Also known as: 3,5,7-Triazatricyclo(3.3.1.1(superscript 3,7))decane, 1-(3-chloro-2-propenyl)-, chloride, (Z)-, 1-(3-Chloroallyl)-3,5,7-triaza-1-azoniaadamantane chloride, cis form, Hexamethylenetetramine cis-chloroallyl chloride, cis-N-(3-Chloroallyl) hexaminium chloride, cis-1-(3-Chloroallyl)-3,5,7-triaza-1-azoniaadamantane chloride (+2 more)
CAS 51229-78-8
Chloroallyl methenamine chloride (CAS 51229-78-8) is a chemical substance with GHS signal word Warning; key hazard signal: H228; H361d ***; H302; H315; H317; H411. Key regulatory status: REACH registered, 8 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, SCCS, ECHA REACH.
Chloroallyl methenamine chloride is prohibited in EU cosmetics but has active industrial GHS classifications (H228, H361d, H302, H315, H317, H411).
CAS, identifiers, formula, and alternate names for the matched substance record.
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Flam. Sol. 2; Repr. 2; Acute Tox. 4 *; Skin Irrit. 2; Skin Sens. 1; Aquatic Chronic 2 | H228; H361d ***; H302; H315; H317; H411 | GHS02; GHS08; GHS07; GHS09 | Warning |
Industrial and product-use categories associated with this substance.
Inventory, screening, and regulatory list matches from public chemical databases.
| List | Keyword | Source |
|---|---|---|
| fracking; water | NY Department of Conservation | CPCat |
| banned; Europe; Personal care | European Commission | CosIng |
| banned; Europe; Personal care | European Commission | CosIng |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| active_ingredient; Europe; Pesticides | Commission of the European Communities | CPCat |
| Europe; Personal care - hair styling and care - shampoo-dandruff | Danish Environmental Protection Agency | Danish EPA |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Personal care - general moisturizing | P&G | Proctor & Gamble |
Toxicology endpoints rendered from public NOAEL study rows.
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 33.0600013516662 | uM | AC50 | - | - | NTP_ICE_endocrine |
| 88.08310039 | uM | AC50 | - | - | NTP_ICE_endocrine |
| 8.64900672367284 | uM | ACC | - | - | NTP_ICE_endocrine |
| 34.2177971752606 | uM | ACC | - | - | NTP_ICE_endocrine |
| 45.75 | % | Concentration, 5% incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 5 | % | Concentration, one positive response | Dermal | Human | NTP_ICE_skin_sensitization |
| LIT014L4RH | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| LIT014L4RH | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| LIT014L4RH | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| LIT014L4RH | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0.5464 | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 3937 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| 36020 | ug/cm2 | Induction dose per skin area, 5% incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| =25 | mg/kg bw/day | LEL | oral | Rat | ToxValDB_ToxRefDB |
| =25 | mg/kg bw/day | LEL | oral | rat (fischer; Fischer 344) | ToxRefDB_ToxRefDB_v3_pod.csv |
| =75 | mg/kg bw/day | LEL | oral | Rat | ToxValDB_ToxRefDB |
| =75 | mg/kg bw/day | LOAEL | oral | Rat | ToxValDB_ToxRefDB |
| =75 | mg/kg bw/day | LOAEL | oral | rat (fischer; Fischer 344) | ToxRefDB_ToxRefDB_v3_pod.csv |
| =15 | % | LOEL | dermal | Mouse | ToxValDB_ECOTOX |
| 75 | mg/kg bw/day | LOEL | Oral | Rat | NTP_ICE_dart |
| 75 | mg/kg bw/day | LOEL | Oral | Rat | NTP_ICE_dart |
| 75 | mg/kg bw/day | LOEL | Oral | Rat | NTP_ICE_dart |
| 0.00109 | unitless | Model Score | - | - | NTP_ICE_endocrine |
| 0.00343 | unitless | Model Score | - | - | NTP_ICE_endocrine |
| 0.0169 | unitless | Model Score | - | - | NTP_ICE_endocrine |
| 0.0337 | unitless | Model Score | - | - | NTP_ICE_endocrine |
| >- | mg/kg bw/day | NEL | oral | rat (fischer; Fischer 344) | ToxRefDB_ToxRefDB_v3_pod.csv |
| =25 | mg/kg bw/day | NEL | oral | Rat | ToxValDB_ToxRefDB |
| 4 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
Showing 29 of 29 studies
Registration status from the ECHA REACH registered substances database.
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | cis-1-(3-chloroallyl)-3,5,7-triaza-1- azoniaadamantane chloride (cis CTAC) | 426-020-3 | ECHA overview → |
Australian industrial chemicals inventory status and applicable conditions.
EU Scientific Committee opinions tied to the matched substance.
| Opinion | Date | Conclusion | Max Conc. | Concerns |
|---|---|---|---|---|
| SCCS/1449/11 | 13-14 December 2011 | Not found | - | Formaldehyde release; sensitization |
Same-CAS cosmetic ingredient record for cross-vertical context.
Same-CAS pharmaceutical records from drug and bioactivity sources.
Chloroallyl methenamine chloride (CAS 51229-78-8) is classified under EU CLP Annex VI as Flam. Sol. 2; Repr. 2; Acute Tox. 4 *; Skin Irrit. 2; Skin Sens. 1; Aquatic Chronic 2 with signal word Warning. Hazard statements: H228; H361d ***; H302; H315; H317; H411. Source: EU CLP Annex VI (ECHA).
Chloroallyl methenamine chloride has 29 NOAEL studies in the database. The lowest reported value is 0 mg/kg bw/day via oral in rat (fischer; Fischer 344). Source: ToxRefDB_ToxRefDB_v3_pod.csv.
Chloroallyl methenamine chloride appears on 7 regulatory/inventory lists including fracking; water, banned; Europe; Personal care, inert_ingredient; non_food_use; Pesticides, and 4 more. Source: EPA CPDat.
Yes, Chloroallyl methenamine chloride is also indexed as a cosmetic ingredient under the name Quaternium-15. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Chloroallyl methenamine chloride is prohibited in EU cosmetics but has active industrial GHS classifications (H228, H361d, H302, H315, H317, H411).
Chloroallyl methenamine chloride also appears in cosmetics, pharmaceutical databases.