Warning GHS07 NOAEL Data REACH Registered Cosmetic Ingredient

Carbonic acid sodium salt (1:2)

Also known as: Carbonic acid disodium salt, Bisodium carbonate, Disodium carbonate (Na2CO3), Soda, Soda ash (+15 more)

CAS 497-19-8

Carbonic acid sodium salt (1:2) (CAS 497-19-8) is a chemical substance with GHS signal word Warning; key hazard signal: H319. Key regulatory status: REACH registered, 55 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC.

View cosmetic safety profile for Sodium Bicarbonate →

SOURCE noael studies public

NOAEL studies

SOURCE chemical inventory jurisdictions

Regulatory lists

SOURCE eu clp annex vi

GHS signal

Warning

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 26 fields

Name

Carbonic acid sodium salt (1:2)

CAS Number

497-19-8

DTXSID

DTXSID1029621

Molecular Formula

CH2O3.2Na

InChI Key

CDBYLPFSWZWCQE-UHFFFAOYSA-L

Monoisotopic Mass

107.979932

Synonyms

Carbonic acid disodium saltBisodium carbonateDisodium carbonate (Na2CO3)SodaSoda ashSodium carbonateSodium carbonate (Na2(CO3))Sodium carbonate, anhydrousCalcined sodaDense AshDynamar 5251QLight Ash

GHS / CLP Classification

EU harmonized hazard classification, hazard statements, pictograms, and signal word.

SOURCE EU CLP Annex VI (ECHA) 1 classifications

Hazard Class	H-Statements	Pictograms	Signal
Eye Irrit. 2	H319	GHS07	Warning

ICSC Chemical Safety

International Chemical Safety Card hazard and exposure summary.

SOURCE ILO/WHO International Chemical Safety Cards 1 records

Field	Value
GHS Signal Word	WARNING
GHS Hazard Statements	Causes serious eye irritation
Short-term Effects	The substance is severely irritating to the eyes. The substance is mildly irritating to the skin and respiratory tract.
Long-term Effects	The substance may have effects on the respiratory tract. This may result in perforation of the nasal septum. Repeated or prolonged contact with skin may cause dermatitis.
Routes of Exposure	The substance can be absorbed into the body by inhalation of dust.

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 60 records

pH regulating agentChelating agent

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 55 records

List	Keyword	Source
inert_ingredient; Pesticides	EPA	CPCat
inert_ingredient; non_food_use; Pesticides	EPA	CPCat
Europe; Specialty occupational products	Danish Environmental Protection Agency	Danish EPA
-	Journal of Chemical Engineering & Process Technology	Published Articles
drinking_water; Europe; manufacturing; plastic_additive	Belgaqua	CPCat
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	California Department of Pesticide Regulation	State of California
active_ingredient; Europe; Pesticides	European Commission	CPCat
inert_ingredient; non_food_use; Pesticides	EPA	CPCat
active_ingredient; Europe; Pesticides	Commission of the European Communities	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
Europe; supplements	EU	CPCat
Europe; food_additive; supplements	EU	CPCat

