,13-dien-15-oic acid, 13-isopropyl-(1R,4aR,4bR,10aR)-1,2,3,4,4a,4b,5,6,10,10a-Decahydro-1,4a-dimethyl-7-(1-methylethyl)-1-phenanthrenecarboxylic acidAbieta-7,13-diene-18-oic acidNSC 25149Odomit B 10
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
3 records
Surfactant (surface active agent)EmulsifierFragrance
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
3 records
| List | Keyword | Source |
|---|---|---|
| CEDI | FDA | United States Food and Drug Administration (FDA) |
| Indirect additives food contact (10/2018) | FDA | United States Food and Drug Administration (FDA) |
| consumer_product | P&G | Proctor & Gamble |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 18 of 18 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 13.1 | ug/mL | CD86, EC150 | Dermal | - | NTP ICE skin sensitization |
| 36.2 | ug/mL | CD86, EC150 | Dermal | - | NTP ICE skin sensitization |
| 72.49 | ug/mL | CV70 | Dermal | - | NTP ICE skin sensitization |
| 89.6 | ug/mL | CV75 | Dermal | - | NTP ICE skin sensitization |
| 99.9 | % | Depletion Cys | Dermal | - | NTP ICE skin sensitization |
| 15.9 | % | Depletion Lys | Dermal | - | NTP ICE skin sensitization |
| 16.3 | % | Depletion Lys | Dermal | - | NTP ICE skin sensitization |
| 58 | % | Depletion Lys + Cys | Dermal | - | NTP ICE skin sensitization |
| 58.1 | % | Depletion Lys + Cys | Dermal | - | NTP ICE skin sensitization |
| 16.56 | uM | EC1.5 | Dermal | - | NTP ICE skin sensitization |
| 15 | % | EC3 | Dermal | Mouse | NTP ICE skin sensitization |
| 34.74 | uM | EC3 | Dermal | - | NTP ICE skin sensitization |
| V3DHX33184 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| V3DHX33184 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| V3DHX33184 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| V3DHX33184 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 104.61 | uM | IC50 | Dermal | - | NTP ICE skin sensitization |
| 11.42 | ratio | Imax | Dermal | - | NTP ICE skin sensitization |
Showing 18 of 18 studies
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
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AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Surfactant
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
ChEMBL / DailyMed
ABIETIC ACID
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
6
Frequently Asked Questions
What regulatory lists include Abietic acid?
Abietic acid appears on 3 regulatory/inventory lists including CEDI, Indirect additives food contact (10/2018), consumer_product. Source: EPA CPDat.
Is Abietic acid used in cosmetics?
Yes, Abietic acid is also indexed as a cosmetic ingredient under the name Abietic Acid. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Abietic acid come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Is Abietic acid used outside industrial chemicals?
Abietic acid also appears in cosmetics, pharmaceutical databases.