What is the NOAEL for 7,4'-Dihydroxyisoflavone?
7,4'-Dihydroxyisoflavone has 26 NOAEL studies in the database. The lowest reported value is 0 unitless. Source: NTP_ICE_endocrine.
NOAEL Data
Cosmetic Ingredient
7,4'-Dihydroxyisoflavone
Also known as: 4',7-Dihydroxyisoflavone, 4H-1-Benzopyran-4-one, 7-hydroxy-3-(4-hydroxyphenyl)-, 7-Hydroxy-3-(4-hydroxyphenyl)-4-benzopyrone, Isoflavone, 4',7-dihydroxy- (8CI), Daidzein (+5 more)
CAS 486-66-8
7,4'-Dihydroxyisoflavone (CAS 486-66-8) is a chemical substance. Key regulatory status: 2 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat.
SOURCE
noael studies public
NOAEL studies
26
SOURCE
chemical inventory jurisdictions
Regulatory lists
2
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
16 fields
Name
7,4'-Dihydroxyisoflavone
CAS Number
486-66-8
DTXSID
DTXSID9022310
Molecular Formula
C15H10O4
InChI Key
ZQSIJRDFPHDXIC-UHFFFAOYSA-N
Monoisotopic Mass
254.057909
Synonyms
4',7-Dihydroxyisoflavone4H-1-Benzopyran-4-one, 7-hydroxy-3-(4-hydroxyphenyl)-7-Hydroxy-3-(4-hydroxyphenyl)-4-benzopyroneIsoflavone, 4',7-dihydroxy- (8CI)Daidzein5-18-04-00089BRN 0231523EINECS 207-635-4UNII-6287WC5J2L4',7-Dihydroxy-Isoflavone
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
1 records
Softener and conditioner
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
2 records
| List | Keyword | Source |
|---|---|---|
| detected; MN Chemical Screening; surface_water | Minnesota Pollution Control Agency | State of Minnesota |
| Canada; pharmaceutical | DrugBank | DrugBank |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 26 of 26 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 1.27680398815463 | uM | AC50 | - | - | NTP_ICE_endocrine |
| 37.76 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| 100000 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| >400000 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| 0.218386728108613 | uM | ACC | - | - | NTP_ICE_endocrine |
| 15.4 | uL/min/10^6 cells | Clint | - | Human | NTP_ICE_adme_parameters |
| 31.8 | uL/min/10^6 cells | Clint | - | Rat | NTP_ICE_adme_parameters |
| 795 | nM | EC50 | - | - | NTP_ICE_endocrine |
| 6287WC5J2L | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 6287WC5J2L | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 6287WC5J2L | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 6287WC5J2L | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0.0315 | fraction | Fu | - | Rat | NTP_ICE_adme_parameters |
| 0.0553 | fraction | Fu | - | Human | NTP_ICE_adme_parameters |
| =1.25 | mg/day | LEL | injection | Mouse | ToxValDB_Uterotrophic_Hershberger_DB |
| =2.5 | mg/day | LEL | oral | Mouse | ToxValDB_Uterotrophic_Hershberger_DB |
| =6 | mg | LEL | oral | Mouse | ToxValDB_Uterotrophic_Hershberger_DB |
| 100 | nM | LEL | - | - | NTP_ICE_endocrine |
| =500 | mg/kg bw/day | LEL | oral | Rat | ToxValDB_Uterotrophic_Hershberger_DB |
| =600 | mg/kg bw/day | LEL | oral | Mouse | ToxValDB_Uterotrophic_Hershberger_DB |
| 1000 | nM | LEL | - | - | NTP_ICE_endocrine |
| 10000 | nM | LEL | - | - | NTP_ICE_endocrine |
| 600 | mg/kg bw/day | LOEL | Oral | Mouse | NTP_ICE_endocrine |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
| 0.44 | unitless | Model Score | - | - | NTP_ICE_endocrine |
| 151 | nM | PC50 | - | - | NTP_ICE_endocrine |
Showing 26 of 26 studies
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
active
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
DAIDZEIN
ChEMBL Phase
2
Adverse Events
0
Bioactivity
9
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
1 food-safety record found.
View full food safety profile →Frequently Asked Questions
What regulatory lists include 7,4'-Dihydroxyisoflavone?
7,4'-Dihydroxyisoflavone appears on 2 regulatory/inventory lists including detected; MN Chemical Screening; surface_water, Canada; pharmaceutical. Source: EPA CPDat.
Is 7,4'-Dihydroxyisoflavone used in cosmetics?
Yes, 7,4'-Dihydroxyisoflavone is also indexed as a cosmetic ingredient under the name Daidzein. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 7,4'-Dihydroxyisoflavone come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS. All data traces to primary regulatory sources and is updated from official government databases.
Is 7,4'-Dihydroxyisoflavone used outside industrial chemicals?
7,4'-Dihydroxyisoflavone also appears in cosmetics, pharmaceutical, food safety databases.