Also known as: Calciferol, (1S,3Z)-4-Methylene-3-[(2E)-2-[(1R,3aS,7aR)-octahydro-7a-methyl-1-[(1R,2E,4R)-1,4,5-trimethyl-2-hexen-1-yl]-4H-inden-4-ylidene]ethylidene]cyclohexanol, Activated ergosterol, Calciferolum, EINECS 200-014-9 (+15 more)
CAS 50-14-6
Ergocalciferol (CAS 50-14-6) is a chemical substance with GHS signal word Danger; key hazard signal: H330; H311; H301; H372 **. Key regulatory status: 9 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat.
Ergocalciferol is classified GHS Danger (H330, H311, H301, H372) in the chemicals database but is allowed in EU cosmetics.
CAS, identifiers, formula, and alternate names for the matched substance record.
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Acute Tox. 2 *; Acute Tox. 3 *; Acute Tox. 3 *; STOT RE 1 | H330; H311; H301; H372 ** | GHS06; GHS08 | Danger |
Industrial and product-use categories associated with this substance.
Inventory, screening, and regulatory list matches from public chemical databases.
| List | Keyword | Source |
|---|---|---|
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| active_ingredient; Europe; Pesticides | European Commission | CPCat |
| pharmaceutical | US International Trade Commission | CPCat |
| Europe; supplements | EU | CPCat |
| Europe; food_additive; supplements | EU | CPCat |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Canada; pharmaceutical | DrugBank | DrugBank |
| active_ingredient; Europe; Pesticides | Commission of the European Communities | CPCat |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
Toxicology endpoints rendered from public NOAEL study rows.
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 0.0439261949180241 | uM | AC50 | - | - | NTP_ICE_endocrine |
| 68.5886524519628 | uM | AC50 | - | - | NTP_ICE_endocrine |
| 0.0374534272245393 | uM | ACC | - | - | NTP_ICE_endocrine |
| 38.9487931 | uM | ACC | - | - | NTP_ICE_endocrine |
| VS041H42XC | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| VS041H42XC | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| VS041H42XC | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| VS041H42XC | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =10 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
| 0.0286 | unitless | Model Score | - | - | NTP_ICE_endocrine |
| 0.0908 | unitless | Model Score | - | - | NTP_ICE_endocrine |
| 0.01 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 0.25 | mg/kg bw/day | NOAEL | oral | dog | COSMOS_DB |
| 0.5 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 0.625 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 0.825 | mg/kg bw/day | NOAEL | oral | horse | COSMOS_DB |
| 1.25 | mg/kg bw/day | NOAEL | oral | mouse | COSMOS_DB |
| 1.9 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 2.5 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 2.9 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 3.75 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 4 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 5 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 7.5 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 12.5 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 50 | mg/kg bw/day | NOAEL | oral | gerbil | COSMOS_DB |
| 76 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 100 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 299 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
Showing 30 of 30 studies
Same-CAS cosmetic ingredient record for cross-vertical context.
Same-CAS pharmaceutical records from drug and bioactivity sources.
Same-CAS food additive, ADI, and GRAS records where available.
1 food-safety record found.
View full food safety profile →Same-CAS cannabis compliance and lab records where available.
1 cannabis record found in efsa substances.
View full cannabis profile →Ergocalciferol (CAS 50-14-6) is classified under EU CLP Annex VI as Acute Tox. 2 *; Acute Tox. 3 *; Acute Tox. 3 *; STOT RE 1 with signal word Danger. Hazard statements: H330; H311; H301; H372 **. Source: EU CLP Annex VI (ECHA).
Ergocalciferol has 30 NOAEL studies in the database. The lowest reported value is 0.0374534272245393 uM. Source: NTP_ICE_endocrine.
Ergocalciferol appears on 7 regulatory/inventory lists including inert_ingredient; non_food_use; Pesticides, active_ingredient; Europe; Pesticides, pharmaceutical, and 4 more. Source: EPA CPDat.
Yes, Ergocalciferol is also indexed as a cosmetic ingredient under the name Ergocalciferol. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, EPA DSSTox, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Ergocalciferol is classified GHS Danger (H330, H311, H301, H372) in the chemicals database but is allowed in EU cosmetics.
Ergocalciferol also appears in cosmetics, pharmaceutical, food safety, cannabis databases.