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 37 of 37 studies

Value	Unit	Endpoint	Route	Species	Source
=10	mg/m3	DNEL local	inhalation	Human	ToxValDB_GESTIS_DNEL
45P3261C7T	UNII	FDA UNII substance identifier	-	-	openFDA substances
45P3261C7T	UNII	FDA UNII substance identifier	-	-	openFDA substances
45P3261C7T	UNII	FDA UNII substance identifier	-	-	openFDA substances
45P3261C7T	UNII	FDA UNII substance identifier	-	-	openFDA substances
2.3	mg/L	LC50	Inhalation	-	NTP_ICE_acute_inhalation
=2800	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
=4090	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
>5000	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
179	mg/kg bw/day	NOAEL	oral	rabbit	COSMOS_DB
-	%	Positive reaction	Dermal	Human	NTP_ICE_skin_irritation
43.5	%	Viability (240 minutes)	Dermal	-	NTP_ICE_skin_irritation
44.7	%	Viability (240 minutes)	Dermal	-	NTP_ICE_skin_irritation
60.7	%	Viability (240 minutes)	Dermal	-	NTP_ICE_skin_irritation
73.8	%	Viability (3 minutes)	Dermal	-	NTP_ICE_skin_irritation
77.4	%	Viability (3 minutes)	Dermal	-	NTP_ICE_skin_irritation
87.5	%	Viability (3 minutes)	Dermal	-	NTP_ICE_skin_irritation
90	%	Viability (3 minutes)	Dermal	-	NTP_ICE_skin_irritation
92.1	%	Viability (3 minutes)	Dermal	-	NTP_ICE_skin_irritation
93.3	%	Viability (3 minutes)	Dermal	-	NTP_ICE_skin_irritation
93.5	%	Viability (3 minutes)	Dermal	-	NTP_ICE_skin_irritation
100.1	%	Viability (3 minutes)	Dermal	-	NTP_ICE_skin_irritation
100.7	%	Viability (3 minutes)	Dermal	-	NTP_ICE_skin_irritation
103.8	%	Viability (3 minutes)	Dermal	-	NTP_ICE_skin_irritation
140	%	Viability (3 minutes)	Dermal	-	NTP_ICE_skin_irritation
32.1	%	Viability (60 minutes)	Dermal	-	NTP_ICE_skin_irritation
64	%	Viability (60 minutes)	Dermal	-	NTP_ICE_skin_irritation
65.2	%	Viability (60 minutes)	Dermal	-	NTP_ICE_skin_irritation
78.3	%	Viability (60 minutes)	Dermal	-	NTP_ICE_skin_irritation
79	%	Viability (60 minutes)	Dermal	-	NTP_ICE_skin_irritation
83	%	Viability (60 minutes)	Dermal	-	NTP_ICE_skin_irritation
84.1	%	Viability (60 minutes)	Dermal	-	NTP_ICE_skin_irritation
84.3	%	Viability (60 minutes)	Dermal	-	NTP_ICE_skin_irritation
86.1	%	Viability (60 minutes)	Dermal	-	NTP_ICE_skin_irritation
107.5	%	Viability (60 minutes)	Dermal	-	NTP_ICE_skin_irritation
108.3	%	Viability (60 minutes)	Dermal	-	NTP_ICE_skin_irritation
142.9	%	Viability (60 minutes)	Dermal	-	NTP_ICE_skin_irritation

Showing 37 of 37 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records

Status	Name	EC Number	Link
Registered	Sodium carbonate	207-838-8	ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

permitted

Max

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL SODIUM CARBONATE

ChEMBL Phase

Adverse Events

Bioactivity

View full pharmaceutical profile →

Food Safety Data

Same-CAS food additive, ADI, and GRAS records where available.

SOURCE EFSA / FDA GRAS 1 records

E500 — ADI: NOT LIMITED mg/kg bw

View full food safety profile →

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the GHS hazard classification for Carbonic acid sodium salt (1:2)?

Carbonic acid sodium salt (1:2) (CAS 497-19-8) is classified under EU CLP Annex VI as Eye Irrit. 2 with signal word Warning. Hazard statements: H319. Source: EU CLP Annex VI (ECHA).

What is the NOAEL for Carbonic acid sodium salt (1:2)?

Carbonic acid sodium salt (1:2) has 37 NOAEL studies in the database. The lowest reported value is 10 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.

What regulatory lists include Carbonic acid sodium salt (1:2)?

Carbonic acid sodium salt (1:2) appears on 18 regulatory/inventory lists including inert_ingredient; Pesticides, inert_ingredient; non_food_use; Pesticides, Europe; Specialty occupational products, and 15 more. Source: EPA CPDat.

Is Carbonic acid sodium salt (1:2) used in cosmetics?

Yes, Carbonic acid sodium salt (1:2) is also indexed as a cosmetic ingredient under the name Sodium Bicarbonate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Carbonic acid sodium salt (1:2) come from?

Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Is Carbonic acid sodium salt (1:2) used outside industrial chemicals?

Carbonic acid sodium salt (1:2) also appears in cosmetics, pharmaceutical, food safety, cannabis databases.