What is the NOAEL for Hydroxyproline?
Hydroxyproline has 6 NOAEL studies in the database. The lowest reported value is RMB44WO89X UNII. Source: openFDA substances.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Hydroxyproline
Also known as: L-Proline, 4-hydroxy-, (4R)-, (4R)-4-hydroxy-L-proline
CAS 51-35-4
Hydroxyproline (CAS 51-35-4) is a chemical substance. Key regulatory status: REACH registered, 2 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, ECHA REACH.
SOURCE
noael studies public
NOAEL studies
6
SOURCE
chemical inventory jurisdictions
Regulatory lists
2
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
8 fields
Name
Hydroxyproline
CAS Number
51-35-4
DTXSID
DTXSID10883225
Molecular Formula
C5H9NO3
InChI Key
PMMYEEVYMWASQN-DMTCNVIQSA-N
Monoisotopic Mass
131.058243
Synonyms
L-Proline, 4-hydroxy-, (4R)-(4R)-4-hydroxy-L-proline
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
10 records
Surfactant (surface active agent)Anti-static agentSoftener and conditioner
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
2 records
| List | Keyword | Source |
|---|---|---|
| Canada; pharmaceutical | DrugBank | DrugBank |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 6 of 6 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| RMB44WO89X | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| RMB44WO89X | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| RMB44WO89X | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| RMB44WO89X | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| >4000 | mg/kg bw/day | LEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =200 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
Showing 6 of 6 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | L-4-hydroxyproline | 200-091-9 | ECHA overview → |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Amino Acid
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL352418
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
3
Frequently Asked Questions
What regulatory lists include Hydroxyproline?
Hydroxyproline appears on 2 regulatory/inventory lists including Canada; pharmaceutical, food_additive; Substances Added to Food (formerly EAFUS) (2/2019). Source: EPA CPDat.
Is Hydroxyproline used in cosmetics?
Yes, Hydroxyproline is also indexed as a cosmetic ingredient under the name L-Hydroxyproline. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Hydroxyproline come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Is Hydroxyproline used outside industrial chemicals?
Hydroxyproline also appears in cosmetics, pharmaceutical databases.