What is the NOAEL for Daphnetin?
Daphnetin has 4 NOAEL studies in the database. The lowest reported value is XC84571RD2 UNII. Source: openFDA substances.
NOAEL Data
Cosmetic Ingredient
Daphnetin
Also known as: 7,8-Dihydroxycoumarin, 2H-1-Benzopyran-2-one, 7,8-dihydroxy- (9CI), Coumarin, 7,8-dihydroxy-, 5-18-03-00211, BRN 0009372 (+5 more)
CAS 486-35-1
Daphnetin (CAS 486-35-1) is a chemical substance. Key regulatory status: 1 regulatory/inventory list, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat.
Cross-Vertical Regulatory Divergence
Daphnetin is prohibited in EU cosmetics but has active industrial GHS classifications (H315, H319).
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
4
SOURCE
chemical inventory jurisdictions
Regulatory lists
1
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
16 fields
Name
Daphnetin
CAS Number
486-35-1
DTXSID
DTXSID00197560
Molecular Formula
C9H6O4
InChI Key
ATEFPOUAMCWAQS-UHFFFAOYSA-N
Monoisotopic Mass
178.026609
Synonyms
7,8-Dihydroxycoumarin2H-1-Benzopyran-2-one, 7,8-dihydroxy- (9CI)Coumarin, 7,8-dihydroxy-5-18-03-00211BRN 00093727,8-Dihydroxy-2H-1-benzopyran-2-oneEINECS 207-632-8NSC 633563UNII-XC84571RD2Daphnetol
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
1 records
Softener and conditioner
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
1 records
| List | Keyword | Source |
|---|---|---|
| active_ingredient; Europe; Pesticides | Commission of the European Communities | CPCat |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 4 of 4 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| XC84571RD2 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| XC84571RD2 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| XC84571RD2 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| XC84571RD2 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
Showing 4 of 4 studies
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
prohibited
Max
-
Category
Antioxidant
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
DAPHNETIN
ChEMBL Phase
-1
Adverse Events
0
Bioactivity
6
Frequently Asked Questions
What regulatory lists include Daphnetin?
Daphnetin appears on 1 regulatory/inventory list including active_ingredient; Europe; Pesticides. Source: EPA CPDat.
Is Daphnetin used in cosmetics?
Yes, Daphnetin is also indexed as a cosmetic ingredient under the name Daphnetin. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Daphnetin come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Does Daphnetin have different safety status in cosmetics vs industrial chemicals?
Daphnetin is prohibited in EU cosmetics but has active industrial GHS classifications (H315, H319).
Is Daphnetin used outside industrial chemicals?
Daphnetin also appears in cosmetics, pharmaceutical databases.