What is the NOAEL for 7-Methoxy-8-(3-methyl-2-butenyl)-coumarin?
7-Methoxy-8-(3-methyl-2-butenyl)-coumarin has 5 NOAEL studies in the database. The lowest reported value is XH1TI1759C UNII. Source: openFDA substances.
NOAEL Data
Cosmetic Ingredient
7-Methoxy-8-(3-methyl-2-butenyl)-coumarin
Also known as: 2H-1-Benzopyran-2-one, 7-methoxy-8-(3-methyl-2-buten-1-yl)-, 2H-1-Benzopyran-2-one, 7-methoxy-8-(3-methyl-2-butenyl)-, Coumarin, 7-methoxy-8-(3-methyl-2-butenyl)-, 7-Methoxy-8-(3-methyl-2-buten-1-yl)-2H-1-benzopyran-2-one, 7-Methoxy-8-isopentenylcoumarin (+5 more)
CAS 484-12-8
7-Methoxy-8-(3-methyl-2-butenyl)-coumarin (CAS 484-12-8) is a chemical substance. Key regulatory status: cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat.
SOURCE
NOAEL studies
NOAEL studies
5
SOURCE
Chemical inventory jurisdictions
Regulatory lists
0
SOURCE
EU CLP Annex VI
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
16 fields
Name
7-Methoxy-8-(3-methyl-2-butenyl)-coumarin
CAS Number
484-12-8
DTXSID
DTXSID20197507
Molecular Formula
C15H16O3
InChI Key
MBRLOUHOWLUMFF-UHFFFAOYSA-N
Monoisotopic Mass
244.109944
Synonyms
2H-1-Benzopyran-2-one, 7-methoxy-8-(3-methyl-2-buten-1-yl)-2H-1-Benzopyran-2-one, 7-methoxy-8-(3-methyl-2-butenyl)-Coumarin, 7-methoxy-8-(3-methyl-2-butenyl)-7-Methoxy-8-(3-methyl-2-buten-1-yl)-2H-1-benzopyran-2-one7-Methoxy-8-isopentenylcoumarin7-Methoxy-8-(3-methyl-2-butenyl)coumarin8-(3-Methyl-2-butenyl)herniarinOstholeOstolNSC 31868
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
1 records
Softener and conditioner
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 5 of 5 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| XH1TI1759C | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| XH1TI1759C | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| XH1TI1759C | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| XH1TI1759C | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =2905 | mg/kg bw | LD50 | oral | Rat | NTP ICE acute oral |
Showing 5 of 5 studies
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Skin Conditioning
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
ChEMBL / DailyMed
OSTHOLE
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
6
Frequently Asked Questions
Is 7-Methoxy-8-(3-methyl-2-butenyl)-coumarin used in cosmetics?
Yes, 7-Methoxy-8-(3-methyl-2-butenyl)-coumarin is also indexed as a cosmetic ingredient under the name OSTHOLE. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 7-Methoxy-8-(3-methyl-2-butenyl)-coumarin come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Is 7-Methoxy-8-(3-methyl-2-butenyl)-coumarin used outside industrial chemicals?
7-Methoxy-8-(3-methyl-2-butenyl)-coumarin also appears in cosmetics, pharmaceutical databases.