What is the NOAEL for Isopropyl-o-cresol?
Isopropyl-o-cresol has 23 NOAEL studies in the database. The lowest reported value is 0.439 mg/m3 via inhalation in Human. Source: ToxValDB GESTIS DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Isopropyl-o-cresol
Also known as: Carvacrol, 4-06-00-03331, BRN 1860514, Caswell No. 511, o-Cresol, 5-isopropyl- (+15 more)
CAS 499-75-2
Isopropyl-o-cresol (CAS 499-75-2) is a chemical substance. Key regulatory status: REACH registered, 5 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
SOURCE
NOAEL studies
NOAEL studies
23
SOURCE
Chemical inventory jurisdictions
Regulatory lists
5
SOURCE
EU CLP Annex VI
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
26 fields
Name
Isopropyl-o-cresol
CAS Number
499-75-2
DTXSID
DTXSID6042074
Molecular Formula
C10H14O
InChI Key
RECUKUPTGUEGMW-UHFFFAOYSA-N
Monoisotopic Mass
150.104465
Synonyms
Carvacrol4-06-00-03331BRN 1860514Caswell No. 511o-Cresol, 5-isopropyl-p-Cymene, 2-hydroxy-Cymene-2-ol, p-EINECS 207-889-6EPA Pesticide Chemical Code 022104FEMA No. 22451-Hydroxy-2-methyl-5-isopropylbenzenePhenol, 3-isopropyl-6-methyl-
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
9 records
FragranceFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
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EPA CPDat
5 records
| List | Keyword | Source |
|---|---|---|
| active_ingredient; Europe; Pesticides | Commission of the European Communities | CPCat |
| IFRA Transparency | IFRA | IFRA |
| Europe | European Commission | Fl@vis |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| consumer_product | P&G | Proctor & Gamble |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 23 of 23 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =0.439 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB GESTIS DNEL |
| =9.87 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB GESTIS DNEL |
| =14.8 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB GESTIS DNEL |
| 9B1J4V995Q | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 9B1J4V995Q | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 9B1J4V995Q | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 9B1J4V995Q | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | % | Incidence of positive responses | Dermal | Human | NTP ICE skin sensitization |
| 2700 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP ICE skin sensitization |
| =810 | mg/kg bw | LD50 | oral | Rat | NTP ICE acute oral |
| =2000 | mg/kg bw/day | LEL | oral | Pig | EFSA |
| =4 | mg | LOEL | oral | Mouse | ToxValDB ECOTOX |
| - | unitless | Model Score | - | - | NTP ICE endocrine |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP ICE skin sensitization |
| 12.1 | % | Viability (240 minutes) | Dermal | - | NTP ICE skin irritation |
| 12.5 | % | Viability (240 minutes) | Dermal | - | NTP ICE skin irritation |
| 14.7 | % | Viability (240 minutes) | Dermal | - | NTP ICE skin irritation |
| 48.9 | % | Viability (3 minutes) | Dermal | - | NTP ICE skin irritation |
| 57.3 | % | Viability (3 minutes) | Dermal | - | NTP ICE skin irritation |
| 73.4 | % | Viability (3 minutes) | Dermal | - | NTP ICE skin irritation |
| 23.4 | % | Viability (60 minutes) | Dermal | - | NTP ICE skin irritation |
| 26.5 | % | Viability (60 minutes) | Dermal | - | NTP ICE skin irritation |
| 31.1 | % | Viability (60 minutes) | Dermal | - | NTP ICE skin irritation |
Showing 23 of 23 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Carvacrol | 207-889-6 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
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AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Other
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
ChEMBL / DailyMed
CARVACROL
ChEMBL Phase
2
Adverse Events
0
Bioactivity
6
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA
1 records
ADI: No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Isopropyl-o-cresol?
Isopropyl-o-cresol appears on 5 regulatory/inventory lists including active_ingredient; Europe; Pesticides, IFRA Transparency, Europe, and 2 more. Source: EPA CPDat.
Is Isopropyl-o-cresol used in cosmetics?
Yes, Isopropyl-o-cresol is also indexed as a cosmetic ingredient under the name Carvacrol. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Isopropyl-o-cresol come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is Isopropyl-o-cresol used outside industrial chemicals?
Isopropyl-o-cresol also appears in cosmetics, pharmaceutical, food safety, cannabis databases.